PMID- 33105675
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201127
IS  - 2218-1989 (Print)
IS  - 2218-1989 (Electronic)
IS  - 2218-1989 (Linking)
VI  - 10
IP  - 11
DP  - 2020 Oct 22
TI  - Novel Biomarkers to Distinguish between Type 3c and Type 2 Diabetes Mellitus by 
      Untargeted Metabolomics.
LID - 10.3390/metabo10110423 [doi]
LID - 423
AB  - Pancreatogenic diabetes mellitus (T3cDM) is a highly frequent complication of 
      pancreatic disease, especially chronic pancreatitis, and it is often misdiagnosed 
      as type 2 diabetes mellitus (T2DM). A correct diagnosis allows the appropriate 
      treatment of these patients, improving their quality of life, and various 
      technologies have been employed over recent years to search for specific 
      biomarkers of each disease. The main aim of this metabolomic project was to find 
      differential metabolites between T3cDM and T2DM. Reverse-phase liquid 
      chromatography coupled to high-resolution mass spectrometry was performed in 
      serum samples from patients with T3cDM and T2DM. Multivariate Principal Component 
      and Partial Least Squares-Discriminant analyses were employed to evaluate 
      between-group variations. Univariate and multivariate analyses were used to 
      identify potential candidates and the area under the receiver-operating 
      characteristic (ROC) curve was calculated to evaluate their diagnostic value. A 
      panel of five differential metabolites obtained an area under the ROC curve of 
      0.946. In this study, we demonstrate the usefulness of untargeted metabolomics 
      for the differential diagnosis between T3cDM and T2DM and propose a panel of five 
      metabolites that appear altered in the comparison between patients with these 
      diseases.
FAU - Jimenez-Luna, Cristina
AU  - Jimenez-Luna C
AD  - Institute of Biopathology and Regenerative Medicine (IBIMER), Center of 
      Biomedical Research (CIBM), University of Granada, Granada 18012, Spain.
FAU - Martin-Blazquez, Ariadna
AU  - Martin-Blazquez A
AD  - Fundacion MEDINA, Centro de Excelencia para la Investigacion en Medicamentos 
      Innovadores en Andalucia, Granada 18012, Spain.
FAU - Dieguez-Castillo, Carmelo
AU  - Dieguez-Castillo C
AD  - Department of Gastroenterology, San Cecilio University Hospital, Granada 18012, 
      Spain.
FAU - Diaz, Caridad
AU  - Diaz C
AUID- ORCID: 0000-0003-1240-0143
AD  - Fundacion MEDINA, Centro de Excelencia para la Investigacion en Medicamentos 
      Innovadores en Andalucia, Granada 18012, Spain.
FAU - Martin-Ruiz, Jose Luis
AU  - Martin-Ruiz JL
AD  - Department of Gastroenterology, San Cecilio University Hospital, Granada 18012, 
      Spain.
FAU - Genilloud, Olga
AU  - Genilloud O
AUID- ORCID: 0000-0002-4202-1219
AD  - Fundacion MEDINA, Centro de Excelencia para la Investigacion en Medicamentos 
      Innovadores en Andalucia, Granada 18012, Spain.
FAU - Vicente, Francisca
AU  - Vicente F
AUID- ORCID: 0000-0003-3198-9205
AD  - Fundacion MEDINA, Centro de Excelencia para la Investigacion en Medicamentos 
      Innovadores en Andalucia, Granada 18012, Spain.
FAU - Del Palacio, Jose Perez
AU  - Del Palacio JP
AUID- ORCID: 0000-0001-8918-6873
AD  - Fundacion MEDINA, Centro de Excelencia para la Investigacion en Medicamentos 
      Innovadores en Andalucia, Granada 18012, Spain.
FAU - Prados, Jose
AU  - Prados J
AUID- ORCID: 0000-0003-4303-7746
AD  - Institute of Biopathology and Regenerative Medicine (IBIMER), Center of 
      Biomedical Research (CIBM), University of Granada, Granada 18012, Spain.
FAU - Caba, Octavio
AU  - Caba O
AUID- ORCID: 0000-0003-1802-1398
AD  - Institute of Biopathology and Regenerative Medicine (IBIMER), Center of 
      Biomedical Research (CIBM), University of Granada, Granada 18012, Spain.
LA  - eng
GR  - PIN-0474-2016, PC-0549-2017, and PC-0498-2017/Junta de Andalucia/
GR  - DTS17/00081/Instituto de Salud Carlos III/
PT  - Journal Article
DEP - 20201022
PL  - Switzerland
TA  - Metabolites
JT  - Metabolites
JID - 101578790
PMC - PMC7690399
OTO - NOTNLM
OT  - biomarker
OT  - chronic pancreatitis
OT  - diagnosis
OT  - metabolomics
OT  - pancreatogenic diabetes mellitus
OT  - type 2 diabetes mellitus
OT  - untargeted LC-HRMS
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/28 06:00
MHDA- 2020/10/28 06:01
PMCR- 2020/11/01
CRDT- 2020/10/27 01:01
PHST- 2020/09/22 00:00 [received]
PHST- 2020/10/16 00:00 [revised]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2020/10/27 01:01 [entrez]
PHST- 2020/10/28 06:00 [pubmed]
PHST- 2020/10/28 06:01 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - metabo10110423 [pii]
AID - metabolites-10-00423 [pii]
AID - 10.3390/metabo10110423 [doi]
PST - epublish
SO  - Metabolites. 2020 Oct 22;10(11):423. doi: 10.3390/metabo10110423.