PMID- 33106215
OWN - NLM
STAT- MEDLINE
DCOM- 20201106
LR  - 20220417
IS  - 2214-0190 (Electronic)
IS  - 0895-3988 (Linking)
VI  - 33
IP  - 9
DP  - 2020 Sep 20
TI  - Association between Mean Ocular Perfusion Pressure and Diabetic Retinopathy in a 
      Northeastern Chinese Population.
PG  - 701-707
LID - 10.3967/bes2020.091 [doi]
AB  - OBJECTIVE: To evaluate the association between diabetic retinopathy (DR) and mean 
      ocular perfusion pressure (MOPP) in patients with type 2 diabetes mellitus 
      (T2DM). METHODS: Patients from the Fushun Diabetic Retinopathy Cohort Study 
      (FS-DIRECT), a community-based prospective cohort study conducted in northeast 
      China, were included in this study. The presence and severity of DR were 
      determined by grading fundus photographs according to the Early Treatment 
      Diabetic Retinopathy Study (ETDRS) retinopathy scale. Systolic and diastolic 
      blood pressure (SBP and DBP) were recorded using an electronic sphygmomanometer. 
      Intraocular pressure (IOP) was measured using an iCare rebound tonometer. MOPP 
      was calculated using the formula MOPP = 2/3 [DBP + 1/3 (SBP - DBP)] - IOP. 
      RESULTS: In total, 1,857 patients who had gradable fundus photography and MOPP 
      data were enrolled in this study. Male patients had a higher MOPP than female 
      patients (52.25 +/- 8.75 vs. 50.96 +/- 8.74 mmHg, P = 0.002). Overall, both male and 
      female patients with any type of DR, non-proliferative DR (NPDR), or 
      non-sight-threatening DR (non-STDR) had significantly higher MOPP relative to 
      patients without DR. Increased MOPP (per 1 mmHg) was in turn associated with the 
      presence of any type of DR [odds ratio ( OR) = 1.03, 95% confidence interval ( 
      CI) : 1.02-1.04], NPDR ( OR= 1.03 95% CI: 1.02-1.04), and non-STDR ( OR= 1.03, 
      95% CI: 1.01-1.04) after adjusting for confounders. Increased MOPP (per 1 mmHg) 
      was also associated with an increased likelihood of macular edema ( OR= 1.02 , 
      95% CI: 1.01-1.04). CONCLUSIONS: The results suggest that increased MOPP was 
      associated with DR and macular edema in northeastern Chinese patients with T2DM.
CI  - Copyright (c) 2020 The Editorial Board of Biomedical and Environmental Sciences. 
      Published by China CDC. All rights reserved.
FAU - Zhai, Gang
AU  - Zhai G
AD  - Fushun Eye Hospital, Fushun 113006, Liaoning, China.
FAU - Lin, Zhong
AU  - Lin Z
AD  - School of Ophthalmology & Optometry, Wenzhou Medical University, Eye Hospital of 
      Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
FAU - Wang, Feng Hua
AU  - Wang FH
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; 
      Beijing Ophthalmology & Visual Science Key Lab, Beijing 100730, China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Fushun Eye Hospital, Fushun 113006, Liaoning, China.
FAU - Li, Dong
AU  - Li D
AD  - Fushun Eye Hospital, Fushun 113006, Liaoning, China.
FAU - Wen, Liang
AU  - Wen L
AD  - Fushun Eye Hospital, Fushun 113006, Liaoning, China.
FAU - Ding, Xiao Xia
AU  - Ding XX
AD  - Fushun Eye Hospital, Fushun 113006, Liaoning, China.
FAU - Jiang, Jing
AU  - Jiang J
AD  - Fushun Eye Hospital, Fushun 113006, Liaoning, China.
FAU - Feng, Ke Mi
AU  - Feng KM
AD  - School of Ophthalmology & Optometry, Wenzhou Medical University, Eye Hospital of 
      Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
FAU - Liang, Yuan Bo
AU  - Liang YB
AD  - School of Ophthalmology & Optometry, Wenzhou Medical University, Eye Hospital of 
      Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
FAU - Xie, Cong
AU  - Xie C
AD  - Fushun Eye Hospital, Fushun 113006, Liaoning, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Biomed Environ Sci
JT  - Biomedical and environmental sciences : BES
JID - 8909524
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Retinopathy/*epidemiology/physiopathology
MH  - Female
MH  - Humans
MH  - Intraocular Pressure/*physiology
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - Diastolic blood pressure
OT  - Ocular perfusion pressure
OT  - Systolic blood pressure
EDAT- 2020/10/28 06:00
MHDA- 2020/11/11 06:00
CRDT- 2020/10/27 05:40
PHST- 2019/10/28 00:00 [received]
PHST- 2020/01/16 00:00 [accepted]
PHST- 2020/10/27 05:40 [entrez]
PHST- 2020/10/28 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
AID - 10.3967/bes2020.091 [doi]
PST - ppublish
SO  - Biomed Environ Sci. 2020 Sep 20;33(9):701-707. doi: 10.3967/bes2020.091.