PMID- 33106846
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20210628
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Print)
IS  - 1462-0324 (Linking)
VI  - 60
IP  - 4
DP  - 2021 Apr 6
TI  - Elevated serum level of hepatocyte growth factor predicts development of new 
      syndesmophytes in men with ankylosing spondylitis.
PG  - 1804-1813
LID - 10.1093/rheumatology/keaa460 [doi]
AB  - OBJECTIVES: To study baseline serum hepatocyte growth factor (s-HGF) as a 
      predictor of spinal radiographic progression overall and by sex and to analyse 
      factors correlated to changes in s-HGF in patients with AS. METHODS: At baseline 
      and the 5-year follow-up, s-HGF was analysed with ELISA. Spinal radiographs were 
      graded according to modified Stoke Ankylosing Spondylitis Spinal Score. 
      Radiographic progression was defined as >/=2 modified Stoke Ankylosing Spondylitis 
      Spinal Score units/5 years or development of >/=1 syndesmophyte. Logistic 
      regression analyses were used. RESULTS: Of 204 baseline participants, 163 (80%) 
      completed all examinations at the 5-year follow-up (54% men). Baseline s-HGF was 
      significantly higher in men who developed >/=1 syndesmophyte compared with 
      non-progressors, median (interquartile range) baseline s-HGF 1551 (1449-1898) vs 
      1436 (1200-1569) pg/ml, P = 0.003. The calculated optimal cut-off point for 
      baseline s-HGF >/=1520 pg/ml showed a sensitivity of 70%, a specificity of 69% and 
      univariate odds radio (95% CI) of 5.25 (1.69, 14.10) as predictor of development 
      of >/=1 new syndesmophyte in men. Baseline s-HGF >/=1520 pg/ml remained significantly 
      associated with development of >/=1 new syndesmophyte in men in an analysis 
      adjusted for the baseline variables age, smoking, presence of syndesmophytes and 
      CRP, odds radio 3.97 (1.36, 11.60). In women, no association with HGF and 
      radiographic progression was found. Changes in s-HGF were positively correlated 
      with changes in ESR and CRP. CONCLUSION: In this prospective cohort study 
      elevated s-HGF was shown to be associated with development of new syndesmophytes 
      in men with AS.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      British Society for Rheumatology.
FAU - Deminger, Anna
AU  - Deminger A
AD  - Department of Rheumatology and Inflammation Research, Institute of Medicine, 
      Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
AD  - Region Vastra Gotaland, Sahlgrenska University Hospital, Department of 
      Rheumatology, Gothenburg, Sweden.
FAU - Klingberg, Eva
AU  - Klingberg E
AD  - Department of Rheumatology and Inflammation Research, Institute of Medicine, 
      Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
AD  - Region Vastra Gotaland, Sahlgrenska University Hospital, Department of 
      Rheumatology, Gothenburg, Sweden.
FAU - Nurkkala, Merja
AU  - Nurkkala M
AD  - Department of Rheumatology and Inflammation Research, Institute of Medicine, 
      Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
FAU - Geijer, Mats
AU  - Geijer M
AD  - Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, 
      University of Gothenburg, Gothenburg, Sweden.
AD  - Region Vastra Gotaland, Sahlgrenska University Hospital, Department of Radiology, 
      Gothenburg, Sweden.
AD  - Department of Clinical Sciences, Lund University, Lund, Sweden.
FAU - Carlsten, Hans
AU  - Carlsten H
AD  - Department of Rheumatology and Inflammation Research, Institute of Medicine, 
      Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
AD  - Region Vastra Gotaland, Sahlgrenska University Hospital, Department of 
      Rheumatology, Gothenburg, Sweden.
FAU - Jacobsson, Lennart T H
AU  - Jacobsson LTH
AD  - Department of Rheumatology and Inflammation Research, Institute of Medicine, 
      Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
FAU - Forsblad-d'Elia, Helena
AU  - Forsblad-d'Elia H
AD  - Department of Rheumatology and Inflammation Research, Institute of Medicine, 
      Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
AD  - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - 0 (Biomarkers)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Sedimentation
MH  - C-Reactive Protein/analysis
MH  - Cervical Vertebrae/diagnostic imaging
MH  - Cohort Studies
MH  - *Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Hepatocyte Growth Factor/*blood
MH  - Humans
MH  - Lumbar Vertebrae/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Radiography
MH  - Spondylitis, Ankylosing/*diagnostic imaging
PMC - PMC8023989
OTO - NOTNLM
OT  - AS
OT  - hepatocyte growth factor
OT  - outcomes research
EDAT- 2020/10/28 06:00
MHDA- 2021/06/29 06:00
PMCR- 2020/10/27
CRDT- 2020/10/27 05:47
PHST- 2020/04/01 00:00 [received]
PHST- 2020/07/03 00:00 [revised]
PHST- 2020/10/28 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/10/27 05:47 [entrez]
PHST- 2020/10/27 00:00 [pmc-release]
AID - 5940679 [pii]
AID - keaa460 [pii]
AID - 10.1093/rheumatology/keaa460 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2021 Apr 6;60(4):1804-1813. doi: 
      10.1093/rheumatology/keaa460.