PMID- 33108861
OWN - NLM
STAT- MEDLINE
DCOM- 20210114
LR  - 20210114
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 34
IP  - 5
DP  - 2020 Sep-Oct,
TI  - Diagnostic value of the combined detection of CEA, NSE and IL-18 for lung cancer 
      and their relationship with apoptosis gene Bcl-2.
PG  - 1637-1646
LID - 10.23812/20-34-A [doi]
AB  - This study aims to investigate the value of the combined detection of 
      carcinoembryonic antigen (CEA), Neuron-specific enolase (NSE) and the level of 
      Interleukin-18 (IL-18) in the serum in the diagnosis of lung cancer. The 
      correlation between these parameters and the expression levels of B-cell 
      lymphoma-2 (Bcl-2) protein were also studied. Eighty patients with lung cancer 
      were included in the lung cancer group. These patients underwent surgery in the 
      Department of Oncology of Huai'an Second People's Hospital between February 2016 
      and February 2018. During the same period, another 80 patients with benign lung 
      lesions were registered in the benign lesion group and 80 healthy people were 
      enrolled in the control group. Enzyme-linked immunosorbent assay (ELISA) was used 
      to detect the expression levels of CEA, NSE and IL-18. The diagnostic critical 
      value of these factors was used as positive indicator. When CEA, NSE and IL-18 
      levels were positive at the same time, the combined detection was considered to 
      be positive. WB was used to detect Bcl-2 expression level. We also analyzed the 
      possible correlation between CEA, NSE, IL-18 levels and the Bcl-2 expression 
      levels. The CEA, NSE and IL-18 expression levels in the serum of the lung cancer 
      group were significantly higher than those in the benign lesion and the control 
      groups (p<0.05). The area under ROC curve for CEA, NSE and IL-18 respectively was 
      0.770 (0.697-0.843), 0.829 (0.767-0.890), 0.721 (0.642-0.800) (p<0.001). IL-18 
      level was negatively correlated with the level of Bcl-2 mRNA in the tissue 
      (r=-0.380, p<0.001). In conclusion, CEA, NSE and IL-18 have a good auxiliary 
      diagnostic value in patients with lung cancer. The combined detection could 
      improve the sensitivity and specificity of lung can notcer diagnosis. There was a 
      negative correlation between IL-18 and Bcl-2 levels which suggested a potential 
      inhibitory role of IL-18 on the lung cancer cells apoptosis pathway.
CI  - Copyright 2020 Biolife Sas. www.biolifesas.org.
FAU - Gu, R H
AU  - Gu RH
AD  - Department of Oncology, Huai'an Second People's Hospital, The Affiliated Huai'an 
      Hospital of Xuzhou Medical University, Huai'an, P.R. China.
FAU - Tan, B
AU  - Tan B
AD  - Department of Respiratory Medicine, Lianshui People's Hospital, Lianshui, P.R.
FAU - Ma, J
AU  - Ma J
AD  - Department of Oncology, Huai'an TCM Hospital Affiliated to Nanjing University of 
      Chinese Medicine, Jiangsu Huai'an, China.
FAU - Shen, W Y
AU  - Shen WY
AD  - Department of Respiratory Medicine, Lianshui People's Hospital, Lianshui, P.R. 
      China.
FAU - Zuo, Y S
AU  - Zuo YS
AD  - Department of Respiratory Medicine, Lianshui People's Hospital, Lianshui, P.R. 
      China.
FAU - Shi, L
AU  - Shi L
AD  - Department of Oncology, Huaian Hospital, Huaian, P.R. China.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Carcinoembryonic Antigen)
RN  - 0 (Interleukin-18)
RN  - 0 (Keratin-19)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Antigens, Neoplasm
MH  - Apoptosis
MH  - Biomarkers, Tumor/genetics
MH  - Carcinoembryonic Antigen
MH  - Humans
MH  - Interleukin-18
MH  - Keratin-19
MH  - *Lung Neoplasms/diagnosis
MH  - Phosphopyruvate Hydratase
MH  - Proto-Oncogene Proteins c-bcl-2
OTO - NOTNLM
OT  - Bcl-2
OT  - CEA
OT  - IL-18
OT  - NSE
EDAT- 2020/10/29 06:00
MHDA- 2021/01/15 06:00
CRDT- 2020/10/28 04:39
PHST- 2020/10/28 04:39 [entrez]
PHST- 2020/10/29 06:00 [pubmed]
PHST- 2021/01/15 06:00 [medline]
AID - 6 [pii]
AID - 10.23812/20-34-A [doi]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2020 Sep-Oct,;34(5):1637-1646. doi: 
      10.23812/20-34-A.