PMID- 3310957
OWN - NLM
STAT- MEDLINE
DCOM- 19871119
LR  - 20151119
IS  - 0003-9985 (Print)
IS  - 0003-9985 (Linking)
VI  - 111
IP  - 11
DP  - 1987 Nov
TI  - Major histocompatibility antigen expression in the liver in acquired 
      immunodeficiency syndrome.
PG  - 1045-9
AB  - Human leukocyte antigen (HLA) class I molecules are normally detected on most 
      nucleated cells, but not on hepatocytes, while the expression of HLA class II 
      antigens is mainly restricted to certain cell types of the immune system. This 
      normal distribution pattern may be altered in human liver in a variety of 
      disorders, particularly in infectious and immune diseases. In view of multiple 
      infections and severe immune alterations in acquired immunodeficiency syndrome 
      (AIDS), we studied the expression of HLA class I and class II antigens in liver 
      obtained at autopsy from ten patients with AIDS and eight control patients, using 
      a panel of monoclonal antibodies and the indirect immunofluorescence method. In 
      spite of viral bacterial, and fungal infections, HLA class I antigens were 
      detected on hepatocytes in only two patients with AIDS. Human leukocyte antigen 
      class II antigens were found unexpectedly on bile duct epithelium in five of ten 
      patients with AIDS and in one of eight control patients. The aberrant HLA class 
      II antigen expression on bile ducts does not appear to be linked to bile duct 
      damage or infection with cytomegalovirus or other agents, but may be related to 
      immune alterations in patients with AIDS.
FAU - Sieratzki, J
AU  - Sieratzki J
AD  - Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029.
FAU - Thung, S N
AU  - Thung SN
FAU - Gerber, M A
AU  - Gerber MA
FAU - Ferrone, S
AU  - Ferrone S
FAU - Schaffner, F
AU  - Schaffner F
LA  - eng
GR  - AI 21384/AI/NIAID NIH HHS/United States
GR  - DK 30854/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arch Pathol Lab Med
JT  - Archives of pathology & laboratory medicine
JID - 7607091
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*immunology/pathology
MH  - Adult
MH  - Antibodies, Monoclonal
MH  - Bile Ducts/immunology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - HLA Antigens/*analysis
MH  - Homosexuality
MH  - Humans
MH  - Liver/*immunology/pathology
MH  - Male
MH  - Middle Aged
EDAT- 1987/11/01 00:00
MHDA- 1987/11/01 00:01
CRDT- 1987/11/01 00:00
PHST- 1987/11/01 00:00 [pubmed]
PHST- 1987/11/01 00:01 [medline]
PHST- 1987/11/01 00:00 [entrez]
PST - ppublish
SO  - Arch Pathol Lab Med. 1987 Nov;111(11):1045-9.