PMID- 33109639
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 10
IP  - 10
DP  - 2020 Oct 26
TI  - Higher incidence of adverse events in isolated patients compared with 
      non-isolated patients: a cohort study.
PG  - e035238
LID - 10.1136/bmjopen-2019-035238 [doi]
LID - e035238
AB  - OBJECTIVE: To determine whether isolated patients admitted to hospital have a 
      higher incidence of adverse events (AEs), to identify their nature, impact and 
      preventability. DESIGN: Prospective cohort study with isolated and non-isolated 
      patients. SETTING: One public university hospital in the Valencian Community 
      (southeast Spain). PARTICIPANTS: We consecutively collected 400 patients, 200 
      isolated and 200 non-isolated, age >/=18 years old, to match according to date of 
      entry, admission department, sex, age (+/-5 years) and disease severity from April 
      2017 to October 2018. EXCLUSION CRITERIA: patients age <18 years old and/or 
      reverse isolation patients. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary 
      outcome as the AE, defined according to the National Study of Adverse Effects 
      linked to Hospitalisation (Estudio Nacional Sobre los Efectos Adversos) criteria. 
      Cumulative incidence rates and AE incidence density rates were calculated. 
      RESULTS: The incidence of isolated patients with AEs 16.5% (95% CI 11.4% to 
      21.6%) compared with 9.5% (95% CI 5.4% to 13.6%) in non-isolated (p<0.03). The 
      incidence density of patients with AEs among isolated patients was 11.8 per 
      1000 days/patient (95% CI 7.8 to 15.9) compared with 4.3 per 1000 days/patient 
      (95% CI 2.4 to 6.3) among non-isolated patients (p<0.001). The incidence of AEs 
      among isolated patients was 18.5% compared with 11% for non-isolated patients 
      (p<0.09). Among the 37 AEs detected in 33 isolated patients, and the 22 AEs 
      detected in 19 non-isolated patients, most corresponded to healthcare-associated 
      infections (HAIs) for both isolated and non-isolated patients (48.6% vs 45.4%). 
      There were significant differences with respect to the preventability of AEs, 
      (67.6% among isolated patients compared with 52.6% among non-isolated patients). 
      CONCLUSIONS: AEs were significantly higher in isolated patients compared with 
      non-isolated patients, more than half being preventable and with HAIs as the 
      primary cause. It is essential to improve training and the safety culture of 
      healthcare professionals relating to the care provided to this type of patient.
CI  - (c) Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Jimenez-Pericas, Fatima
AU  - Jimenez-Pericas F
AUID- ORCID: 0000-0001-7393-8567
AD  - Department of Preventive Medicine and Public Health, Hospital Universitari San 
      Juan de Alicante, Sant Joan d'Alacant, Spain jimper75@hotmail.com.
FAU - Gea Velazquez de Castro, Maria Teresa
AU  - Gea Velazquez de Castro MT
AD  - Department of Preventive Medicine and Public Health, Hospital Universitari San 
      Juan de Alicante, Sant Joan d'Alacant, Spain.
FAU - Pastor-Valero, Maria
AU  - Pastor-Valero M
AD  - Department of Public Health, History of Science and Gynaecology, Universidad 
      Miguel Hernandez, Elche, Spain.
FAU - Aibar Remon, Carlos
AU  - Aibar Remon C
AD  - Preventive Medicine and Public Health, Hospital Clinico Universitario Lozano 
      Blesa, Zaragoza, Spain.
AD  - Instituto de Investigacion Sanitaria Aragon, Zaragoza, Spain.
FAU - Miralles, Juan Jose
AU  - Miralles JJ
AD  - Department of Public Health, History of Science and Gynaecology, Universidad 
      Miguel Hernandez, Elche, Spain.
FAU - Meyer Garcia, Maria Del Carmen
AU  - Meyer Garcia MDC
AD  - Department of Preventive Medicine and Public Health, Hospital Politecnico y 
      Universitario La Fe, Valencia, Spain.
FAU - Aranaz Andres, Jesus Maria
AU  - Aranaz Andres JM
AD  - Preventive Medicine and Public Health, Hospital Universitario Ramon y Cajal, 
      Madrid, Spain.
AD  - Instituto Ramon y Cajal de Investigacion Sanitaria, Madrid, Comunidad de Madrid, 
      Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201026
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
EIN - BMJ Open. 2020 Dec 2;10(12):e035238corr1. PMID: 33268436
MH  - Adolescent
MH  - Cohort Studies
MH  - Humans
MH  - Incidence
MH  - *Medical Errors
MH  - Prospective Studies
MH  - Spain/epidemiology
PMC - PMC7592267
OTO - NOTNLM
OT  - health & safety
OT  - preventive medicine
OT  - public health
OT  - quality in health care
OT  - risk management
COIS- Competing interests: None declared.
EDAT- 2020/10/29 06:00
MHDA- 2021/05/15 06:00
PMCR- 2020/10/26
CRDT- 2020/10/28 05:31
PHST- 2020/10/28 05:31 [entrez]
PHST- 2020/10/29 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/10/26 00:00 [pmc-release]
AID - bmjopen-2019-035238 [pii]
AID - 10.1136/bmjopen-2019-035238 [doi]
PST - epublish
SO  - BMJ Open. 2020 Oct 26;10(10):e035238. doi: 10.1136/bmjopen-2019-035238.