PMID- 33110438
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 17
DP  - 2020
TI  - Beneficial effects of walnut (Juglans regia L.) oil-derived polyunsaturated fatty 
      acid prevents a prooxidant status and hyperlipidemia in pregnant rats with 
      diabetes.
PG  - 92
LID - 10.1186/s12986-020-00514-3 [doi]
LID - 92
AB  - BACKGROUND: Gestational diabetes mellitus has a long-term effect on pregnant 
      women. Walnut (Juglans regia L.) oil-derived polyunsaturated fatty acid (PUFA) 
      possesses multifarious pharmacological activities. This study investigated the 
      beneficial effects of walnut oil-derived PUFA on glucose metabolism, pregnancy 
      outcomes, oxidative stress, and lipid metabolism in gestational diabetes 
      mellitus. METHODS: The GDM rat model was generated by intraperitoneal injection 
      of streptozotocin (40 mg/kg) on gestational day (GD) 6, GD7 and GD8. The 
      differences between groups were estimated using one-way ANOVA followed by the 
      Tukey's multiple comparison test for post-hoc analysis. RESULTS: The results 
      indicated that PUFA could mitigate GDM in pregnant diabetic rats, as embodied by 
      the decrease of fasting blood glucose and the increase of plasma insulin and 
      hepatic glycogen levels. Also, PUFA could suppress oxidative stress in pregnant 
      diabetic rats, as reflected by the decrease of malondialdehyde content, an 
      increase of superoxide dismutase, catalase and gutathione peroxidase activities. 
      PUFA could also mitigate the abnormal changes of lipid profiles in plasma and 
      hepatic tissue. Moreover, the relative mRNA expression of sterol regulatory 
      element-binding transcription factor-1, stearoyl-CoA desaturase-1, fatty acid 
      synthase, and acetyl-coenzyme A carboxylase, was suppressed by PUFA in pregnant 
      diabetic rats. CONCLUSIONS: These results suggested that PUFA supplementation 
      during pregnancy is beneficial in preventing diabetic complications in pregnant 
      rats.
CI  - (c) The Author(s) 2020.
FAU - Sun, Bingmei
AU  - Sun B
AD  - Department of Gynaecology and Obstetrics, Central Hospital of Linyi, No. 17 
      Health Road of Yishui County, Linyi City, 276400 China.
FAU - Yan, Hua
AU  - Yan H
AD  - Department of Gynaecology and Obstetrics, Central Hospital of Linyi, No. 17 
      Health Road of Yishui County, Linyi City, 276400 China.
FAU - Li, Chao
AU  - Li C
AD  - Department of Gynaecology and Obstetrics, Central Hospital of Linyi, No. 17 
      Health Road of Yishui County, Linyi City, 276400 China.
FAU - Yin, Linlin
AU  - Yin L
AD  - Department of Gynaecology and Obstetrics, Central Hospital of Linyi, No. 17 
      Health Road of Yishui County, Linyi City, 276400 China.
FAU - Li, Fei
AU  - Li F
AD  - Department of Gynaecology and Obstetrics, Central Hospital of Linyi, No. 17 
      Health Road of Yishui County, Linyi City, 276400 China.
FAU - Zhou, Lianxiang
AU  - Zhou L
AD  - Department of Gynaecology and Obstetrics, Central Hospital of Linyi, No. 17 
      Health Road of Yishui County, Linyi City, 276400 China.
FAU - Han, Xiuqing
AU  - Han X
AUID- ORCID: 0000-0001-9666-647X
AD  - Department of Gynaecology and Obstetrics, Central Hospital of Linyi, No. 17 
      Health Road of Yishui County, Linyi City, 276400 China.
LA  - eng
PT  - Journal Article
DEP - 20201023
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC7583188
OTO - NOTNLM
OT  - Dyslipidemia
OT  - Gestational diabetes
OT  - Oxidative stress
OT  - Walnut oil-derived PUFA
COIS- Competing interestsThe authors declare no conflict of interest.
EDAT- 2020/10/29 06:00
MHDA- 2020/10/29 06:01
PMCR- 2020/10/23
CRDT- 2020/10/28 05:40
PHST- 2020/03/30 00:00 [received]
PHST- 2020/10/08 00:00 [accepted]
PHST- 2020/10/28 05:40 [entrez]
PHST- 2020/10/29 06:00 [pubmed]
PHST- 2020/10/29 06:01 [medline]
PHST- 2020/10/23 00:00 [pmc-release]
AID - 514 [pii]
AID - 10.1186/s12986-020-00514-3 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2020 Oct 23;17:92. doi: 10.1186/s12986-020-00514-3. 
      eCollection 2020.