PMID- 33113135
OWN - NLM
STAT- MEDLINE
DCOM- 20210324
LR  - 20210324
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 2207
DP  - 2021
TI  - Differential Scanning Calorimetry (DSC) on Sartan/Cyclodextrin Delivery 
      Formulations.
PG  - 163-174
LID - 10.1007/978-1-0716-0920-0_13 [doi]
AB  - Differential scanning calorimetry (DSC) is a widely utilized method for the 
      interactions of drug molecules with drug delivery systems (DDSs). Herein is 
      described a protocol for studying the interactions and entrapment efficiency of 
      the prototype sartan losartan and the polydynamic, structurally similar 
      irbesartan inside the nontoxic 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD). The 
      thermal scan properties of both sartan molecules have been studied when 
      physically mixed or complexed with the cyclodextrin. The thermograms indeed 
      showed significant differences between the mixtures and complexes, establishing 
      DSC as a valuable method to characterize the state of the drugs in these 
      pharmaceutical formulations.
FAU - Naziris, Nikolaos
AU  - Naziris N
AD  - Section of Pharmaceutical Technology, Department of Pharmacy, School of Health 
      Sciences, National and Kapodistrian University of Athens, Panepistimioupolis, 
      Zografou, Greece. niknaz@pharm.uoa.gr.
FAU - Chountoulesi, Maria
AU  - Chountoulesi M
AD  - Section of Pharmaceutical Technology, Department of Pharmacy, School of Health 
      Sciences, National and Kapodistrian University of Athens, Panepistimioupolis, 
      Zografou, Greece.
FAU - Ntountaniotis, Dimitrios
AU  - Ntountaniotis D
AD  - Laboratory of Organic Chemistry, Department of Chemistry, National and 
      Kapodistrian University of Athens, Panepistimioupolis, Zografou, Greece.
FAU - Mavromoustakos, Thomas
AU  - Mavromoustakos T
AD  - Laboratory of Organic Chemistry, Department of Chemistry, National and 
      Kapodistrian University of Athens, Panepistimioupolis, Zografou, Greece.
FAU - Demetzos, Costas
AU  - Demetzos C
AD  - Section of Pharmaceutical Technology, Department of Pharmacy, School of Health 
      Sciences, National and Kapodistrian University of Athens, Panepistimioupolis, 
      Zografou, Greece. demetzos@pharm.uoa.gr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Cyclodextrins)
RN  - 0 (Drug Carriers)
RN  - J0E2756Z7N (Irbesartan)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Calorimetry, Differential Scanning
MH  - Cyclodextrins/*chemistry
MH  - Drug Carriers/*chemistry
MH  - Irbesartan/*chemistry
MH  - Losartan/*chemistry
OTO - NOTNLM
OT  - 2-Hydroxypropyl-beta-cyclodextrin
OT  - Complexation
OT  - Differential scanning calorimetry
OT  - Interactions
OT  - Irbesartan
OT  - Losartan
OT  - Lyophilization
OT  - Mixing
EDAT- 2020/10/29 06:00
MHDA- 2021/03/25 06:00
CRDT- 2020/10/28 17:19
PHST- 2020/10/28 17:19 [entrez]
PHST- 2020/10/29 06:00 [pubmed]
PHST- 2021/03/25 06:00 [medline]
AID - 10.1007/978-1-0716-0920-0_13 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2021;2207:163-174. doi: 10.1007/978-1-0716-0920-0_13.