PMID- 33114529
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201128
IS  - 2079-7737 (Print)
IS  - 2079-7737 (Electronic)
IS  - 2079-7737 (Linking)
VI  - 9
IP  - 11
DP  - 2020 Oct 26
TI  - Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and 
      Abnormal Glutamatergic Transmission.
LID - 10.3390/biology9110359 [doi]
LID - 359
AB  - Metformin, a first-line drug for type 2 diabetes mellitus (T2DM), has been found 
      to reduce depressive symptoms in patients with comorbid depression and other 
      diseases. However, it is largely unclear how metformin ameliorates 
      depressive-like behaviors. Here, we used lipopolysaccharide (LPS) to induce 
      depressive-like behaviors in mice and found that LPS-treated mice exhibited 
      increased immobility in the forced swimming test (FST) and tail suspension test 
      (TST), as well as increased glutamatergic transmission. Furthermore, metformin 
      administration in the LPS-treated mice ameliorated depressive-like behaviors and 
      elevated glutamatergic transmission. Our results suggest that metformin has 
      antidepressant effects and can correct abnormal glutamatergic transmission, 
      providing an insight into the underlying mechanism by which metformin acts 
      against depression.
FAU - Chen, Jiang
AU  - Chen J
AD  - Laboratory of Synaptic Development and Plasticity, Institute of Life Science, 
      Nanchang University, Nanchang 330031, China.
AD  - Department of Biological Science, School of Life Sciences, Nanchang University, 
      Nanchang 330031, China.
FAU - Zhou, Tian
AU  - Zhou T
AD  - School of Basic Medical Sciences, Nanchang University, Nanchang 330031, China.
FAU - Guo, A-Min
AU  - Guo AM
AD  - Laboratory of Synaptic Development and Plasticity, Institute of Life Science, 
      Nanchang University, Nanchang 330031, China.
AD  - Department of Biological Science, School of Life Sciences, Nanchang University, 
      Nanchang 330031, China.
FAU - Chen, Wen-Bing
AU  - Chen WB
AUID- ORCID: 0000-0002-3386-7212
AD  - Laboratory of Synaptic Development and Plasticity, Institute of Life Science, 
      Nanchang University, Nanchang 330031, China.
AD  - Department of Biological Science, School of Life Sciences, Nanchang University, 
      Nanchang 330031, China.
FAU - Lin, Dong
AU  - Lin D
AD  - Laboratory of Synaptic Development and Plasticity, Institute of Life Science, 
      Nanchang University, Nanchang 330031, China.
AD  - Department of Biological Science, School of Life Sciences, Nanchang University, 
      Nanchang 330031, China.
FAU - Liu, Zi-Yang
AU  - Liu ZY
AD  - Laboratory of Synaptic Development and Plasticity, Institute of Life Science, 
      Nanchang University, Nanchang 330031, China.
AD  - Department of Biological Science, School of Life Sciences, Nanchang University, 
      Nanchang 330031, China.
FAU - Fei, Er-Kang
AU  - Fei EK
AUID- ORCID: 0000-0002-3581-9521
AD  - Laboratory of Synaptic Development and Plasticity, Institute of Life Science, 
      Nanchang University, Nanchang 330031, China.
LA  - eng
GR  - 81460215, 31771142, 31860268/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20201026
PL  - Switzerland
TA  - Biology (Basel)
JT  - Biology
JID - 101587988
PMC - PMC7692296
OTO - NOTNLM
OT  - depression
OT  - lipopolysaccharide (LPS)
OT  - metformin
OT  - synaptic transmission
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/30 06:00
MHDA- 2020/10/30 06:01
PMCR- 2020/11/01
CRDT- 2020/10/29 01:03
PHST- 2020/08/19 00:00 [received]
PHST- 2020/10/22 00:00 [revised]
PHST- 2020/10/23 00:00 [accepted]
PHST- 2020/10/29 01:03 [entrez]
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2020/10/30 06:01 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - biology9110359 [pii]
AID - biology-09-00359 [pii]
AID - 10.3390/biology9110359 [doi]
PST - epublish
SO  - Biology (Basel). 2020 Oct 26;9(11):359. doi: 10.3390/biology9110359.