PMID- 33114551
OWN - NLM
STAT- MEDLINE
DCOM- 20210303
LR  - 20210303
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 21
DP  - 2020 Oct 26
TI  - Dendritic Cells: Critical Regulators of Allergic Asthma.
LID - 10.3390/ijms21217930 [doi]
LID - 7930
AB  - Allergic asthma is a chronic inflammatory disease of the airways characterized by 
      airway hyperresponsiveness (AHR), chronic airway inflammation, and excessive T 
      helper (Th) type 2 immune responses against harmless airborne allergens. 
      Dendritic cells (DCs) represent the most potent antigen-presenting cells of the 
      immune system that act as a bridge between innate and adaptive immunity. 
      Pertinent to allergic asthma, distinct DC subsets are known to play a central 
      role in initiating and maintaining allergen driven Th2 immune responses in the 
      airways. Nevertheless, seminal studies have demonstrated that DCs can also 
      restrain excessive asthmatic responses and thus contribute to the resolution of 
      allergic airway inflammation and the maintenance of pulmonary tolerance. Notably, 
      the transfer of tolerogenic DCs in vivo suppresses Th2 allergic responses and 
      protects or even reverses established allergic airway inflammation. Thus, the 
      identification of novel DC subsets that possess immunoregulatory properties and 
      can efficiently control aberrant asthmatic responses is critical for the 
      re-establishment of tolerance and the amelioration of the asthmatic disease 
      phenotype.
FAU - Morianos, Ioannis
AU  - Morianos I
AD  - Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research 
      Foundation of the Academy of Athens, 11525 Athens, Greece.
FAU - Semitekolou, Maria
AU  - Semitekolou M
AD  - Cellular Immunology Laboratory, Center for Basic Research, Biomedical Research 
      Foundation of the Academy of Athens, 11525 Athens, Greece.
LA  - eng
GR  - 1030/Hellenic Foundation for Research and Innovation/
PT  - Journal Article
PT  - Review
DEP - 20201026
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Asthma/*immunology
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*metabolism
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Th2 Cells/*metabolism
PMC - PMC7663753
OTO - NOTNLM
OT  - activin-A
OT  - allergic asthma
OT  - cytokines
OT  - dendritic cells
OT  - pulmonary tolerance
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/30 06:00
MHDA- 2021/03/04 06:00
PMCR- 2020/11/01
CRDT- 2020/10/29 01:03
PHST- 2020/09/06 00:00 [received]
PHST- 2020/10/15 00:00 [revised]
PHST- 2020/10/25 00:00 [accepted]
PHST- 2020/10/29 01:03 [entrez]
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2021/03/04 06:00 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - ijms21217930 [pii]
AID - ijms-21-07930 [pii]
AID - 10.3390/ijms21217930 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Oct 26;21(21):7930. doi: 10.3390/ijms21217930.