PMID- 33115307
OWN - NLM
STAT- MEDLINE
DCOM- 20220802
LR  - 20220802
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 132
IP  - 8
DP  - 2022 Aug
TI  - Computed tomographic parameters correlate with coagulation disorders in isolated 
      traumatic brain injury.
PG  - 835-842
LID - 10.1080/00207454.2020.1844199 [doi]
AB  - BACKGROUND AND OBJECTIVE: The imbalanced hemostatic equilibrium caused by brain 
      tissue or vessel damage underlies the pathophysiology of traumatic brain injury 
      (TBI)-induced coagulopathy, and cranial computed tomography (CT) is the gold 
      standard for evaluating brain injury. The present study aimed to explore the 
      correlation between quantitative cranial CT parameters and coagulopathy after 
      TBI. METHODS: We retrospectively collected the medical records of TBI patients 
      with extracranial abbreviated injury scale (AIS) scores <3 who were admitted to 
      our institution. The quantitative cranial CT parameters of patients with and 
      without coagulopathy were compared, and univariate correlation analysis between 
      CT parameters and coagulation subtest values and platelet counts was performed. 
      The predictors for each subtest of coagulation function were probed by 
      multivariate regression. RESULTS: TBI patients with coagulopathy had a larger 
      intracerebral haematoma/contusion (ICH/C) volume (p < 0.001), a higher incidence 
      of compressed basal cisterns (p = 0.015), a higher Graeb score (p < 0.001) and 
      subarachnoid haematoma (Fisher's scaling score) (p = 0.019) than those without 
      coagulopathy. IH/C volume was identified as an independent risk factor for 
      predicting coagulopathy. ICH/C volume showed a significantly positive correlation 
      with APTT (Pearson's correlation = 0.333, p < 0.001), while a significant 
      negative correlation with PLT (Pearson's correlation = - 0.312, p < 0.001). 
      CONCLUSION: ICH/C volume was a main quantitative cranial CT parameter for 
      predicting coagulopathy, suggesting that parenchymal brain damage and vessel 
      injury were closely associated with coagulopathy after TBI.
FAU - Cui, Wenxing
AU  - Cui W
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi Province, China.
FAU - Shi, Yingwu
AU  - Shi Y
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi Province, China.
FAU - Zhao, Baocheng
AU  - Zhao B
AD  - Central medical district of Chinese, PLA General Hospital, Beijing, China.
FAU - Luo, Jianing
AU  - Luo J
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi Province, China.
FAU - Zhu, Gang
AU  - Zhu G
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi Province, China.
FAU - Guo, Hao
AU  - Guo H
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi Province, China.
FAU - Wang, Bao
AU  - Wang B
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi Province, China.
FAU - Yang, Chen
AU  - Yang C
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi Province, China.
FAU - Li, Zhihong
AU  - Li Z
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi Province, China.
FAU - Wang, Liang
AU  - Wang L
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi Province, China.
FAU - Qu, Yan
AU  - Qu Y
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi Province, China.
FAU - Ge, Shunnan
AU  - Ge S
AD  - Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, 
      Xi'an, Shaanxi Province, China.
LA  - eng
PT  - Journal Article
DEP - 20201110
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
SB  - IM
MH  - *Blood Coagulation Disorders/complications/etiology
MH  - *Brain Injuries
MH  - *Brain Injuries, Traumatic/complications/diagnostic imaging
MH  - Hematoma
MH  - Humans
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Computed tomographic
OT  - coagulation disorders
OT  - intracerebral haematoma/contusion
OT  - traumatic brain injury
EDAT- 2020/10/30 06:00
MHDA- 2022/08/03 06:00
CRDT- 2020/10/29 05:28
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2022/08/03 06:00 [medline]
PHST- 2020/10/29 05:28 [entrez]
AID - 10.1080/00207454.2020.1844199 [doi]
PST - ppublish
SO  - Int J Neurosci. 2022 Aug;132(8):835-842. doi: 10.1080/00207454.2020.1844199. Epub 
      2020 Nov 10.