PMID- 33116476
OWN - NLM
STAT- MEDLINE
DCOM- 20210625
LR  - 20210625
IS  - 1178-2005 (Electronic)
IS  - 1176-9106 (Print)
IS  - 1176-9106 (Linking)
VI  - 15
DP  - 2020
TI  - Minimal Clinically Important Difference in Barthel Index Dyspnea in Patients with 
      COPD.
PG  - 2591-2599
LID - 10.2147/COPD.S266243 [doi]
AB  - BACKGROUND: The Barthel Index dyspnea (BId) is responsive to physiological 
      changes and pulmonary rehabilitation in patients with chronic obstructive 
      pulmonary disease (COPD). However, the minimum clinically important difference 
      (MCID) has not been established yet. AIM: To identify the MCID of BId in patients 
      with COPD stratified according to the presence of chronic respiratory failure 
      (CRF) or not. MATERIALS AND METHODS: Using the Medical Research Council (MRC) 
      score as an anchor, receiver operating characteristic curves and quantile 
      regression were retrospectively evaluated before and after pulmonary 
      rehabilitation in 2327 patients with COPD (1151 of them with CRF). RESULTS: The 
      median post-rehabilitation changes in BId for all patients were -10 
      (interquartile range = -17 to -3, p<0.001), correlating significantly with 
      changes in MRC (r = 0.57, 95% CI = 0.53 to 0.59, p<0.001). Comparing different 
      methods of assessment, the MCID ranged from -6.5 to -9 points for patients 
      without and -7.5 to -12 points for patients with CRF. CONCLUSION: The most 
      conservative estimate of the MCID is -9 points in patients with COPD, without and 
      -12 in those with CRF. This estimate may be useful in the clinical interpretation 
      of data, particularly in response to intervention studies.
CI  - (c) 2020 Vitacca et al.
FAU - Vitacca, Michele
AU  - Vitacca M
AUID- ORCID: 0000-0002-9389-7915
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation Unit of 
      the Institute of Lumezzane, Brescia, Italy.
FAU - Malovini, Alberto
AU  - Malovini A
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Laboratory of Informatics and Systems 
      Engineering for Clinical Research of the Institute of Pavia, Pavia, Italy.
FAU - Balbi, Bruno
AU  - Balbi B
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation Unit of 
      the Institute of Veruno, Novara, Italy.
FAU - Aliani, Maria
AU  - Aliani M
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation Unit of 
      the Institute of Cassano Delle Murge, Bari, Italy.
FAU - Cirio, Serena
AU  - Cirio S
AUID- ORCID: 0000-0002-9714-8970
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation Unit of 
      the Institute of Pavia, Pavia, Italy.
FAU - Spanevello, Antonio
AU  - Spanevello A
AUID- ORCID: 0000-0002-3595-9903
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation Unit of 
      the Institute of Tradate, Varese, Italy.
AD  - University of Insubria, MACRO, Varese, Italy.
FAU - Fracchia, Claudio
AU  - Fracchia C
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation Unit of 
      the Institute of Montescano, Pavia, Italy.
FAU - Maniscalco, Mauro
AU  - Maniscalco M
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation Unit of 
      the Institute of Telese, Benevento, Italy.
FAU - Corica, Giacomo
AU  - Corica G
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Health Directorate of the Institute 
      of Lumezzane, Brescia, Italy.
FAU - Ambrosino, Nicolino
AU  - Ambrosino N
AUID- ORCID: 0000-0002-5331-1393
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation Unit of 
      the Institute of Montescano, Pavia, Italy.
FAU - Paneroni, Mara
AU  - Paneroni M
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Respiratory Rehabilitation Unit of 
      the Institute of Lumezzane, Brescia, Italy.
LA  - eng
PT  - Journal Article
DEP - 20201021
PL  - New Zealand
TA  - Int J Chron Obstruct Pulmon Dis
JT  - International journal of chronic obstructive pulmonary disease
JID - 101273481
SB  - IM
MH  - Dyspnea/diagnosis/etiology
MH  - Humans
MH  - *Minimal Clinically Important Difference
MH  - *Pulmonary Disease, Chronic Obstructive/complications/diagnosis
MH  - ROC Curve
MH  - Retrospective Studies
PMC - PMC7585803
OTO - NOTNLM
OT  - activities of daily life
OT  - breathlessness
OT  - chronic respiratory failure
OT  - dyspnea
OT  - exercise training
OT  - health related quality of life
OT  - rehabilitation
COIS- All authors report no conflict to disclose.
EDAT- 2020/10/30 06:00
MHDA- 2021/06/29 06:00
PMCR- 2020/10/21
CRDT- 2020/10/29 05:48
PHST- 2020/06/05 00:00 [received]
PHST- 2020/09/07 00:00 [accepted]
PHST- 2020/10/29 05:48 [entrez]
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2020/10/21 00:00 [pmc-release]
AID - 266243 [pii]
AID - 10.2147/COPD.S266243 [doi]
PST - epublish
SO  - Int J Chron Obstruct Pulmon Dis. 2020 Oct 21;15:2591-2599. doi: 
      10.2147/COPD.S266243. eCollection 2020.