PMID- 33116704
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220417
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 13
DP  - 2020
TI  - Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 
      2 Diabetes Mellitus Among an Admixed Population of Mexico.
PG  - 3527-3534
LID - 10.2147/DMSO.S268329 [doi]
AB  - PURPOSE: This study aimed to analyze the association of the apolipoprotein E 
      (ApoE) polymorphisms with type 2 diabetes mellitus (T2DM) among the admixed 
      population of West Mexico. PATIENTS AND METHODS: ApoE genotypes were determined 
      in 168 T2DM patients and 449 non-diabetic control subjects from the general 
      admixed population of West Mexico. The non-diabetic subjects were stratified 
      according to body mass index (BMI) in normal weight (n=186), overweight (n=138), 
      and obesity (n=125). ApoE genotypes were assessed by using a TaqMan allelic 
      discrimination assay, insulin resistance (IR) by HOMA-IR, and biochemistry with a 
      dry chemistry assay. RESULTS: The rate of dyslipidemias and IR increased by BMI 
      category among the control subjects. The greater shift in the prevalence of 
      dyslipidemia was observed from normal weight (51.4%) to overweight (76.6%), 
      p<0.01. Normal weight or obese e4 allele carriers had a higher level of total 
      cholesterol and hypercholesterolemia than non-e4 carriers. Among the T2DM 
      patients, the e2 carriers had abnormal HOMA-IR value than the non-e2 carriers 
      (p=0.002). Comparatively, between the T2DM patients vs non-diabetics, the e2e3 
      genotype or e2 allele conferred a higher risk for T2DM (adjusted OR= 2.36, 95% CI 
      1.28-4.34, p=0.006 and adjusted OR=2.1, 95% Cl 1.20-3.79, p=0.009, respectively). 
      CONCLUSION: The ApoE e2 allele was associated with IR and the risk of T2DM in 
      subjects from the general admixed population of West Mexico.
CI  - (c) 2020 Gonzalez-Aldaco et al.
FAU - Gonzalez-Aldaco, Karina
AU  - Gonzalez-Aldaco K
AUID- ORCID: 0000-0001-5129-3307
AD  - Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray 
      Antonio Alcalde", Health Sciences Center, University of Guadalajara, Guadalajara, 
      Jalisco, Mexico.
FAU - Roman, Sonia
AU  - Roman S
AUID- ORCID: 0000-0001-7061-6634
AD  - Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray 
      Antonio Alcalde", Health Sciences Center, University of Guadalajara, Guadalajara, 
      Jalisco, Mexico.
FAU - Torres-Reyes, Luis A
AU  - Torres-Reyes LA
AUID- ORCID: 0000-0002-3060-9445
AD  - Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray 
      Antonio Alcalde", Health Sciences Center, University of Guadalajara, Guadalajara, 
      Jalisco, Mexico.
FAU - Panduro, Arturo
AU  - Panduro A
AUID- ORCID: 0000-0003-4784-748X
AD  - Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray 
      Antonio Alcalde", Health Sciences Center, University of Guadalajara, Guadalajara, 
      Jalisco, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20201006
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC7547770
OTO - NOTNLM
OT  - ApoE
OT  - HOMA-IR
OT  - dyslipidemia
OT  - hepatopathogenic diet
OT  - nutritional transition
OT  - obesity
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/10/30 06:00
MHDA- 2020/10/30 06:01
PMCR- 2020/10/06
CRDT- 2020/10/29 05:49
PHST- 2020/06/23 00:00 [received]
PHST- 2020/08/13 00:00 [accepted]
PHST- 2020/10/29 05:49 [entrez]
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2020/10/30 06:01 [medline]
PHST- 2020/10/06 00:00 [pmc-release]
AID - 268329 [pii]
AID - 10.2147/DMSO.S268329 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2020 Oct 6;13:3527-3534. doi: 10.2147/DMSO.S268329. 
      eCollection 2020.