PMID- 33118115 OWN - NLM STAT- MEDLINE DCOM- 20210916 LR - 20210916 IS - 1573-2584 (Electronic) IS - 0301-1623 (Print) IS - 0301-1623 (Linking) VI - 53 IP - 4 DP - 2021 Apr TI - The EPIC-26 domain scores after radical prostatectomy are associated with the personality trait of neuroticism. PG - 691-698 LID - 10.1007/s11255-020-02688-4 [doi] AB - PURPOSE: The personality trait of neuroticism represents vulnerability for mental distress to somatic health problems. There are few studies of neuroticism in prostate cancer patients. This study examines the levels of self-reported adverse effects (AEs) after robot-assisted radical prostatectomy (RALP) in Norwegian men with high or low levels of neuroticism. Neuroticism is also compared to relevant factors concerning their associations with various AEs. METHODS: Among 982 men who had RALP at Oslo University Hospital, Radiumhospitalet between 2005 and 2010, 79% responded to a mailed questionnaire in 2011. They rated AEs by completing the EPIC-26 questionnaire, and neuroticism on the Eysenck Personality Questionnaire (EPQ). Men with < 1 year's follow-up, treatment failure, and incomplete EPQ responses were omitted, leaving 524 men for analysis. The EPQ responses were dichotomized into low and high level of neuroticism. Stepwise multivariate linear regression analyses were used for examination of associations with the EPIC-26 domain scores. RESULTS: High neuroticism was reported by 20% (95% CI 17-23%) of the patients. On the EPIC-26 dimensions men with high neuroticism had significantly lower mean scores than men with low neuroticism. Most of these between-group differences were clinically significant. In multivariate regression analyses, high neuroticism contributed significantly to all EPIC-26 domains. CONCLUSION: Increased levels of AEs after RALP are significantly associated with high neuroticism. A short screening test should be added to the current EPIC-26 instrument to identify patients with high neuroticism. In these patients, pre-operative counseling should take into account their risk of increased AE experiences. FAU - Dahl, Alv A AU - Dahl AA AUID- ORCID: 0000-0002-6849-2756 AD - National Advisory Unit for Late Effects After Cancer Therapy, Oslo University Hospital, The Norwegian Radium Hospital, Nydalen, P.O. Box 4953, 0424, Oslo, Norway. a.a.dahl@medisin.uio.no. AD - Faculty of Medicine, University of Oslo, Oslo, Norway. a.a.dahl@medisin.uio.no. FAU - Fossa, Sophie D AU - Fossa SD AD - National Advisory Unit for Late Effects After Cancer Therapy, Oslo University Hospital, The Norwegian Radium Hospital, Nydalen, P.O. Box 4953, 0424, Oslo, Norway. AD - Faculty of Medicine, University of Oslo, Oslo, Norway. FAU - Brennhovd, Bjorn AU - Brennhovd B AD - Department of Urology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway. FAU - Axcrona, Karol AU - Axcrona K AD - Department of Urology, Akershus University Hospital, Lorenskog, Norway. LA - eng PT - Journal Article DEP - 20201028 PL - Netherlands TA - Int Urol Nephrol JT - International urology and nephrology JID - 0262521 SB - IM MH - Aged MH - Cross-Sectional Studies MH - Diagnostic Self Evaluation MH - Humans MH - Male MH - Middle Aged MH - *Neuroticism MH - Norway MH - Postoperative Complications/diagnosis/psychology MH - Prostatectomy/adverse effects/methods/*psychology MH - Psychological Tests PMC - PMC8032572 OTO - NOTNLM OT - Adverse effects OT - EPIC-26 OT - Neuroticism OT - Prostate cancer OT - Robot-assisted laparoscopic prostatectomy COIS- The authors declare that they have no competing interests. EDAT- 2020/10/30 06:00 MHDA- 2021/09/18 06:00 PMCR- 2020/10/28 CRDT- 2020/10/29 05:55 PHST- 2020/09/02 00:00 [received] PHST- 2020/10/21 00:00 [accepted] PHST- 2020/10/30 06:00 [pubmed] PHST- 2021/09/18 06:00 [medline] PHST- 2020/10/29 05:55 [entrez] PHST- 2020/10/28 00:00 [pmc-release] AID - 10.1007/s11255-020-02688-4 [pii] AID - 2688 [pii] AID - 10.1007/s11255-020-02688-4 [doi] PST - ppublish SO - Int Urol Nephrol. 2021 Apr;53(4):691-698. doi: 10.1007/s11255-020-02688-4. Epub 2020 Oct 28.