PMID- 33118540
OWN - NLM
STAT- MEDLINE
DCOM- 20211012
LR  - 20211012
IS  - 1842-1121 (Electronic)
IS  - 1841-8724 (Linking)
VI  - 29
IP  - 4
DP  - 2020 Oct 27
TI  - HLA Alleles and KIR Genes in Romanian Patients with Chronic Hepatitis C.
PG  - 595-601
LID - 10.15403/jgld-2546 [doi]
AB  - BACKGROUND AND AIMS: The role of natural killer (NK) cells in the defense against 
      hepatitis C virus (HCV) infection involve both innate and adaptive immunity. NK 
      cells express a large panel of inhibitory and activating receptors who bind human 
      leukocyte antigen (HLA) class I receptors. Killer cell immunoglobulin-like 
      receptors (KIRs) are the most polymorphic of these receptors being encoded by 
      genes distributed differently in unrelated individuals. The aim of this study was 
      to look at the immune response in chronic HCV patients by assessing NK-KIR genes 
      and their corresponding HLA ligands. METHODS: We genotyped 127 chronically 
      HCV-infected patients and 130 non-infected healthy individuals for both KIR genes 
      and their HLA ligands. The HLA-A, HLA-B, HLA-C genotypes were analyzed using 
      polymerase chain reaction high-resolution typing. RESULTS: KIR2DL3, KIR2DL5, 
      KIR2DS4 norm, KIR3DL3, KIR2DP1, KIR3DP1 genes were significantly increased in the 
      HCV group compared to healthy individual. Analysis of various HLA haplotypes 
      revealed different HLA alleles associated with increased susceptibility to HCV 
      infection. Thus, HLA A*23:01 was more frequent in the patients' group than in the 
      controls (p=0.030). At the same time HLA B*44:02 and C*04:02 were significantly 
      elevated in HCV-positive patients (p=0.008 and respectively p= 0.007). 
      CONCLUSIONS: These results suggest that the expression of KIR2DL3, KIR2DL5, 
      KIR2DS4 norm, KIR3DL3 genes and the association with HLA alleles such as HLA 
      A*23:01, B*44:02, C*04:02 may increase the patient susceptibility to chronic HCV 
      infection.
FAU - Ursu, Larisa
AU  - Ursu L
AD  - Centre for Immunogenetics and Virology, Fundeni Clinical Institute, Carol Davila 
      University of Medicine and Pharmacy, Bucharest, Romania. . 
      larissa.ursu@gmail.com.
FAU - Calenic, Bogdan
AU  - Calenic B
AD  - Department of Biochemistry, Faculty of Dental Medicine, Carol Davila University 
      of Medicine and Pharmacy, Bucharest, Romania. . drcalenic@gmail.com.
FAU - Diculescu, Mircea
AU  - Diculescu M
AD  - Gastroenterology and Hepatology Department, Fundeni Clinical Institute, Carol 
      Davila University of Medicine and Pharmacy, Bucharest, Romania. 
      mmdiculescu@yahoo.com.
FAU - Dima, Alina
AU  - Dima A
AD  - Rheumatology Department, Colentina Clinical Hospital, Bucharest, Romania. 
      alina_dima@outlook.com.
FAU - Constantinescu, Ileana
AU  - Constantinescu I
AD  - Centre for Immunogenetics and Virology, Fundeni Clinical Institute, Carol Davila 
      University of Medicine and Pharmacy, Bucharest, Romania. 
      ileana.constantinescu@imunogenetica.ro.
LA  - eng
PT  - Journal Article
DEP - 20201027
PL  - Romania
TA  - J Gastrointestin Liver Dis
JT  - Journal of gastrointestinal and liver diseases : JGLD
JID - 101272825
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genes, MHC Class I/*genetics
MH  - Hepatitis C, Chronic/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Receptors, KIR/*genetics
MH  - Romania
EDAT- 2020/10/30 06:00
MHDA- 2021/10/13 06:00
CRDT- 2020/10/29 08:40
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2021/10/13 06:00 [medline]
PHST- 2020/10/29 08:40 [entrez]
AID - 10.15403/jgld-2546 [doi]
PST - epublish
SO  - J Gastrointestin Liver Dis. 2020 Oct 27;29(4):595-601. doi: 10.15403/jgld-2546.