PMID- 33118740 OWN - NLM STAT- MEDLINE DCOM- 20210204 LR - 20210204 IS - 1678-9741 (Electronic) IS - 0102-7638 (Print) IS - 0102-7638 (Linking) VI - 35 IP - 5 DP - 2020 Oct 1 TI - Cardiac Shock Wave Therapy for Coronary Heart Disease: an Updated Meta-analysis. PG - 741-756 LID - 10.21470/1678-9741-2019-0276 [doi] AB - INTRODUCTION: The aim of this article is to study the efficacy and safety of cardiac shock wave therapy (CSWT) in the treatment of coronary heart disease (CAD). METHODS: A comprehensive search of electronic databases and a manual search of conference papers and abstracts were performed until September 30, 2018. The studies using RevMan 5.3 and STATA 14.0 softwares were reviewed, and meta-analyses were performed on 13 indicators, such as a six-min walking distance test (6MWT), New York Heart Association (NYHA) functional class, Seattle Angina Questionnaire (SAQ) score, angina class (Canadian Cardiology Society [CCS]), etc. RESULTS: A total of 26 articles were included. The total patient population was 855, of which 781 patients were treated with CSWT. Meta-analyses indicated that 6MWT (mean difference [MD] 75.64, 95% confidence interval [CI] 49.03, 102.25, P<0.00001) and NYHA (MD -0.70, 95% CI -0.92) in the CSWT group were comparable to those in the conventional revascularization group (MD -0.70, 95% CI -0.92, -0.49, P<0.00001). SAQ (MD 10.75, 95% CI 6.66, 14.83, P<0.00001), CCS (MD -0.99, 95% CI -1.13, -0.84, P<0.00001), nitrate dosage (MD -1.84, 95% CI -2.77, -1.12, P<0.00001), LVEF (MD 3.77, 95% CI 2.17, 5.37, P<0.00001), and SSS (MD -4.29, 95% CI -5.61, -2.96, P<0.00001), SRS (MD -2.90, 95% CI -4.85, -0.95, P=0.004), and the exercise test (standard mean difference 0.57, 95% CI 0.12, 1.02, P=0.01) all showed significant differences. CONCLUSION: CSWT may offer beneficial effects to patients with CAD, but more large-scale clinical studies are needed to further verify its therapeutic effect. FAU - Yang, Hai-Tao AU - Yang HT AD - Xinjiang Medical University First Affiliated Hospital Department of Cardiology Urumchi People's Republic of China Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumchi, People's Republic of China. FAU - Xie, Xiang AU - Xie X AD - Xinjiang Medical University First Affiliated Hospital Department of Cardiology Urumchi People's Republic of China Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumchi, People's Republic of China. FAU - Hou, Xian-Geng AU - Hou XG AD - Changji Hui Autonomous Prefecture People's Hospital Department of Cardiology People's Republic of China Department of Cardiology, Changji Hui Autonomous Prefecture People's Hospital, People's Republic of China. FAU - Xiu, Wen-Juan AU - Xiu WJ AD - Xinjiang Medical University First Affiliated Hospital Department of Cardiology Urumchi People's Republic of China Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumchi, People's Republic of China. FAU - Wu, Ting-Ting AU - Wu TT AD - Xinjiang Medical University First Affiliated Hospital Department of Cardiology Urumchi People's Republic of China Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumchi, People's Republic of China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't DEP - 20201001 PL - Brazil TA - Braz J Cardiovasc Surg JT - Brazilian journal of cardiovascular surgery JID - 101677045 RN - 0 (Angiotensin Receptor Antagonists) RN - 0 (Angiotensin-Converting Enzyme Inhibitors) SB - IM MH - Angiotensin Receptor Antagonists MH - Angiotensin-Converting Enzyme Inhibitors MH - Canada MH - Cohort Studies MH - *Coronary Disease/therapy MH - *Extracorporeal Shockwave Therapy MH - High-Energy Shock Waves MH - Humans MH - Male MH - Percutaneous Coronary Intervention MH - Treatment Outcome PMC - PMC7598952 OTO - NOTNLM OT - Confidence Intervals OT - Coronary Disease OT - Exercise Test OT - Extracorporeal Shockwave Therapy OT - Heart OT - Walking COIS- No conflict of interest. EDAT- 2020/10/30 06:00 MHDA- 2021/02/05 06:00 PMCR- 2020/09/01 CRDT- 2020/10/29 10:58 PHST- 2020/10/30 06:00 [pubmed] PHST- 2021/02/05 06:00 [medline] PHST- 2020/10/29 10:58 [entrez] PHST- 2020/09/01 00:00 [pmc-release] AID - 10.21470/1678-9741-2019-0276 [doi] PST - epublish SO - Braz J Cardiovasc Surg. 2020 Oct 1;35(5):741-756. doi: 10.21470/1678-9741-2019-0276.