PMID- 33118903
OWN - NLM
STAT- MEDLINE
DCOM- 20220210
LR  - 20220210
IS  - 2040-1752 (Electronic)
IS  - 2040-1744 (Linking)
VI  - 12
IP  - 5
DP  - 2021 Oct
TI  - Influence of prenatal stress on metabolic abnormalities induced by postnatal 
      intake of a high-fat diet in BALB/c mice.
PG  - 721-730
LID - 10.1017/S2040174420000987 [doi]
AB  - Prenatal insults during fetal development result in increased likelihood of 
      developing chronic disease. Obesity, the biggest risk factor for the development 
      of metabolic disease, is affected by several genetic and environmental factors. 
      High-fat diet (HFD) consumption is usually linked with the development of 
      obesity. The main goal of this study was to analyze the impact of the exposure to 
      a HFD in prenatally stressed animals. For this purpose, we subjected pregnant 
      BALB/c mice to restraint stress for 2 h a day between gestational day (GD) 14 and 
      GD 21. Prenatally stressed and control offspring of both sexes were postnatally 
      exposed to a HFD for 24 weeks. We found that prenatal stress (PS) per se produced 
      disturbances in males such as increased total blood cholesterol and 
      triglycerides, with a decrease in mRNA expression of sirtuin-1. When these 
      animals were fed a HFD, we observed a rise in glucose and insulin levels and an 
      increase in visceral adipose tissue gene expression of leptin, resistin, and 
      interleukin-1 beta. Although females proved to be more resilient to PS 
      consequences, when they were fed a HFD, they showed significant metabolic 
      impairment. In addition to the changes observed in males, females also presented 
      an increase in body weight and adiposity and a rise in cholesterol levels.
FAU - Juarez, Yamila Raquel
AU  - Juarez YR
AD  - Instituto de Investigaciones Biomedicas, Consejo Nacional de Investigaciones 
      Cientificas y Tecnicas (CONICET) - Pontificia Universidad Catolica Argentina, 
      Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina.
FAU - Quiroga, Sofia
AU  - Quiroga S
AD  - Instituto de Investigaciones Biomedicas, Consejo Nacional de Investigaciones 
      Cientificas y Tecnicas (CONICET) - Pontificia Universidad Catolica Argentina, 
      Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina.
FAU - Prochnik, Andres
AU  - Prochnik A
AD  - Instituto de Investigaciones Biomedicas, Consejo Nacional de Investigaciones 
      Cientificas y Tecnicas (CONICET) - Pontificia Universidad Catolica Argentina, 
      Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina.
FAU - Wald, Miriam
AU  - Wald M
AD  - Instituto de Investigaciones Biomedicas, Consejo Nacional de Investigaciones 
      Cientificas y Tecnicas (CONICET) - Pontificia Universidad Catolica Argentina, 
      Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina.
FAU - Tellechea, Mariana Lorena
AU  - Tellechea ML
AD  - Centro de Investigaciones Endocrinologicas "Dr. Cesar Bergada" (CEDIE), CONICET - 
      FEI - Division de Endocrinologia, Hospital de Ninos R. Gutierrez, Gallo 1330, 
      C1425EFDBuenos Aires, Argentina.
FAU - Genaro, Ana Maria
AU  - Genaro AM
AD  - Instituto de Investigaciones Biomedicas, Consejo Nacional de Investigaciones 
      Cientificas y Tecnicas (CONICET) - Pontificia Universidad Catolica Argentina, 
      Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina.
AD  - Departamento de Farmacologia, Facultad de Medicina, Universidad de Buenos Aires. 
      Paraguay 2151 Piso 15, Buenos AiresC1121ABG, Argentina.
FAU - Burgueno, Adriana Laura
AU  - Burgueno AL
AUID- ORCID: 0000-0001-7584-7044
AD  - Instituto de Investigaciones Biomedicas, Consejo Nacional de Investigaciones 
      Cientificas y Tecnicas (CONICET) - Pontificia Universidad Catolica Argentina, 
      Alicia Moreau de Justo 1600, Buenos AiresC1107AFF, Argentina.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201029
PL  - England
TA  - J Dev Orig Health Dis
JT  - Journal of developmental origins of health and disease
JID - 101517692
SB  - IM
MH  - Animals
MH  - Diet, High-Fat/*adverse effects/methods
MH  - Disease Models, Animal
MH  - Female
MH  - Metabolic Diseases/diet therapy/*etiology
MH  - Mice
MH  - Mice, Inbred BALB C/abnormalities/*metabolism
MH  - Pregnancy
OTO - NOTNLM
OT  - Prenatal stress
OT  - gene expression
OT  - metabolism
OT  - obesity
EDAT- 2020/10/30 06:00
MHDA- 2022/02/11 06:00
CRDT- 2020/10/29 12:10
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2022/02/11 06:00 [medline]
PHST- 2020/10/29 12:10 [entrez]
AID - S2040174420000987 [pii]
AID - 10.1017/S2040174420000987 [doi]
PST - ppublish
SO  - J Dev Orig Health Dis. 2021 Oct;12(5):721-730. doi: 10.1017/S2040174420000987. 
      Epub 2020 Oct 29.