PMID- 33118952
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201120
IS  - 1929-0748 (Print)
IS  - 1929-0748 (Electronic)
IS  - 1929-0748 (Linking)
VI  - 9
IP  - 10
DP  - 2020 Oct 29
TI  - Effect of Testosterone Treatment on Cardiovascular Events in Men: Protocol for a 
      Systematic Literature Review and Meta-Analysis.
PG  - e15163
LID - 10.2196/15163 [doi]
LID - e15163
AB  - BACKGROUND: Testosterone prescriptions have increased dramatically in recent 
      decades, with increasing usage in men. Despite epidemiological associations 
      reported high circulating concentrations of endogenous androgens and low risk of 
      cardiovascular events and mortality, the effects of exogenous androgens in the 
      form of testosterone therapy for maintaining physiological circulating androgen 
      concentrations on the cardiovascular system remain uncertain with no published 
      meta-analysis on this topic. OBJECTIVE: The aim of this study was to investigate 
      the effects of prescribed testosterone treatment, in all forms and durations, 
      from well-developed randomized controlled trials, on cardiovascular events in men 
      aged 18 years or older. METHODS: Peer-reviewed journal articles published from 
      1980 to 2019 will be searched from databases (ie CINAHL [Cumulated Index to 
      Nursing and Allied Health Literature], Embase, Medline, Scopus, Cochrane 
      Controlled Register of Trials as well as the Clinical Trial Registry). Randomized 
      controlled trials or cluster randomized controlled trials with at least one 
      intervention arm of testosterone and a control group of usual care or no 
      testosterone treatment will be included in this review and meta-analysis. Studies 
      on men with previous cardiovascular events or cardiac vascularization (coronary 
      bypass surgery or percutaneous coronary intervention) will be excluded. Data 
      related to primary outcomes such as clinical events of any type of stroke or 
      transient ischemic attack, nonfatal myocardial infarction or acute coronary 
      syndrome, emergency coronary artery revascularization, carotid surgery, cardiac 
      mortality, and all-cause mortality will be extracted for analysis. The criteria 
      for PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 
      will be followed in the evaluation of evidence. RESULTS: Search terms have been 
      piloted and finalized. This study will be completed by the end of 2020. 
      CONCLUSIONS: This protocol will guide a systematic literature review of the 
      evidence around prescribed testosterone and its effect on cardiovascular events 
      in men aged 18 years or older. The findings will inform clinical management of 
      hypogonadal men. TRIAL REGISTRATION: PROSPERO International Prospective Register 
      of Systematic Reviews CRD42019134278; https://tinyurl.com/y6t7ggge. INTERNATIONAL 
      REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/15163.
CI  - (c)HuiJun Chih, Christopher M Reid, Bu B Yeap, Girish Dwivedi. Originally published 
      in JMIR Research Protocols (http://www.researchprotocols.org), 29.10.2020.
FAU - Chih, HuiJun
AU  - Chih H
AUID- ORCID: 0000-0001-9294-0996
AD  - School of Public Health, Curtin University, Perth, Australia.
FAU - Reid, Christopher M
AU  - Reid CM
AUID- ORCID: 0000-0001-9173-3944
AD  - School of Public Health, Curtin University, Perth, Australia.
AD  - School of Public Health & Preventative Medicine, Monash University, Melbourne, 
      Australia.
FAU - Yeap, Bu B
AU  - Yeap BB
AUID- ORCID: 0000-0002-7612-5892
AD  - Medical School, University of Western Australia, Perth, Australia.
AD  - Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, 
      Australia.
FAU - Dwivedi, Girish
AU  - Dwivedi G
AUID- ORCID: 0000-0003-0717-740X
AD  - Medical School, University of Western Australia, Perth, Australia.
AD  - Harry Perkins Institute of Medical Research, University of Western Australia, 
      Perth, Australia.
AD  - Department of Cardiology, Fiona Stanley Hospital, Perth, Australia.
LA  - eng
PT  - Journal Article
DEP - 20201029
PL  - Canada
TA  - JMIR Res Protoc
JT  - JMIR research protocols
JID - 101599504
PMC - PMC7661242
OTO - NOTNLM
OT  - cardiac mortality
OT  - carotid surgery
OT  - emergency revascularization
OT  - exogenous testosterone
OT  - nonfatal myocardial infarction
OT  - stroke
COIS- Conflicts of Interest: None declared.
EDAT- 2020/10/30 06:00
MHDA- 2020/10/30 06:01
PMCR- 2020/10/29
CRDT- 2020/10/29 12:11
PHST- 2019/06/24 00:00 [received]
PHST- 2020/02/28 00:00 [accepted]
PHST- 2020/02/27 00:00 [revised]
PHST- 2020/10/29 12:11 [entrez]
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2020/10/30 06:01 [medline]
PHST- 2020/10/29 00:00 [pmc-release]
AID - v9i10e15163 [pii]
AID - 10.2196/15163 [doi]
PST - epublish
SO  - JMIR Res Protoc. 2020 Oct 29;9(10):e15163. doi: 10.2196/15163.