PMID- 33119467
OWN - NLM
STAT- MEDLINE
DCOM- 20210629
LR  - 20220531
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 130
IP  - 1
DP  - 2021 Jan 1
TI  - Influence of prostaglandins and endothelial-derived hyperpolarizing factors on 
      brachial and popliteal endothelial-dependent function in young adults.
PG  - 17-25
LID - 10.1152/japplphysiol.00698.2020 [doi]
AB  - Heterogeneous flow-mediated dilation (FMD) and low-flow-mediated constriction 
      (L-FMC) responses have been reported between upper- and lower-limb arteries. 
      Radial artery L-FMC, but not FMD, responses are blunted when endothelial-derived 
      hyperpolarizing factors (EDHFs) or prostaglandin production is inhibited in young 
      adults. However, it is unknown if these mechanisms similarly impact 
      endothelial-dependent responses in the brachial (BA) and popliteal (POP) 
      arteries. We tested whether BA- and POP-L-FMC and FMD would be influenced by 
      independent EDHF and prostaglandin inhibition. Eighteen participants (23 +/- 3 yr; 
      6female symbol) completed three randomized and double-blinded ultrasound assessments 
      following ingestion of an opaque capsule containing maltodextrin (control), 
      150 mg of fluconazole (EDHF inhibition), or 500 mg of aspirin (prostaglandin 
      inhibition). POP resting diameter was reduced following fluconazole 
      administration (6.13 +/- 0.63 mm vs. 6.19 +/- 0.65 mm in control, P = 0.03). Compared 
      with control, fluconazole also blunted the relative L-FMC responses in both the 
      BA (-2.1 +/- 0.8% vs. -0.8 +/- 1.0%, P = 0.001) and POP (-1.7 +/- 1.1% vs. -0.8 +/- 0.9%, 
      P = 0.009). In contrast, aspirin did not impact either the BA (-1.9 +/- 0.7%) or 
      POP-L-FMC (-1.3 +/- 0.6%) responses (both, P > 0.35). The FMD response was 
      unchanged following fluconazole or aspirin administration in either artery (both, 
      P > 0.36). Our findings demonstrate that EDHF mediates L-FMC responses in both 
      the brachial and popliteal arteries. Complementary to the nitric oxide-mediated 
      FMD response, L-FMC appears to provide information regarding the EDHF pathway. 
      Future research should uncover if these mechanisms impact older adults and/or 
      patient populations characterized by vascular endothelial dysfunction associated 
      with low aerobic fitness and habitual physical activity levels.NEW & NOTEWORTHY 
      We compared changes in upper- and lower-limb artery endothelial-dependent 
      vasodilatory and vasoconstrictor responses between control, prostaglandin 
      inhibition, and endothelial-derived hyperpolarizing factor inhibition conditions. 
      Neither prostaglandins nor endothelial-derived hyperpolarizing factor influenced 
      flow-mediated dilation responses in either the brachial or popliteal artery. In 
      contrast, endothelial-derived hyperpolarizing factor, but not prostaglandins, 
      reduced resting brachial artery blood flow and shear rate and resting popliteal 
      artery diameter, as well as low-flow-mediated constriction responses in both the 
      popliteal and brachial arteries.
FAU - Petterson, Jennifer L
AU  - Petterson JL
AD  - Division of Kinesiology, Faculty of Health, School of Health and Human 
      Performance, Dalhousie University, Halifax, Nova Scotia, Canada.
FAU - O'Brien, Myles W
AU  - O'Brien MW
AD  - Division of Kinesiology, Faculty of Health, School of Health and Human 
      Performance, Dalhousie University, Halifax, Nova Scotia, Canada.
FAU - Johns, Jarrett A
AU  - Johns JA
AUID- ORCID: 0000-0002-8960-9685
AD  - Division of Kinesiology, Faculty of Health, School of Health and Human 
      Performance, Dalhousie University, Halifax, Nova Scotia, Canada.
FAU - Chiasson, Jack
AU  - Chiasson J
AD  - Division of Kinesiology, Faculty of Health, School of Health and Human 
      Performance, Dalhousie University, Halifax, Nova Scotia, Canada.
FAU - Kimmerly, Derek S
AU  - Kimmerly DS
AUID- ORCID: 0000-0002-3462-8037
AD  - Division of Kinesiology, Faculty of Health, School of Health and Human 
      Performance, Dalhousie University, Halifax, Nova Scotia, Canada.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20201029
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Prostaglandins)
SB  - IM
MH  - *Brachial Artery
MH  - Endothelium, Vascular
MH  - Humans
MH  - *Prostaglandins
MH  - Regional Blood Flow
MH  - Vasoconstriction
MH  - Vasodilation
MH  - Young Adult
OTO - NOTNLM
OT  - aspirin
OT  - flow-mediated dilation
OT  - fluconazole
OT  - low-flow-mediated constriction
EDAT- 2020/10/30 06:00
MHDA- 2021/06/30 06:00
CRDT- 2020/10/29 17:13
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2021/06/30 06:00 [medline]
PHST- 2020/10/29 17:13 [entrez]
AID - 10.1152/japplphysiol.00698.2020 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2021 Jan 1;130(1):17-25. doi: 
      10.1152/japplphysiol.00698.2020. Epub 2020 Oct 29.