PMID- 33119707
OWN - NLM
STAT- MEDLINE
DCOM- 20201215
LR  - 20201215
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 10
DP  - 2020
TI  - Early vascular modifications after endoscopic endonasal pituitary surgery: The 
      role of OCT-angiography.
PG  - e0241295
LID - 10.1371/journal.pone.0241295 [doi]
LID - e0241295
AB  - PURPOSE: The aim of the present study is to analyze the changes in retinal vessel 
      density (VD), using Optical Coherence Tomography Angiography (OCT-A), in patients 
      that received endoscopic endonasal approach for the removal of an 
      intra-suprasellar pituitary adenoma compressing optic chiasm. METHODS: We 
      evaluated the VD in Superficial Capillary Plexus (SCP), Deep Capillary Plexus 
      (DCP), Radial Peripapillary Capillary (RPC) and the Foveal Avascular Zone (FAZ) 
      area in a series of fourteen patients (7 males, 7 females, mean age 56 +/- 13 
      years), as compared to healthy controls. We also detected the structural Spectral 
      Domain (SD)-OCT parameters: Ganglion Cell Complex (GCC), Retinal Nerve Fiber 
      Layer (RNFL), visual field parameters (Mean Deviation, Pattern Standard 
      Deviation) and Best Corrected Visual Acuity (BCVA). These measurements were 
      performed prior than surgery and 48 hours after. RESULTS: The patients showed a 
      significant decrease in VD of the macular and papillary regions, a significant 
      increase in FAZ area, a significant impairment in SD-OCT, VF parameters and BCVA 
      respect to 14 eyes of 14 healthy controls (p<0.05), at pre-op evaluation. In 
      patients group the VD in SCP, DCP and RPC increased after surgery respect to 
      baseline but the difference turned to be out statistically significant only in 
      RPC (p = 0.003). Also the BCVA (p = 0.040) and the Mean Deviation at visual field 
      (p = 0.015) significantly improved after surgery. While there was a reduction in 
      structural OCT parameters but it was statistically significant only in GCC (p = 
      0.039). A positive correlation was found between the preoperative VD of the RPC, 
      Mean Deviation, BCVA and the postoperative Mean Deviation (r = 0.426 p = 0.027; r 
      = 0.624 p = 0.001; r = 0.515 p = 0.006). CONCLUSION: OCT-A allows to detect the 
      early changes occurring within 48 hours after surgery showing that the 
      improvement in retinal vessel density could occur before the recovery of the 
      structural OCT parameters and can be a positive predictive factor for the 
      functional recovery.
FAU - Cennamo, Gilda
AU  - Cennamo G
AUID- ORCID: 0000-0003-4253-1929
AD  - Public Health Department, University of Naples "Federico II", Naples, Italy.
FAU - Solari, Domenico
AU  - Solari D
AD  - Division of Neurosurgery, Department of Neurosciences, Reproductive Sciences and 
      Dentistry, University of Naples "Federico II", Naples, Italy.
FAU - Montorio, Daniela
AU  - Montorio D
AD  - Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, 
      University of Naples "Federico II", Naples, Italy.
FAU - Scala, Maria Rosaria
AU  - Scala MR
AD  - Division of Neurosurgery, Department of Neurosciences, Reproductive Sciences and 
      Dentistry, University of Naples "Federico II", Naples, Italy.
FAU - Melenzane, Antonietta
AU  - Melenzane A
AD  - Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, 
      University of Naples "Federico II", Naples, Italy.
FAU - Fossataro, Federica
AU  - Fossataro F
AUID- ORCID: 0000-0001-5798-1899
AD  - Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, 
      University of Naples "Federico II", Naples, Italy.
FAU - Somma, Teresa
AU  - Somma T
AD  - Division of Neurosurgery, Department of Neurosciences, Reproductive Sciences and 
      Dentistry, University of Naples "Federico II", Naples, Italy.
FAU - Tranfa, Fausto
AU  - Tranfa F
AD  - Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, 
      University of Naples "Federico II", Naples, Italy.
FAU - Cavallo, Luigi Maria
AU  - Cavallo LM
AD  - Division of Neurosurgery, Department of Neurosciences, Reproductive Sciences and 
      Dentistry, University of Naples "Federico II", Naples, Italy.
LA  - eng
PT  - Journal Article
DEP - 20201029
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Macula Lutea/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - *Pituitary Neoplasms/diagnostic imaging/surgery
MH  - Retinal Vessels/*diagnostic imaging
MH  - *Tomography, Optical Coherence
MH  - *Transanal Endoscopic Surgery
PMC - PMC7595382
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/10/30 06:00
MHDA- 2020/12/16 06:00
PMCR- 2020/10/29
CRDT- 2020/10/29 17:14
PHST- 2020/06/16 00:00 [received]
PHST- 2020/10/12 00:00 [accepted]
PHST- 2020/10/29 17:14 [entrez]
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2020/12/16 06:00 [medline]
PHST- 2020/10/29 00:00 [pmc-release]
AID - PONE-D-20-18484 [pii]
AID - 10.1371/journal.pone.0241295 [doi]
PST - epublish
SO  - PLoS One. 2020 Oct 29;15(10):e0241295. doi: 10.1371/journal.pone.0241295. 
      eCollection 2020.