PMID- 3311975
OWN - NLM
STAT- MEDLINE
DCOM- 19871204
LR  - 20190824
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 15
IP  - 3
DP  - 1987 Jul
TI  - Immunology of elastin: study of anti-elastin peptide antibodies by DOT 
      immunobinding assay.
PG  - 187-92
AB  - In order to further investigate the role of the immune system in the 
      arteriosclerotic process, we investigated the anti-elastin peptide antibodies 
      (AEAb) of the IgG and IgM types by DOT immunobinding assay in the sera of 
      patients suffering from various arteriosclerotic diseases. In total 232 control 
      and pathological sera were studied. In obliterative arteriosclerosis of the legs 
      90%, ischemic heart disease 67% and hypertension 60% of sera were positive for 
      AEAb of the IgG type independent of age. In the case of diabetes mellitus, 
      however, the duration of the disease was determinant. In rheumatoid arthritis, 
      the results were negative. No clear-cut positivity could be demonstrated in 
      stroke patients either. These results indicate that AEAb can be detected in some 
      diseases and DOT appears to be an appropriate method for the AEAb screening in 
      various diseases.
FAU - Bako, G
AU  - Bako G
AD  - First Department of Medicine, University Medical School of Debrecen, Hungary.
FAU - Jacob, M P
AU  - Jacob MP
FAU - Fulop, T Jr
AU  - Fulop T Jr
FAU - Foris, G
AU  - Foris G
FAU - Leovey, A
AU  - Leovey A
FAU - Robert, L
AU  - Robert L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Peptide Fragments)
RN  - 9007-58-3 (Elastin)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Arteriosclerosis/*immunology
MH  - Arthritis, Rheumatoid/immunology
MH  - Coronary Disease/immunology
MH  - Diabetes Mellitus/immunology
MH  - Elastin/*immunology
MH  - Female
MH  - Humans
MH  - Hypertension/immunology
MH  - Immunoglobulin G/analysis
MH  - Immunoglobulin M/analysis
MH  - Immunosorbent Techniques
MH  - Male
MH  - Middle Aged
MH  - Peptide Fragments/immunology
EDAT- 1987/07/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1987/07/01 00:00
PHST- 1987/07/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1987/07/01 00:00 [entrez]
AID - 0165-2478(87)90023-X [pii]
AID - 10.1016/0165-2478(87)90023-x [doi]
PST - ppublish
SO  - Immunol Lett. 1987 Jul;15(3):187-92. doi: 10.1016/0165-2478(87)90023-x.