PMID- 33119874
OWN - NLM
STAT- MEDLINE
DCOM- 20210113
LR  - 20210113
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1273
DP  - 2020
TI  - Dendritic Cells in the Tumor Microenvironment.
PG  - 29-38
LID - 10.1007/978-3-030-49270-0_2 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells (APCs) of the 
      immune system. They capture foreign antigens and can present them to lymphocytes, 
      that is, T cells and B cells, to activate them. DCs are the most potent of all 
      immune cells at inducing the adaptive immune system. Thus, the presence of DCs at 
      the anatomical site of the immune challenge is imperative for the immune system 
      to mount an effective immune response. From the anatomical site of the immune 
      challenge, DCs cargo antigens to the draining lymph nodes, specialized immune 
      organs where adaptive immunity is generated. DCs are heterogeneous as a type of 
      immune cell, and various subsets of DCs have been reported and their functions 
      described. In this chapter, we discuss various aspects of DC development and 
      function. We further discuss how various tumor microenvironments can affect DC 
      development, function, and migration, thus evading a strong adaptive immune 
      response.
FAU - Kohli, Karan
AU  - Kohli K
AD  - Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 
      USA.
FAU - Pillarisetty, Venu G
AU  - Pillarisetty VG
AD  - Department of Surgery, University of Washington, Seattle, WA, USA. vgp@uw.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - Adaptive Immunity
MH  - Cell Movement
MH  - Dendritic Cells/*cytology/immunology
MH  - Humans
MH  - Neoplasms/*immunology
MH  - Tumor Microenvironment/*immunology
OTO - NOTNLM
OT  - Anti-tumor immunity
OT  - Antigen-presenting cells
OT  - Chemotaxis
OT  - Cytokines
OT  - Danger signal
OT  - Dendritic cells
OT  - Development
OT  - Immunosuppression
OT  - Longevity
OT  - Lymph nodes
OT  - Migration
OT  - Subsets
OT  - Tertiary lymphoid organs
OT  - Toll-like receptors
OT  - Tumor microenvironment
EDAT- 2020/10/30 06:00
MHDA- 2021/01/14 06:00
CRDT- 2020/10/29 17:16
PHST- 2020/10/29 17:16 [entrez]
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2021/01/14 06:00 [medline]
AID - 10.1007/978-3-030-49270-0_2 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2020;1273:29-38. doi: 10.1007/978-3-030-49270-0_2.