PMID- 33119901
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 1099-0801 (Electronic)
IS  - 0269-3879 (Linking)
VI  - 35
IP  - 7
DP  - 2021 Jul
TI  - Plasma amino acid metabolomic pattern in heart failure patients with either 
      preserved or reduced ejection fraction: The relation to established risk 
      variables and prognosis.
PG  - e5012
LID - 10.1002/bmc.5012 [doi]
AB  - Communication between amino acids (AAs) and heart failure (HF) is unclear. We 
      evaluate the plasma metabolomic profile of AAs in HF and its subgroups and 
      association with clinical features. This is a case-control study in which 90 
      patients with HF, 63 with reduced ejection fraction (HFrEF) and 27 with preserved 
      ejection fraction (HFpEF), were compared with 60 controls. The quantitative 
      measurement of plasma concentrations of AA metabolites was performed using an AA 
      analyzer. Compared with controls, HF patients had significantly higher levels of 
      nine AAs and significantly lower levels of seven AAs. Leu, phenylalanine (Phe), 
      and methionine (Met) were the independent predictors of HF that remained 
      significant after adjustment for confounding factors in multivariate analysis. 
      There was a significant difference in 10 AAs and some clinical features between 
      HFpEF and HFrEF. The plasma levels of six AAs were significantly increased across 
      the different New York Heart Association (NYHA) classes, (class II, class III, 
      class IV) but they were not predictor of reduced EF and NYHA in multivariate 
      regression analysis. There were significant associations between Leu, Phe, and 
      Met with cardiovascular risk variables and prognosis. In conclusion, plasma Leu, 
      Phe, and Met provide early prediction and prognostic values of HF. The plasma AAs 
      could have significant impact on the risk-stratifying HFrEF and HFpEF and NYHA 
      functional class but do not predict them.
CI  - (c) 2020 John Wiley & Sons, Ltd.
FAU - Saleem, Tahia H
AU  - Saleem TH
AUID- ORCID: 0000-0001-8575-4714
AD  - Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, 
      Assiut University, Assiut, Egypt.
FAU - Algowhary, Magdy
AU  - Algowhary M
AUID- ORCID: 0000-0002-6806-9042
AD  - Department of Cardiology, Faculty of Medicine, Assiut University, Assiut, Egypt.
FAU - Kamel, Fatma Elzahraa M
AU  - Kamel FEM
AUID- ORCID: 0000-0001-9674-5901
AD  - Pharmacist at Cardiology Department, Faculty of Pharmacy, Assiut University, 
      Assiut, Egypt.
FAU - El-Mahdy, Reham I
AU  - El-Mahdy RI
AUID- ORCID: 0000-0003-4144-1868
AD  - Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, 
      Assiut University, Assiut, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20201115
PL  - England
TA  - Biomed Chromatogr
JT  - Biomedical chromatography : BMC
JID - 8610241
RN  - 0 (Amino Acids)
SB  - IM
MH  - Adult
MH  - Amino Acids/*blood/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - *Heart Failure/blood/diagnosis/metabolism/physiopathology
MH  - Humans
MH  - Male
MH  - Metabolome/*physiology
MH  - Middle Aged
MH  - Prognosis
MH  - Sensitivity and Specificity
MH  - Stroke Volume/physiology
OTO - NOTNLM
OT  - chromatography
OT  - heart failure
OT  - heart failure with preserved ejection fraction
OT  - heart failure with reduced ejection fraction
OT  - metabolomic profile
OT  - prediction
EDAT- 2020/10/30 06:00
MHDA- 2021/07/06 06:00
CRDT- 2020/10/29 17:16
PHST- 2020/10/08 00:00 [revised]
PHST- 2020/07/03 00:00 [received]
PHST- 2020/10/16 00:00 [accepted]
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2020/10/29 17:16 [entrez]
AID - 10.1002/bmc.5012 [doi]
PST - ppublish
SO  - Biomed Chromatogr. 2021 Jul;35(7):e5012. doi: 10.1002/bmc.5012. Epub 2020 Nov 15.