PMID- 33119966 OWN - NLM STAT- MEDLINE DCOM- 20211122 LR - 20211122 IS - 1475-1313 (Electronic) IS - 0275-5408 (Linking) VI - 41 IP - 1 DP - 2021 Jan TI - The effect of simultaneous dual-focus integration on the global flash multifocal electroretinogram in the human eye. PG - 171-178 LID - 10.1111/opo.12751 [doi] AB - PURPOSE: To investigate the effect of simultaneous dual-focus (DF) on retinal activities measured by global flash multifocal electroretinogram (mfERG). METHODS: Thirty adults were recruited for mfERG measurement under three conditions: in-focus (i.e., no defocus), +2.50 D DF and +7.50 D DF, administered using single vision contact lenses and DF lenses. The direct component (DC) and the induced component (IC) of the mfERG were pooled into central macular (0-8 degrees ), para-macular (8-18 degrees ) and peri-macular (18-30 degrees ) regions, and then compared across the three conditions using two-way, repeated measures ANOVA. RESULTS: Simultaneous DF had a significant effect on the IC amplitude, which was significantly stronger under +7.50 D DF (p < 0.01) than for the in-focus condition, which was mostly derived from the central and para-macular regions. No significant effect was observed for the +2.50 D DF condition. CONCLUSION: Under the effect of relatively strong simultaneous DF integration, the retina showed an enhanced retinal response, which originated from the inner retina. Compared with the peri-macular region, central and para-macular responses appeared to be enhanced. CI - (c) 2020 The Authors Ophthalmic and Physiological Optics (c) 2020 The College of Optometrists. FAU - Fung, Mavis M Y AU - Fung MMY AUID- ORCID: 0000-0002-1888-2043 AD - The Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Choi, Kai Yip AU - Choi KY AUID- ORCID: 0000-0002-0443-3028 AD - The Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China. AD - Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Chan, Henry H L AU - Chan HHL AUID- ORCID: 0000-0002-8516-4711 AD - The Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China. AD - Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China. AD - Centre for Eye and Vision Research, Hong Kong, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20201029 PL - England TA - Ophthalmic Physiol Opt JT - Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) JID - 8208839 SB - IM MH - Adult MH - Contact Lenses MH - Cross-Over Studies MH - *Electroretinography MH - Female MH - Humans MH - Male MH - *Photic Stimulation MH - Retina/*physiology MH - Young Adult OTO - NOTNLM OT - Myopia OT - contact lenses OT - electrophysiology OT - retina EDAT- 2020/10/30 06:00 MHDA- 2021/11/23 06:00 CRDT- 2020/10/29 17:16 PHST- 2020/04/06 00:00 [received] PHST- 2020/09/10 00:00 [accepted] PHST- 2020/10/30 06:00 [pubmed] PHST- 2021/11/23 06:00 [medline] PHST- 2020/10/29 17:16 [entrez] AID - 10.1111/opo.12751 [doi] PST - ppublish SO - Ophthalmic Physiol Opt. 2021 Jan;41(1):171-178. doi: 10.1111/opo.12751. Epub 2020 Oct 29.