PMID- 33119966
OWN - NLM
STAT- MEDLINE
DCOM- 20211122
LR  - 20211122
IS  - 1475-1313 (Electronic)
IS  - 0275-5408 (Linking)
VI  - 41
IP  - 1
DP  - 2021 Jan
TI  - The effect of simultaneous dual-focus integration on the global flash multifocal 
      electroretinogram in the human eye.
PG  - 171-178
LID - 10.1111/opo.12751 [doi]
AB  - PURPOSE: To investigate the effect of simultaneous dual-focus (DF) on retinal 
      activities measured by global flash multifocal electroretinogram (mfERG). 
      METHODS: Thirty adults were recruited for mfERG measurement under three 
      conditions: in-focus (i.e., no defocus), +2.50 D DF and +7.50 D DF, administered 
      using single vision contact lenses and DF lenses. The direct component (DC) and 
      the induced component (IC) of the mfERG were pooled into central macular (0-8 degrees ), 
      para-macular (8-18 degrees ) and peri-macular (18-30 degrees ) regions, and then compared across 
      the three conditions using two-way, repeated measures ANOVA. RESULTS: 
      Simultaneous DF had a significant effect on the IC amplitude, which was 
      significantly stronger under +7.50 D DF (p < 0.01) than for the in-focus 
      condition, which was mostly derived from the central and para-macular regions. No 
      significant effect was observed for the +2.50 D DF condition. CONCLUSION: Under 
      the effect of relatively strong simultaneous DF integration, the retina showed an 
      enhanced retinal response, which originated from the inner retina. Compared with 
      the peri-macular region, central and para-macular responses appeared to be 
      enhanced.
CI  - (c) 2020 The Authors Ophthalmic and Physiological Optics (c) 2020 The College of 
      Optometrists.
FAU - Fung, Mavis M Y
AU  - Fung MMY
AUID- ORCID: 0000-0002-1888-2043
AD  - The Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic 
      University, Hong Kong, China.
FAU - Choi, Kai Yip
AU  - Choi KY
AUID- ORCID: 0000-0002-0443-3028
AD  - The Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic 
      University, Hong Kong, China.
AD  - Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The 
      Hong Kong Polytechnic University, Hong Kong, China.
FAU - Chan, Henry H L
AU  - Chan HHL
AUID- ORCID: 0000-0002-8516-4711
AD  - The Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic 
      University, Hong Kong, China.
AD  - Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The 
      Hong Kong Polytechnic University, Hong Kong, China.
AD  - Centre for Eye and Vision Research, Hong Kong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201029
PL  - England
TA  - Ophthalmic Physiol Opt
JT  - Ophthalmic & physiological optics : the journal of the British College of 
      Ophthalmic Opticians (Optometrists)
JID - 8208839
SB  - IM
MH  - Adult
MH  - Contact Lenses
MH  - Cross-Over Studies
MH  - *Electroretinography
MH  - Female
MH  - Humans
MH  - Male
MH  - *Photic Stimulation
MH  - Retina/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Myopia
OT  - contact lenses
OT  - electrophysiology
OT  - retina
EDAT- 2020/10/30 06:00
MHDA- 2021/11/23 06:00
CRDT- 2020/10/29 17:16
PHST- 2020/04/06 00:00 [received]
PHST- 2020/09/10 00:00 [accepted]
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2021/11/23 06:00 [medline]
PHST- 2020/10/29 17:16 [entrez]
AID - 10.1111/opo.12751 [doi]
PST - ppublish
SO  - Ophthalmic Physiol Opt. 2021 Jan;41(1):171-178. doi: 10.1111/opo.12751. Epub 2020 
      Oct 29.