PMID- 33120192
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 174
DP  - 2020 Nov-Dec
TI  - Clinical, radiological, and pathological evaluation of "NSIP with OP overlap" 
      pattern compared with NSIP in patients with idiopathic interstitial pneumonias.
PG  - 106201
LID - S0954-6111(20)30341-3 [pii]
LID - 10.1016/j.rmed.2020.106201 [doi]
AB  - BACKGROUND: Nonspecific interstitial pneumonia (NSIP) and organizing pneumonia 
      (OP) are major subtypes of idiopathic interstitial pneumonias (IIPs) and closely 
      related to connective tissue diseases (CTDs). "NSIP with OP overlap" is a 
      controversial finding that has recently appeared in the criteria of interstitial 
      pneumonia with autoimmune features (IPAF). However, details of this controversial 
      entity are not well known. OBJECTIVE: To determine the frequency of "NSIP with OP 
      overlap" pattern in IIPs and to identify differences from idiopathic NSIP 
      (iNSIP). METHODS: In 524 patients with interstitial pneumonia from 39 institutes 
      who underwent surgical lung biopsy, 444 were diagnosed as IIPs by a 
      multidisciplinary discussion meeting via a cloud-based integrated database. Among 
      these patients, 44 (9.9%) who had iNSIP and 21 (4.7%) with 
      histopathologically-defined "NSIP with OP overlap" pattern (a pathological NSIP 
      and OP pattern, but without a UIP pattern) were retrospectively studied. RESULTS: 
      Patients with "NSIP with OP overlap" pattern showed a significantly greater 
      extent of consolidation (p < 0.001), more subpleural ground glass attenuation 
      (p = 0.036), and more peripheral + bronchovascular distribution (p = 0.009) on 
      high-resolution computed tomography than those with iNSIP. The incidences of 
      newly-developed CTDs during follow-up was similar between the groups and 
      polymyositis/dermatomyositis was the most frequent CTD in both groups. Nearly 
      half of the patients fulfilled IPAF criteria, but no significant difference was 
      found between iNSIP and "NSIP with OP overlap" pattern (47.7% vs. 42.9, 
      p = 0.712). The incidence of acute exacerbation and the survival rates were 
      similar between the groups. CONCLUSIONS: The incidence of "NSIP with OP overlap" 
      pattern is 4.7% in IIPs. The frequency of newly-developed CTDs during follow-up, 
      mainly polymyositis/dermatomyositis, the frequency of acute exacerbation, and the 
      survival rate in "NSIP with OP overlap" pattern are similar to those of iNSIP.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Enomoto, Noriyuki
AU  - Enomoto N
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan; Health Administration Center, Hamamatsu University 
      School of Medicine, Hamamatsu, Japan. Electronic address: norieno@hama-med.ac.jp.
FAU - Sumikawa, Hiromitsu
AU  - Sumikawa H
AD  - Department of Diagnostic Radiology, Sakai City Medical Centre, Osaka, Japan.
FAU - Sugiura, Hiroaki
AU  - Sugiura H
AD  - Department of Radiology, National Defense Medical College, Saitama, Japan.
FAU - Kitani, Masashi
AU  - Kitani M
AD  - Department of Pathology, National Hospital Organization Tokyo National Hospital, 
      Tokyo, Japan.
FAU - Tanaka, Tomonori
AU  - Tanaka T
AD  - Department of Diagnostic Pathology, Kobe University Hospital, Hyogo, Japan.
FAU - Hozumi, Hironao
AU  - Hozumi H
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Fujisawa, Tomoyuki
AU  - Fujisawa T
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Suda, Takafumi
AU  - Suda T
AD  - Second Division, Department of Internal Medicine, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
LA  - eng
PT  - Journal Article
DEP - 20201021
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Dermatomyositis
MH  - Diagnosis, Differential
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Idiopathic Interstitial Pneumonias/*diagnostic imaging/*pathology
MH  - Lung/*diagnostic imaging/*pathology
MH  - Male
MH  - Middle Aged
MH  - Polymyositis
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Idiopathic interstitial pneumonia
OT  - Interstitial pneumonia with autoimmune features
OT  - Nonspecific interstitial pneumonia
OT  - Organizing pneumonia
OT  - Unclassifiable interstitial pneumonia
EDAT- 2020/10/30 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/10/29 20:08
PHST- 2020/06/07 00:00 [received]
PHST- 2020/09/28 00:00 [revised]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2020/10/30 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/10/29 20:08 [entrez]
AID - S0954-6111(20)30341-3 [pii]
AID - 10.1016/j.rmed.2020.106201 [doi]
PST - ppublish
SO  - Respir Med. 2020 Nov-Dec;174:106201. doi: 10.1016/j.rmed.2020.106201. Epub 2020 
      Oct 21.