PMID- 33120778 OWN - NLM STAT- MEDLINE DCOM- 20201119 LR - 20210112 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 99 IP - 43 DP - 2020 Oct 23 TI - Comparative efficacy of bariatric surgery for type 2 diabetes mellitus: A protocol for systematic review and network meta-analysis. PG - e22755 LID - 10.1097/MD.0000000000022755 [doi] LID - e22755 AB - BACKGROUND: The comparative efficacy of bariatric surgical procedures for type 2 diabetes mellitus (T2DM) has not been completely elucidated. To investigate this question, we conduct a systematic review and network meta-analysis. METHODS: The protocol followed preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) checklist. Two review authors will independently search the PubMed, Embase (Ovid), and the Cochrane Central Register of Controlled Trials databases. The primary outcome is T2DM remission. The secondary outcomes include BMI, HbA1c (%), and percentage excess weight loss (% EWL). Results from the network meta-analysis will be presented as summary relative effect sizes (WMD or RR) and relative 95% CIs for each possible pair of treatments. Outcomes will be combined based on different periods of follow-up (12 months, 36 months, and 60 months). RESULTS: The results will provide useful information about the efficacy of bariatric surgical procedures in patients with T2DM. CONCLUSION: The findings of the study will be disseminated through peer-reviewed journal. INPLASY REGISTRATION NUMBER: INPLASY202050053. FAU - Wang, Xixiong AU - Wang X AUID- ORCID: 0000-0002-7784-678 AD - Department of surgical oncology, Boao Evergrande International Hospital, Qionghai. FAU - Chen, Cunren AU - Chen C AD - Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China. FAU - Zheng, Buping AU - Zheng B AD - Department of surgical oncology, Boao Evergrande International Hospital, Qionghai. FAU - Yang, Xiaolong AU - Yang X AD - Department of surgical oncology, Boao Evergrande International Hospital, Qionghai. FAU - Zhang, Xiaoxin AU - Zhang X AD - Department of surgical oncology, Boao Evergrande International Hospital, Qionghai. FAU - Yang, Chenchen AU - Yang C AD - Department of surgical oncology, Boao Evergrande International Hospital, Qionghai. LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - *Bariatric Surgery MH - Diabetes Mellitus, Type 2/*surgery MH - Humans MH - *Meta-Analysis as Topic MH - Network Meta-Analysis MH - *Research Design MH - *Systematic Reviews as Topic MH - Treatment Outcome PMC - PMC7581160 COIS- We declare that we have no conflicts of interest. EDAT- 2020/10/31 06:00 MHDA- 2020/11/20 06:00 PMCR- 2020/10/23 CRDT- 2020/10/30 01:01 PHST- 2020/10/30 01:01 [entrez] PHST- 2020/10/31 06:00 [pubmed] PHST- 2020/11/20 06:00 [medline] PHST- 2020/10/23 00:00 [pmc-release] AID - 00005792-202010230-00054 [pii] AID - MD-D-20-08976 [pii] AID - 10.1097/MD.0000000000022755 [doi] PST - ppublish SO - Medicine (Baltimore). 2020 Oct 23;99(43):e22755. doi: 10.1097/MD.0000000000022755.