PMID- 33120814
OWN - NLM
STAT- MEDLINE
DCOM- 20201231
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 43
DP  - 2020 Oct 23
TI  - Factors affecting the Apgar score of offsprings born to mothers suffering from 
      systemic lupus erythematosus.
PG  - e22843
LID - 10.1097/MD.0000000000022843 [doi]
LID - e22843
AB  - To reveal which disease activity parameters affect low Apgar scores of newborns, 
      which is considered as a predictive parameter for neurological development.We 
      examined retrospectively the data from 42 newborns who were delivered from 
      systemic lupus erythematosus (SLE) mothers from 2006 to 2019. We evaluated 
      whether the disease activity parameters, such as the achievement ratio of lupus 
      low disease activity state (LLDAS), SLE disease activities index (SLEDAI), 
      complement level, titer of anti-double stranded DNA (anti-dsDNA) antibody, 
      therapeutic agents were related with low Apgar scores of newborns.In 42 newborns, 
      adverse pregnancy outcomes, especially preterm birth (16.7%), low birth weight 
      (31.0%) light-for-date (11.9%) were associated with disease activity parameters 
      or prednisolone dose. Apgar scores at 1 minute were related with unachieved LLDAS 
      and the titer of anti-dsDNA antibody at first and third trimester, SLEDAI score 
      and complement level at third trimester, mean prednisolone dose. Apgar scores at 
      5 minutes were also associated with the titer of anti-dsDNA antibodies at first 
      and third trimester and mean prednisolone dose. Multivariate analysis showed only 
      high titer of anti-dsDNA antibody was significantly associated with low Apgar 
      score at both one minute and 5 minutes.In our retrospective study, high titer of 
      anti-dsDNA antibodies at first and third trimester was a risk factor for low 
      Apgar scores of newborns born to SLE mothers. We considered that high titer of 
      anti-dsDNA antibody influenced on childrens neurological development, therefore, 
      there is a need for long-term follow-up study of SLE offsprings.
FAU - Shimada, Hiromi
AU  - Shimada H
AUID- ORCID: 0000-0001-5792-9919
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and 
      Respiratory Medicine.
FAU - Kameda, Tomohiro
AU  - Kameda T
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and 
      Respiratory Medicine.
FAU - Kanenishi, Kenji
AU  - Kanenishi K
AD  - Department of Perinatology and Gynecology.
FAU - Miyatake, Nobuyuki
AU  - Miyatake N
AD  - Department of Hygiene, Faculty of Medicine, Kagawa University, Kagawa, Japan.
FAU - Nakashima, Shusaku
AU  - Nakashima S
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and 
      Respiratory Medicine.
FAU - Wakiya, Risa
AU  - Wakiya R
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and 
      Respiratory Medicine.
FAU - Kato, Mikiya
AU  - Kato M
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and 
      Respiratory Medicine.
FAU - Miyagi, Taichi
AU  - Miyagi T
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and 
      Respiratory Medicine.
FAU - Mansour, Mai Mahmoud Fahmry
AU  - Mansour MMF
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and 
      Respiratory Medicine.
FAU - Hata, Toshiyuki
AU  - Hata T
AD  - Department of Perinatology and Gynecology.
FAU - Kadowaki, Norimitsu
AU  - Kadowaki N
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and 
      Respiratory Medicine.
FAU - Dobashi, Hiroaki
AU  - Dobashi H
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and 
      Respiratory Medicine.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antibodies, Antinuclear)
SB  - IM
MH  - Adult
MH  - Antibodies, Antinuclear/blood/*immunology
MH  - *Apgar Score
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - Lupus Erythematosus, Systemic/complications/genetics/*immunology
MH  - Pregnancy
MH  - Pregnancy Complications/genetics/immunology
MH  - Premature Birth
MH  - Retrospective Studies
PMC - PMC7581183
COIS- The authors report no conflicts of interest.
EDAT- 2020/10/31 06:00
MHDA- 2021/01/01 06:00
PMCR- 2020/10/23
CRDT- 2020/10/30 01:01
PHST- 2020/10/30 01:01 [entrez]
PHST- 2020/10/31 06:00 [pubmed]
PHST- 2021/01/01 06:00 [medline]
PHST- 2020/10/23 00:00 [pmc-release]
AID - 00005792-202010230-00090 [pii]
AID - MD-D-20-04395 [pii]
AID - 10.1097/MD.0000000000022843 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Oct 23;99(43):e22843. doi: 
      10.1097/MD.0000000000022843.