PMID- 33120936
OWN - NLM
STAT- MEDLINE
DCOM- 20210329
LR  - 20231112
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 25
IP  - 21
DP  - 2020 Oct 27
TI  - Unraveling the Antioxidant, Binding and Health-Protecting Properties of Phenolic 
      Compounds of Beers with Main Human Serum Proteins: In Vitro and In Silico 
      Approaches.
LID - 10.3390/molecules25214962 [doi]
LID - 4962
AB  - Our recently published in vivo studies and growing evidence suggest that moderate 
      consumption of beer possesses several health benefits, including antioxidant and 
      cardiovascular effects. Although beer contains phenolic acids and flavonoids as 
      the major composition, and upon consumption, the levels of major components 
      increase in the blood, there is no report on how these beer components interact 
      with main human serum proteins. Thus, to address the interaction potential 
      between beer components and human serum proteins, the present study primarily 
      aims to investigate the components of beer from different industrial sources as 
      well as their mode of interaction through in silico analysis. The contents of the 
      bioactive compounds, antioxidant capacities and their influence on binding 
      properties of the main serum proteins in human metabolism (human serum albumin 
      (HSA), plasma circulation fibrinogen (PCF), C-reactive protein (CRP) and 
      glutathione peroxidase 3 (GPX3)) were studied. In vitro and in silico studies 
      indicated that phenolic substances presented in beer interact with the key 
      regions of the proteins to enhance their antioxidant and health properties. We 
      hypothesize that moderate consumption of beer could be beneficial for patients 
      suffering from coronary artery disease (CAD) and other health advantages by 
      regulating the serum proteins.
FAU - Shafreen, Raja Mohamed Beema
AU  - Shafreen RMB
AD  - Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, 
      Tamil Nadu 630003, India.
FAU - Lakshmi, Selvaraj Alagu
AU  - Lakshmi SA
AD  - Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, 
      Tamil Nadu 630003, India.
FAU - Pandian, Shunmugiah Karutha
AU  - Pandian SK
AD  - Department of Biotechnology, Alagappa University, Science Campus, Karaikudi, 
      Tamil Nadu 630003, India.
FAU - Park, Yong Seo
AU  - Park YS
AD  - Department of Horticultural Science, Mokpo National University, Muan, Jeonnam 
      534-729, Korea.
FAU - Kim, Young Mo
AU  - Kim YM
AD  - Department of Food Nutrition, Gwangju Health University, Gwangsan-gu, Gwangju 
      506-723, Korea.
FAU - Pasko, Pawel
AU  - Pasko P
AD  - Department of Food Chemistry and Nutrition, Jagiellonian University Medical 
      College, Krakow 30-688, Poland.
FAU - Deutsch, Joseph
AU  - Deutsch J
AD  - Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew 
      University of Jerusalem, Jerusalem 9112001, Israel.
FAU - Katrich, Elena
AU  - Katrich E
AD  - Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew 
      University of Jerusalem, Jerusalem 9112001, Israel.
FAU - Gorinstein, Shela
AU  - Gorinstein S
AUID- ORCID: 0000-0002-0621-8305
AD  - Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew 
      University of Jerusalem, Jerusalem 9112001, Israel.
LA  - eng
PT  - Journal Article
DEP - 20201027
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Antioxidants)
RN  - 0 (Blood Proteins)
RN  - 0 (Phenols)
SB  - IM
MH  - Antioxidants/analysis/metabolism
MH  - Beer/*analysis
MH  - Blood Proteins/chemistry/*metabolism
MH  - *Computer Simulation
MH  - *Health
MH  - Humans
MH  - Molecular Docking Simulation
MH  - Phenols/*analysis/*metabolism
MH  - Protein Binding
MH  - Protein Conformation
PMC - PMC7663678
OTO - NOTNLM
OT  - antioxidants
OT  - beer
OT  - binding
OT  - docking
OT  - health properties
OT  - phenolic compounds
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2020/10/31 06:00
MHDA- 2021/03/30 06:00
PMCR- 2020/10/27
CRDT- 2020/10/30 01:01
PHST- 2020/09/20 00:00 [received]
PHST- 2020/10/21 00:00 [revised]
PHST- 2020/10/22 00:00 [accepted]
PHST- 2020/10/30 01:01 [entrez]
PHST- 2020/10/31 06:00 [pubmed]
PHST- 2021/03/30 06:00 [medline]
PHST- 2020/10/27 00:00 [pmc-release]
AID - molecules25214962 [pii]
AID - molecules-25-04962 [pii]
AID - 10.3390/molecules25214962 [doi]
PST - epublish
SO  - Molecules. 2020 Oct 27;25(21):4962. doi: 10.3390/molecules25214962.