PMID- 33121451
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Oct 29
TI  - Prevalence of seropositivity of selected herpesviruses in patients with multiple 
      sclerosis in the North of Jordan.
PG  - 397
LID - 10.1186/s12883-020-01977-w [doi]
LID - 397
AB  - BACKGROUND: Multiple sclerosis (MS) is a neurological disease that is caused by 
      an autoimmune response that results in the neuron's demyelination in the central 
      nervous system. The exact etiology of MS is not clear; however, several 
      environmental and genetic factors are believed to participate in its initiation 
      and development, including exposure to viruses. This study aims to investigate 
      the association between the seropositivity and antibody titer of selected 
      herpesviruses and MS in Jordanian MS patients. METHOD: In this study, 55 MS 
      patients and 40 age- and gender-matching apparently healthy volunteers were 
      recruited from two main hospitals in the north of Jordan. MS patients were 
      grouped into three types of MS based on the clinical presentation of the disease. 
      Blood samples were collected from the participants and the IgG antibodies for 
      human herpesvirus 6 (HHV-6), Epstein-Barr virus (EBV) nuclear antigen (EBNA), EBV 
      viral capsid antigen (VCA) and varicella-zoster virus (VZV) were assayed by 
      ELISA. The prevalence of seropositivity and the antibody level for each of the 
      antibodies were compared between MS patients and controls and between the three 
      types of MS. RESULTS: There was no significant difference in the prevalence of 
      seropositivity and in the levels of antibodies for HHV-6, EBNA and VCA between MS 
      patients and controls and between the three types of MS. In contrast, the number 
      of seropositive patients and the level of IgG antibodies for VZV were 
      significantly higher in MS patients compared to the control. CONCLUSION: This 
      study showed that patients with MS in the north of Jordan were more likely to be 
      seropositive for VZV than the general population. Based on this finding, we 
      recommend further studies to evaluate the seropositivity to VZV to be carried out 
      in other parts of Jordan and the greater middle east to find out if there is a 
      correlation between MS and previous infection with VZV.
FAU - Kofahi, Raid M
AU  - Kofahi RM
AUID- ORCID: 0000-0002-9237-8048
AD  - Department of Neurosciences, Jordan University of Science and Technology, P.O. 
      Box 3030, Irbid, 22110, Jordan. rmkofahi@just.edu.jo.
FAU - Kofahi, Hassan M
AU  - Kofahi HM
AD  - Department of Medical Laboratory Sciences, Jordan University of Science and 
      Technology, Irbid, Jordan.
FAU - Sabaheen, Suhib
AU  - Sabaheen S
AD  - Department of Medical Laboratory Sciences, Jordan University of Science and 
      Technology, Irbid, Jordan.
FAU - Qawasmeh, Majdi Al
AU  - Qawasmeh MA
AD  - Department of Neurosciences, Jordan University of Science and Technology, P.O. 
      Box 3030, Irbid, 22110, Jordan.
FAU - Momani, Aiman
AU  - Momani A
AD  - Department of Neurosciences, Jordan University of Science and Technology, P.O. 
      Box 3030, Irbid, 22110, Jordan.
FAU - Yassin, Ahmed
AU  - Yassin A
AD  - Department of Neurosciences, Jordan University of Science and Technology, P.O. 
      Box 3030, Irbid, 22110, Jordan.
FAU - Alhayk, Kefah
AU  - Alhayk K
AD  - Department of Neurosciences, Jordan University of Science and Technology, P.O. 
      Box 3030, Irbid, 22110, Jordan.
FAU - El-Salem, Khalid
AU  - El-Salem K
AD  - Department of Neurosciences, Jordan University of Science and Technology, P.O. 
      Box 3030, Irbid, 22110, Jordan.
LA  - eng
PT  - Journal Article
DEP - 20201029
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/*blood
MH  - Epstein-Barr Virus Infections/epidemiology
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/immunology
MH  - Jordan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/blood/*virology
MH  - Prevalence
MH  - Roseolovirus Infections/epidemiology
MH  - Varicella Zoster Virus Infection/*epidemiology
MH  - Young Adult
PMC - PMC7596955
OTO - NOTNLM
OT  - Autoimmunity
OT  - Jordan
OT  - Middle East
OT  - Multiple sclerosis
OT  - Varicella
COIS- The authors declare that they have no competing interests.
EDAT- 2020/10/31 06:00
MHDA- 2021/01/12 06:00
PMCR- 2020/10/29
CRDT- 2020/10/30 05:32
PHST- 2020/05/02 00:00 [received]
PHST- 2020/10/23 00:00 [accepted]
PHST- 2020/10/30 05:32 [entrez]
PHST- 2020/10/31 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/10/29 00:00 [pmc-release]
AID - 10.1186/s12883-020-01977-w [pii]
AID - 1977 [pii]
AID - 10.1186/s12883-020-01977-w [doi]
PST - epublish
SO  - BMC Neurol. 2020 Oct 29;20(1):397. doi: 10.1186/s12883-020-01977-w.