PMID- 33121791
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210125
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 763
DP  - 2021 Apr 1
TI  - Typical organic pollutant-protein interactions studies through spectroscopy, 
      molecular docking and crystallography: A review.
PG  - 142959
LID - S0048-9697(20)36489-5 [pii]
LID - 10.1016/j.scitotenv.2020.142959 [doi]
AB  - With the development of industry and human society, more attention was paid for 
      the toxic effects of organic pollutants that are closely related to human daily 
      life. Previous studies mainly focused on the dose-response relationship and 
      cytotoxic effects of pollutants to organisms，while little research focused on 
      pollutant-protein interactions at molecular level. However, the binding of 
      organic pollutants to biomolecules, especially proteins like transporters, 
      membrane receptor and nuclear receptors, is often the first step of toxic 
      effects. It can make a series of endocrine disrupting and genotoxic effects 
      through cell signaling pathway by binding specific target proteins including 
      serum albumin, thyroid transporter, estrogen receptor, androgen receptor, and 
      aryl hydrocarbon receptor. Thus, the research of interactions between organic 
      pollutants and proteins is helpful and necessary to understand the distribution, 
      metabolism and toxicity mechanism of compounds in organisms at the molecular 
      level. This paper reviewed the latest research progress of the interaction types 
      of persistent organic pollutants (POPs), emerging pollutants and some other 
      pollutants with targeted proteins. In addition, we summarized several main 
      experimental techniques for studying pollutant-protein interactions including 
      ultraviolet/visible absorption spectrometry (UV-vis), fluorescence, infrared 
      spectrometry, circular dichroic spectra (CD), molecular docking and X-ray 
      crystallography. This review contributes to the molecular mechanism of the 
      interaction between organic pollutants and biomolecules.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Tu, Mengchen
AU  - Tu M
AD  - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese 
      Research Academy of Environmental Sciences, Beijing 100012, China.
FAU - Zheng, Xin
AU  - Zheng X
AD  - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese 
      Research Academy of Environmental Sciences, Beijing 100012, China.
FAU - Liu, Peiyuan
AU  - Liu P
AD  - School of Life Sciences, Tianjin University, Tianjin, 300072, China.
FAU - Wang, Shuping
AU  - Wang S
AD  - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese 
      Research Academy of Environmental Sciences, Beijing 100012, China.
FAU - Yan, Zhenguang
AU  - Yan Z
AD  - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese 
      Research Academy of Environmental Sciences, Beijing 100012, China. Electronic 
      address: zgyan@craes.org.cn.
FAU - Sun, Qianhang
AU  - Sun Q
AD  - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese 
      Research Academy of Environmental Sciences, Beijing 100012, China; College of 
      Fisheries, Henan Normal University, Xinxiang 453007, China.
FAU - Liu, Xinyu
AU  - Liu X
AD  - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese 
      Research Academy of Environmental Sciences, Beijing 100012, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201014
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Binding Sites
MH  - Crystallography
MH  - *Environmental Pollutants/toxicity
MH  - Humans
MH  - Molecular Docking Simulation
MH  - Protein Binding
MH  - Spectrometry, Fluorescence
MH  - Spectrophotometry, Ultraviolet
MH  - Thermodynamics
OTO - NOTNLM
OT  - Interaction
OT  - Molecular docking
OT  - Organic pollutants
OT  - Protein
OT  - Spectroscopic methods
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interestsor personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/10/31 06:00
MHDA- 2021/01/26 06:00
CRDT- 2020/10/30 05:34
PHST- 2020/08/22 00:00 [received]
PHST- 2020/09/29 00:00 [revised]
PHST- 2020/10/08 00:00 [accepted]
PHST- 2020/10/31 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/10/30 05:34 [entrez]
AID - S0048-9697(20)36489-5 [pii]
AID - 10.1016/j.scitotenv.2020.142959 [doi]
PST - ppublish
SO  - Sci Total Environ. 2021 Apr 1;763:142959. doi: 10.1016/j.scitotenv.2020.142959. 
      Epub 2020 Oct 14.