PMID- 33122037
OWN - NLM
STAT- MEDLINE
DCOM- 20211001
LR  - 20211001
IS  - 1095-6840 (Electronic)
IS  - 0016-6480 (Linking)
VI  - 301
DP  - 2021 Jan 15
TI  - Sexually dimorphic effects of prolactin treatment on the onset of puberty and 
      olfactory function in mice.
PG  - 113652
LID - S0016-6480(20)30405-6 [pii]
LID - 10.1016/j.ygcen.2020.113652 [doi]
AB  - The onset of puberty is associated with the psychophysiological maturation of the 
      adolescent to an adult capable of reproduction when olfactory signals play an 
      important role. This period begins with the secretion of the 
      gonadotropin-releasing hormone (GnRH) from GnRH neurons within the hypothalamus. 
      This is regulated by kisspeptin neurons that express high levels of transmembrane 
      prolactin receptors (PRLR) that bind to and are activated by prolactin (PRL). The 
      elevated levels of serum PRL found during lactation, or caused by chronic PRL 
      infusion, decreases the secretion of gonadotropins and kisspeptin and compromised 
      the estrous cyclicity and the ovulation. In the present work, we aimed to 
      evaluate the effects of either increased or decreased PRL circulating levels 
      within the peripubertal murine brain by administration of PRL or treatment with 
      cabergoline (Cab) respectively. We showed that either treatment delayed the onset 
      of puberty in females, but not in males. This was associated with the 
      augmentation of the PRL receptor (Prlr) mRNA expression in the arcuate nucleus 
      and decreased Kiss1 expression in the anteroventral periventricular zone. Then, 
      during adulthood, we assessed the activation of the mitral and granular cells of 
      the main (MOB) and accessory olfactory bulb (AOB) by cFos immunoreactivity (ir) 
      after the exposure to soiled bedding of the opposite sex. In the MOB, the PRL 
      treatment promoted an increased cFos-ir of the mitral cells of males and females. 
      In the granular cells of male of either treatment an augmented activation was 
      observed. In the AOB, an impaired cFos-ir was observed in PRL and Cab treated 
      females after exposure to male soiled bedding. However, in males, only Cab 
      impaired its activation. No effects were observed in the AOB-mitral cells. In 
      conclusion, our results demonstrate that PRL contributes to pubertal development 
      and maturation of the MOB-AOB during the murine juvenile period in a 
      sex-dependent way.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Corona, Rebeca
AU  - Corona R
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Mexico. 
      Electronic address: rcorona@comunidad.unam.mx.
FAU - Jayakumar, Preethi
AU  - Jayakumar P
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Mexico.
FAU - Carbajo Mata, Maria Antonieta
AU  - Carbajo Mata MA
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Mexico.
FAU - Del Valle-Diaz, Maria Fernanda
AU  - Del Valle-Diaz MF
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Mexico.
FAU - Luna-Garcia, Luis Antonio
AU  - Luna-Garcia LA
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Mexico.
FAU - Morales, Teresa
AU  - Morales T
AD  - Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201026
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - 0 (Kisspeptins)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 9002-62-4 (Prolactin)
SB  - IM
MH  - Animals
MH  - Arcuate Nucleus of Hypothalamus/metabolism
MH  - Female
MH  - Gonadotropin-Releasing Hormone/metabolism
MH  - Hypothalamus/metabolism
MH  - Kisspeptins/genetics/metabolism
MH  - Male
MH  - Mice
MH  - Olfactory Cortex
MH  - Prolactin
MH  - Puberty
MH  - *Sexual Maturation
OTO - NOTNLM
OT  - Accessory olfactory bulb
OT  - Cabergoline
OT  - Granular cell layer
OT  - Internal cellular layer
OT  - Kiss1
OT  - Main olfactory bulb
OT  - Mitral cell layer
OT  - Prolactin
OT  - Puberty onset
EDAT- 2020/10/31 06:00
MHDA- 2021/10/02 06:00
CRDT- 2020/10/30 05:36
PHST- 2020/03/25 00:00 [received]
PHST- 2020/10/19 00:00 [revised]
PHST- 2020/10/22 00:00 [accepted]
PHST- 2020/10/31 06:00 [pubmed]
PHST- 2021/10/02 06:00 [medline]
PHST- 2020/10/30 05:36 [entrez]
AID - S0016-6480(20)30405-6 [pii]
AID - 10.1016/j.ygcen.2020.113652 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 2021 Jan 15;301:113652. doi: 10.1016/j.ygcen.2020.113652. 
      Epub 2020 Oct 26.