PMID- 33122744
OWN - NLM
STAT- MEDLINE
DCOM- 20210330
LR  - 20211204
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Oct 29
TI  - The correlation between plasma total homocysteine level and gestational diabetes 
      mellitus in a Chinese Han population.
PG  - 18679
LID - 10.1038/s41598-020-75797-w [doi]
LID - 18679
AB  - To assess the correlation between plasma total homocysteine (tHcy) level and 
      gestational diabetes mellitus (GDM) in a Chinese Han population. This 
      case-control study included 350 GDM patients and 346 gestational week-matched 
      normal glucose tolerance (NGT) pregnant women. Plasma tHcy and insulin levels 
      were analyzed by HPLC and ELISA respectively. Logistic regression analysis was 
      used to investigate the correlation between plasma tHcy level and risk of GDM. 
      Women with GDM had a higher plasma tHcy level than NGT women (6.61 +/- 1.32 vs. 
      6.17 +/- 1.29 mumol/L, P = 0.001)). The GDM risk was 1.79 (OR = 1.79, 95% CI 
      1.18-2.72, P = 0.006) times higher in women whose plasma tHcy level 
      was >/= 7.29 mumol/L compared to women with plasma tHcy level < 5.75 mumol/L. 
      Stratified analysis showed the GDM risk were much higher when HOMA-IR index >/= 2 
      (OR = 5.42, 95% CI 2.51-11.74, P < 0.001), age >/= 30 years (OR = 5.14, 95% CI 
      2.78-9.52, P < 0.001), or women with a family history of type 2 diabetes mellitus 
      (T2DM) (OR = 4.13, 95% CI 1.78-9.56, P = 0.001). In the Chinese Han population, 
      an elevated plasma tHcy level may increase the overall risk of GDM especially in 
      women with a high HOMA-IR index, increasing age or with family history of T2DM.
FAU - Deng, Mengyao
AU  - Deng M
AD  - Research Center for Health Promotion in Women, Youth and Children, Department of 
      Maternal, Child and Adolescent Health, School of Medicine, Wuhan University of 
      Science and Technology, Wuhan, 430065, China.
FAU - Zhou, Jia
AU  - Zhou J
AD  - Research Center for Health Promotion in Women, Youth and Children, Department of 
      Maternal, Child and Adolescent Health, School of Medicine, Wuhan University of 
      Science and Technology, Wuhan, 430065, China.
FAU - Tang, Zhao
AU  - Tang Z
AD  - Research Center for Health Promotion in Women, Youth and Children, Department of 
      Maternal, Child and Adolescent Health, School of Medicine, Wuhan University of 
      Science and Technology, Wuhan, 430065, China.
FAU - Xiang, Jun
AU  - Xiang J
AD  - Research Center for Health Promotion in Women, Youth and Children, Department of 
      Maternal, Child and Adolescent Health, School of Medicine, Wuhan University of 
      Science and Technology, Wuhan, 430065, China.
FAU - Yi, Jing
AU  - Yi J
AD  - Research Center for Health Promotion in Women, Youth and Children, Department of 
      Maternal, Child and Adolescent Health, School of Medicine, Wuhan University of 
      Science and Technology, Wuhan, 430065, China.
FAU - Peng, Yushuang
AU  - Peng Y
AD  - Research Center for Health Promotion in Women, Youth and Children, Department of 
      Maternal, Child and Adolescent Health, School of Medicine, Wuhan University of 
      Science and Technology, Wuhan, 430065, China.
FAU - Di, Lihua
AU  - Di L
AD  - Research Center for Health Promotion in Women, Youth and Children, Department of 
      Maternal, Child and Adolescent Health, School of Medicine, Wuhan University of 
      Science and Technology, Wuhan, 430065, China.
FAU - Zhai, Xiaobing
AU  - Zhai X
AD  - Research Center for Health Promotion in Women, Youth and Children, Department of 
      Maternal, Child and Adolescent Health, School of Medicine, Wuhan University of 
      Science and Technology, Wuhan, 430065, China.
FAU - Yang, Mei
AU  - Yang M
AD  - Research Center for Health Promotion in Women, Youth and Children, Department of 
      Maternal, Child and Adolescent Health, School of Medicine, Wuhan University of 
      Science and Technology, Wuhan, 430065, China. yangmei88@wust.edu.cn.
FAU - Du, Yukai
AU  - Du Y
AD  - Department of Maternal and Child Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, China. duyukai513@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201029
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Insulin)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - China
MH  - Diabetes, Gestational/*blood/ethnology
MH  - *Ethnicity
MH  - Female
MH  - Glucose Tolerance Test
MH  - Homocysteine/*blood
MH  - Humans
MH  - Insulin/blood
MH  - Pregnancy
PMC - PMC7596467
COIS- The authors declare no competing interests.
EDAT- 2020/10/31 06:00
MHDA- 2021/03/31 06:00
PMCR- 2020/10/29
CRDT- 2020/10/30 05:49
PHST- 2020/02/14 00:00 [received]
PHST- 2020/10/19 00:00 [accepted]
PHST- 2020/10/30 05:49 [entrez]
PHST- 2020/10/31 06:00 [pubmed]
PHST- 2021/03/31 06:00 [medline]
PHST- 2020/10/29 00:00 [pmc-release]
AID - 10.1038/s41598-020-75797-w [pii]
AID - 75797 [pii]
AID - 10.1038/s41598-020-75797-w [doi]
PST - epublish
SO  - Sci Rep. 2020 Oct 29;10(1):18679. doi: 10.1038/s41598-020-75797-w.