PMID- 33123197
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220417
IS  - 1687-8450 (Print)
IS  - 1687-8469 (Electronic)
IS  - 1687-8450 (Linking)
VI  - 2020
DP  - 2020
TI  - Significance of Detection of the HER2 Gene and PD-1/PD-L1 in Gastric Cancer.
PG  - 8678945
LID - 10.1155/2020/8678945 [doi]
LID - 8678945
AB  - OBJECTIVE: To explore the relationship between the HER2 gene and PD-1/PD-L1 in 
      gastric cancer and its significance. METHODS: Immunohistochemistry (IHC) and 
      fluorescence in situ hybridization (FISH) were used to detect HER2 protein 
      expression, HER2 gene amplification, and PD-1/PD-L1 expression in 78 cases of 
      gastric cancer. RESULTS: The expression rate of HER2 protein was 43.6% (34/78), 
      of which 19.4% (14/78) were HER2 3+, 14.1% (11/78) were HER2 2+, and 11.5% (9/78) 
      were HER2 1+. The results showed that 19.2% (15/78) of samples had HER2 gene 
      amplification, 3.8% (3/78) of samples had a HER2/CEP17 ratio <2.0, and 19.2% 
      (15/78) of samples had HER2 gene amplificationf and HER2 copy/cell >/=6.0, as 
      detected by FISH. The positive rate of PD-L1 was 38.5% (30/78) in gastric cancer 
      cells and 50.0% (39/78) in interstitial lymphocytes. The expression of the HER2 
      gene, PD-L1, and PD-1 in gastric cancer was correlated with the stage and lymph 
      node metastasis of gastric cancer (P < 0.05). CONCLUSIONS: The combined detection 
      of the HER2 gene and PD-1/PD-L1 in gastric cancer provides an important reference 
      index for the prognosis of gastric cancer and the benefit of targeted antitumor 
      drugs.
CI  - Copyright (c) 2020 Tian Yun et al.
FAU - Yun, Tian
AU  - Yun T
AUID- ORCID: 0000-0003-3015-2577
AD  - People's Liberation Army Joint Logistic Support Force 989th Hospital, LuoYang, 
      Henan 471031, China.
FAU - Wang, Sunan
AU  - Wang S
AD  - ShenZhen Polytechnic, ShenZhen 518110, China.
FAU - Jiang, Bo
AU  - Jiang B
AD  - People's Liberation Army Joint Logistic Support Force 990th Hospital, ZhuMaDian, 
      Henan 463000, China.
FAU - Wang, Changsong
AU  - Wang C
AD  - People's Liberation Army Joint Logistic Support Force 989th Hospital, LuoYang, 
      Henan 471031, China.
FAU - Meng, Nianlong
AU  - Meng N
AD  - People's Liberation Army Joint Logistic Support Force 989th Hospital, LuoYang, 
      Henan 471031, China.
FAU - Yuan, Xutao
AU  - Yuan X
AD  - People's Liberation Army Joint Logistic Support Force 989th Hospital, LuoYang, 
      Henan 471031, China.
FAU - Wang, Yangkun
AU  - Wang Y
AUID- ORCID: 0000-0002-9970-3093
AD  - Department of Pathology, ShenZhen Hospital, Southern Medical University, ShenZhen 
      518110, China.
LA  - eng
PT  - Journal Article
DEP - 20201013
PL  - Egypt
TA  - J Oncol
JT  - Journal of oncology
JID - 101496537
PMC - PMC7584973
COIS- The authors declare that they have no conflicts of interest to this work.
EDAT- 2020/10/31 06:00
MHDA- 2020/10/31 06:01
PMCR- 2020/10/13
CRDT- 2020/10/30 05:54
PHST- 2020/06/07 00:00 [received]
PHST- 2020/08/05 00:00 [revised]
PHST- 2020/09/29 00:00 [accepted]
PHST- 2020/10/30 05:54 [entrez]
PHST- 2020/10/31 06:00 [pubmed]
PHST- 2020/10/31 06:01 [medline]
PHST- 2020/10/13 00:00 [pmc-release]
AID - 10.1155/2020/8678945 [doi]
PST - epublish
SO  - J Oncol. 2020 Oct 13;2020:8678945. doi: 10.1155/2020/8678945. eCollection 2020.