PMID- 33123327
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201031
IS  - 2008-5117 (Print)
IS  - 2008-6830 (Electronic)
IS  - 2008-5117 (Linking)
VI  - 12
IP  - 3
DP  - 2020
TI  - Pregnancy outcome in women with mechanical prosthetic heart valvesat their first 
      trimester of pregnancy treated with unfractionated heparin (UFH) or enoxaparin: A 
      randomized clinical trial.
PG  - 209-213
LID - 10.34172/jcvtr.2020.35 [doi]
AB  - Introduction: Pregnancy increases the risks of thromboembolism for the mother and 
      fetus in patients with mechanical heart valves. The results of some studies have 
      indicated that low molecular weight heparin (LMWH), in comparison with 
      unfractionated heparin (UFH), leads to a lower incidence rate of thrombocytopenia 
      and a decrease in bleeding. Methods: The present randomized clinical trial 
      involved 31 pregnant women with mechanical heart valves at their first trimester 
      (0-14 weeks) of pregnancy. To perform the study, the patients were divided into 
      two groups, i.e. group A (LMWH group-16 patients) and group B (UFH group-15 
      patients). The birth weight, mode of delivery, and gestational age at birth as 
      well as the maternal and fetal complications were compared between the two 
      groups. Results: The mean age of mothers in the UFH and LMWH groups was 
      32.67+/-9.11 and 31.50+/-5.81years, respectively (P value > 0.05). Although the rate 
      of maternal and fetal complications was higher in the UFH group as compared with 
      the LMWH group, the observed difference was not significant (P value > 0.05). 
      Conclusion: LMWH can be regarded as a safer therapy for both the mother and fetus 
      due to its lower number of refill prescriptions and fewer changes in the blood 
      level.
CI  - (c) 2020 The Author(s).
FAU - Movahedi, Minoo
AU  - Movahedi M
AD  - Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Motamedi, Maryam
AU  - Motamedi M
AUID- ORCID: 0000-0002-3829-5372
AD  - Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Sajjadieh, Amirreza
AU  - Sajjadieh A
AUID- ORCID: 0000-0001-6383-5660
AD  - Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, 
      Iran.
FAU - Bahrami, Parvin
AU  - Bahrami P
AUID- ORCID: 0000-0003-4506-027X
AD  - Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, 
      Iran.
FAU - Saeedi, Mahmood
AU  - Saeedi M
AD  - Department of Cardiac Surgery, Isfahan University of Medical Sciences, Isfahan, 
      Iran.
FAU - Saeedi, Milad
AU  - Saeedi M
AD  - Department of General Medicine, Isfahan University of Medical Sciences, Isfahan, 
      Iran.
LA  - eng
PT  - Journal Article
DEP - 20200905
PL  - Iran
TA  - J Cardiovasc Thorac Res
JT  - Journal of cardiovascular and thoracic research
JID - 101528712
PMC - PMC7581847
OTO - NOTNLM
OT  - Low Molecular Weight Heparin
OT  - Mechanical Heart Valves
OT  - Pregnancy
OT  - Unfractionated Heparin
EDAT- 2020/10/31 06:00
MHDA- 2020/10/31 06:01
PMCR- 2020/01/01
CRDT- 2020/10/30 05:54
PHST- 2019/07/29 00:00 [received]
PHST- 2020/08/03 00:00 [accepted]
PHST- 2020/10/30 05:54 [entrez]
PHST- 2020/10/31 06:00 [pubmed]
PHST- 2020/10/31 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.34172/jcvtr.2020.35 [doi]
PST - ppublish
SO  - J Cardiovasc Thorac Res. 2020;12(3):209-213. doi: 10.34172/jcvtr.2020.35. Epub 
      2020 Sep 5.