PMID- 33125304
OWN - NLM
STAT- MEDLINE
DCOM- 20210106
LR  - 20211204
IS  - 1743-5404 (Electronic)
IS  - 1743-5390 (Linking)
VI  - 14
IP  - 9
DP  - 2020 Nov
TI  - Occupational exposure to graphene and silica nanoparticles. Part I: workplace 
      measurements and samplings.
PG  - 1280-1300
LID - 10.1080/17435390.2020.1834634 [doi]
AB  - Few-Layers Graphene (FLG) are able to improve the performance of materials, due 
      to their chemical-physical properties. Engineered amorphous silica nanoparticles 
      (SiO(2)NPs) are among the most widespread nanomaterials (NMs) in the world. Such 
      nanomaterials are two case studies of the research project 'NanoKey' that 
      integrated the exposure assessment through personal measurements and sampling in 
      the workplace, as described in the present work (part I), with the biomonitoring 
      of exposed workers (reported in part II). Measurement campaigns were conducted 
      according to OECD and WHO harmonized approach in two production sites. The set of 
      instruments included real-time devices for high-resolution measurements at the 
      nanoscale and time-integrated samplers for the off-line gravimetric analysis and 
      chemical and morphological (SEM-EDS) characterization of exposure in order to 
      identify the contribution of production compared to the background. Values of 
      particle number concentration (PNC) and lung deposited surface area (LDSA) within 
      the FLG production resulted higher than the background far field (FF), even if 
      they are always similar to the near field (NF) ones: the average diameter 
      (D(avg)) during the production was higher than the NF background but always lower 
      than the FF values. SEM-EDS analysis highlighted the presence of structures 
      comparable to those produced. During the SiO(2)NPs production, the PBZ values 
      showed PNC and LDSA levels higher than the background, with a decrease in the 
      D(avg) probably due to NPs emission. SEM-EDS confirms the presence of rare silica 
      nanoparticles. Since the exposure to airborne NMs cannot be excluded in both 
      production sites, a prevention-through-design approach to mitigate the potential 
      risk for workers has been recommended.
FAU - Boccuni, Fabio
AU  - Boccuni F
AD  - Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 
      Italian Workers' Compensation Authority (INAIL), Monte Porzio Catone, Rome, 
      Italy.
FAU - Ferrante, Riccardo
AU  - Ferrante R
AD  - Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 
      Italian Workers' Compensation Authority (INAIL), Monte Porzio Catone, Rome, 
      Italy.
FAU - Tombolini, Francesca
AU  - Tombolini F
AD  - Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 
      Italian Workers' Compensation Authority (INAIL), Monte Porzio Catone, Rome, 
      Italy.
FAU - Natale, Claudio
AU  - Natale C
AD  - Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 
      Italian Workers' Compensation Authority (INAIL), Monte Porzio Catone, Rome, 
      Italy.
FAU - Gordiani, Andrea
AU  - Gordiani A
AD  - Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 
      Italian Workers' Compensation Authority (INAIL), Monte Porzio Catone, Rome, 
      Italy.
FAU - Sabella, Stefania
AU  - Sabella S
AD  - Department of Drug Discovery and Development, Italian Institute of Technology 
      (IIT), Genova, Italy.
FAU - Iavicoli, Sergio
AU  - Iavicoli S
AD  - Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, 
      Italian Workers' Compensation Authority (INAIL), Monte Porzio Catone, Rome, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201030
PL  - England
TA  - Nanotoxicology
JT  - Nanotoxicology
JID - 101233132
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (FLG protein, human)
RN  - 0 (Filaggrin Proteins)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Air Pollutants, Occupational/*analysis
MH  - Biological Monitoring/methods
MH  - Filaggrin Proteins
MH  - Graphite/*analysis
MH  - Humans
MH  - Inhalation Exposure/*analysis
MH  - Italy
MH  - Laboratories/standards
MH  - Nanoparticles/*analysis
MH  - Occupational Exposure/*analysis
MH  - Particle Size
MH  - Silicon Dioxide/*analysis
MH  - Surface Properties
MH  - Workplace/*standards
OTO - NOTNLM
OT  - Nanotechnology
OT  - nanomaterials
OT  - prevention-through-design
OT  - risk assessment
OT  - workers
EDAT- 2020/10/31 06:00
MHDA- 2021/01/07 06:00
CRDT- 2020/10/30 17:12
PHST- 2020/10/31 06:00 [pubmed]
PHST- 2021/01/07 06:00 [medline]
PHST- 2020/10/30 17:12 [entrez]
AID - 10.1080/17435390.2020.1834634 [doi]
PST - ppublish
SO  - Nanotoxicology. 2020 Nov;14(9):1280-1300. doi: 10.1080/17435390.2020.1834634. 
      Epub 2020 Oct 30.