PMID- 33125667
OWN - NLM
STAT- MEDLINE
DCOM- 20210707
LR  - 20210707
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 199
IP  - 9
DP  - 2021 Sep
TI  - Evaluation of Cadmium Chloride-Induced Toxicity in Chicks Via Hematological, 
      Biochemical Parameters, and Cadmium Level in Tissues.
PG  - 3457-3469
LID - 10.1007/s12011-020-02453-9 [doi]
AB  - Cadmium is a heavy metal and a non-biodegradable environmental contaminant, and 
      its omnipresence ensures its recurrent exposure to humans and animals. Its intake 
      by chicks leads to fatal implications. Cadmium chloride (CdCl(2)) because of its 
      bio-accumulative nature is an emerging threat to the poultry industry as well as 
      to the humans which consumes these cadmium-intoxicated chickens. In the current 
      study, the target was to elucidate the toxic effects of CdCl(2)on body weight, 
      hematological, and biochemical parameters as well as its bioaccumulation in 
      different organs of broiler chicks. Various concentrations of CdCl(2) (0, 12, 24, 
      38, and 48 mg/kg body weight) were administered orally to five groups (A, B, C, 
      D, and E) of broiler chicks, respectively. The biometric screening of the exposed 
      birds was carried out by hematological parameters such as packed cell volume 
      (PCV), total erythrocyte count (TEC), mean corpuscular hemoglobin concentration 
      (MCHC), total protein, white blood cells (WBC), and hemoglobin (Hb), as well as 
      biochemical parameters superoxide dismutase (SOD), low-density lipoprotein (LDL), 
      glutathione peroxidase (GPx), and high-density lipoprotein (HDL) with 
      commercially available kits. Metal accumulation in different organs was detected 
      using atomic absorption spectrophotometer. The compound exposure produced a 
      varied impact on broiler birds. Hematological parameters showed a significant 
      decrease except for WBC. Biochemical parameters also decreased significantly in a 
      dose-dependent manner. However, it was revealed that the body weight of chickens 
      was not affected considerably after CdCl(2) exposure. A direct relationship was 
      detected between the accumulation of metal within tissues (lungs, heart, and 
      flesh) and exposure frequency. It can be deduced that an increase in Cd 
      deposition in tissues may lead to an alteration in hematological-biochemical 
      markers which may significantly contribute to systemic toxicity in broilers.
FAU - Ali, Shaukat
AU  - Ali S
AUID- ORCID: 0000-0003-2481-1978
AD  - Applied Entomology and Medical Toxicology, Department of Zoology, Government 
      College University, Lahore, Pakistan. dr.shaukatali@gcu.edu.pk.
FAU - Bashir, Saleha
AU  - Bashir S
AD  - Department of Zoology, The University of Azad Jammu and Kashmir, Muzaffarabad, 
      Pakistan.
FAU - Mumtaz, Shumaila
AU  - Mumtaz S
AD  - Applied Entomology and Medical Toxicology, Department of Zoology, Government 
      College University, Lahore, Pakistan.
FAU - Shakir, Hafiz Abdullah
AU  - Shakir HA
AD  - Department of Zoology, University of the Punjab, Lahore, Pakistan.
FAU - Ara, Chaman
AU  - Ara C
AD  - Department of Zoology, University of the Punjab, Lahore, Pakistan.
FAU - Ahmad, Farooq
AU  - Ahmad F
AD  - Department of Zoology, TheIslamia University of Bahawalpur, Bahawalpur, PK-63100, 
      Pakistan.
FAU - Tahir, Hafiz Muhammad
AU  - Tahir HM
AD  - Applied Entomology and Medical Toxicology, Department of Zoology, Government 
      College University, Lahore, Pakistan.
FAU - Faheem, Mehwish
AU  - Faheem M
AD  - Applied Entomology and Medical Toxicology, Department of Zoology, Government 
      College University, Lahore, Pakistan.
FAU - Irfan, Muhammad
AU  - Irfan M
AD  - Department of Biotechnology, University of Sargodha, Sargodha, Pakistan.
FAU - Masih, Azeem
AU  - Masih A
AD  - Department of Zoology, Government Murray College Sialkot, Sialkot, Pakistan.
FAU - Ulhaq, Mazhar
AU  - Ulhaq M
AD  - Department of Veterinary Biomedical Sciences, PMAS Arid Agriculture University, 
      Rawalpindi, PK-46300, Pakistan.
FAU - Andleeb, Saiqa
AU  - Andleeb S
AD  - Department of Zoology, The University of Azad Jammu and Kashmir, Muzaffarabad, 
      Pakistan.
LA  - eng
PT  - Journal Article
DEP - 20201030
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Chlorides)
RN  - 00BH33GNGH (Cadmium)
RN  - J6K4F9V3BA (Cadmium Chloride)
SB  - IM
MH  - Animals
MH  - *Cadmium/toxicity
MH  - Cadmium Chloride/toxicity
MH  - *Cadmium Poisoning
MH  - Chickens
MH  - Chlorides
MH  - Humans
OTO - NOTNLM
OT  - Bioaccumulation
OT  - Biochemical
OT  - Cadmium chloride
OT  - Hematological
OT  - Toxicity
EDAT- 2020/10/31 06:00
MHDA- 2021/07/08 06:00
CRDT- 2020/10/30 17:15
PHST- 2020/08/19 00:00 [received]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2020/10/31 06:00 [pubmed]
PHST- 2021/07/08 06:00 [medline]
PHST- 2020/10/30 17:15 [entrez]
AID - 10.1007/s12011-020-02453-9 [pii]
AID - 10.1007/s12011-020-02453-9 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2021 Sep;199(9):3457-3469. doi: 10.1007/s12011-020-02453-9. 
      Epub 2020 Oct 30.