PMID- 33126646
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201128
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 10
IP  - 11
DP  - 2020 Oct 28
TI  - Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated 
      Allergic Inflammation in a Murine Model of Asthma.
LID - 10.3390/life10110260 [doi]
LID - 260
AB  - Several air pollution components such as sulfur dioxide, ozone, nitrogen dioxide, 
      and diesel exhaust particulate matter (DEPM) have been linked to the development 
      of asthma. In this study, we investigated the therapeutic potential of three 
      lactic acid bacteria species, Lactobacillus plantarum GREEN CROSS Wellbeing 
      (GCWB)1001, Pediococcus acidilactici GCWB1085, and Lactobacillus rhamnosus 
      GCWB1156, in preventing DEPM-exacerbated asthma in mice. BALB/c mice were first 
      sensitized with ovalbumin (OVA) and were either challenged with OVA or DEPM 
      (DEPM-exacerbated asthma model) by intranasal instillation. All three strains 
      showed no hemolytic activity, suggesting a good safety profile. Oral 
      administration of lactic acid bacteria reduced OVA + DEPM-induced inflammatory 
      infiltration, goblet cell hyperplasia, airway remodeling, and the levels of 
      proinflammatory cytokines and chemokines in bronchoalveolar lavage fluid (BALF). 
      The probiotics also attenuated OVA + DEPM-induced immunoglobulin E (IgE) levels 
      in serum and in BALF, and significantly reduced caspase-3 activity, total 
      collagen level, and matrix metalloproteinase (MMP)-9 activity. In conclusion, 
      lactic acid bacteria such as L. plantarum GCWB1001, P. acidilactici GCWB1085, and 
      L. rhamnosus treatment in mice with asthma showed significant efficacy in 
      preventing lung inflammation exacerbated by DEPM administration.
FAU - Jin, Sun Woo
AU  - Jin SW
AD  - Department of Toxicology, College of Pharmacy, Chungnam National University, 
      Daejeon 34134, Korea.
FAU - Lee, Gi Ho
AU  - Lee GH
AD  - Department of Toxicology, College of Pharmacy, Chungnam National University, 
      Daejeon 34134, Korea.
FAU - Jang, Min Jung
AU  - Jang MJ
AD  - Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea.
FAU - Hong, Gyeong Eun
AU  - Hong GE
AD  - Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea.
FAU - Kim, Jae Young
AU  - Kim JY
AD  - Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea.
FAU - Park, Gi Deok
AU  - Park GD
AD  - Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea.
FAU - Jin, Hui
AU  - Jin H
AD  - Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea.
FAU - Kim, Hyun Su
AU  - Kim HS
AD  - Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea.
FAU - Choi, Chul Yung
AU  - Choi CY
AD  - Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research, 
      Naju 59338, Jeollanamdo, Korea.
FAU - Choi, Jae Ho
AU  - Choi JH
AD  - Subtropical/tropical Organism Gene Bank, Jeju National University, Jeju 63243, 
      Korea.
FAU - Lee, Su Gwon
AU  - Lee SG
AD  - Department of Pharmacokinetics, College of Pharmacy, Gachon University, Incheon 
      21936, Korea.
AD  - Department of Pharmaceutical Engineering, International University of Korea, 
      Jinju 52833, Korea.
FAU - Jeong, Hye Gwang
AU  - Jeong HG
AUID- ORCID: 0000-0002-8020-8914
AD  - Department of Toxicology, College of Pharmacy, Chungnam National University, 
      Daejeon 34134, Korea.
FAU - Hwang, Yong Pil
AU  - Hwang YP
AUID- ORCID: 0000-0002-0671-4181
AD  - Department of Pharmaceutical Engineering, International University of Korea, 
      Jinju 52833, Korea.
AD  - Fisheries Promotion Division, Mokpo City 58613, Jeollanamdo, Korea.
LA  - eng
GR  - 2019 research grant/GREEN CROSS WellBeing Co., Ltd./
PT  - Journal Article
DEP - 20201028
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC7692958
OTO - NOTNLM
OT  - DEPM
OT  - allergic airway inflammation
OT  - anti-inflammation
OT  - lactic acid bacteria
COIS- The authors declare no conflict of interest.
EDAT- 2020/11/01 06:00
MHDA- 2020/11/01 06:01
PMCR- 2020/11/01
CRDT- 2020/10/31 01:02
PHST- 2020/09/23 00:00 [received]
PHST- 2020/10/23 00:00 [revised]
PHST- 2020/10/26 00:00 [accepted]
PHST- 2020/10/31 01:02 [entrez]
PHST- 2020/11/01 06:00 [pubmed]
PHST- 2020/11/01 06:01 [medline]
PHST- 2020/11/01 00:00 [pmc-release]
AID - life10110260 [pii]
AID - life-10-00260 [pii]
AID - 10.3390/life10110260 [doi]
PST - epublish
SO  - Life (Basel). 2020 Oct 28;10(11):260. doi: 10.3390/life10110260.