PMID- 33127268
OWN - NLM
STAT- MEDLINE
DCOM- 20211223
LR  - 20221207
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 35
IP  - 1
DP  - 2021 Jan
TI  - Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of 
      type 2 diabetes mellitus and essential hypertension in a northern Chinese Han 
      population.
PG  - 107752
LID - S1056-8727(20)30533-X [pii]
LID - 10.1016/j.jdiacomp.2020.107752 [doi]
AB  - AIMS: Diabetes mellitus and hypertension are both complex diseases that are 
      caused by interactions among multiple genetic and physiological factors. To 
      investigate the association of common single-nucleotide polymorphisms (SNPs) of 
      SUCNR1, GRK4 and CAMK1D genes with the susceptibility of the two diseases in a 
      northern Chinese Han population. METHODS: 36 SNPs were genotyped in 2304 clinical 
      patients (1152 type 2 diabetes mellitus, 1152 essential hypertension) and 1152 
      health controls by Sequenom Mass-ARRAY RS1000. RESULTS: In this study, we found 
      that BMI, blood press, pulse pressure, FBG, total cholesterol and triglycerides 
      were associated with an increased risk of type 2 diabetes mellitus (T2DM) and 
      essential hypertension (EH). Three SNPs (SUCNR1: rs73168929; GRK4: rs1557213; 
      CAMK1D: rs17151584) significantly associated with the susceptibility of T2DM and 
      EH at the same time. Also, the susceptibility genotypes of 3 SNPs were 
      significantly correlated with liver and renal function parameters. CONCLUSION: To 
      the best of our knowledge, the present study is the first to report that three 
      SNPs (SUCNR1: rs73168929; GRK4: rs1557213; CAMK1D: rs17151584) contributed to the 
      risk of T2DM and EH in a northern Chinese Han population. These results provide a 
      favourable evidence for better understand of the underlying common mechanism of 
      these two diseases.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Du, Bingxin
AU  - Du B
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China.
FAU - Jia, Xinhui
AU  - Jia X
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China.
FAU - Tian, Wenqi
AU  - Tian W
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China.
FAU - Yan, Xueqin
AU  - Yan X
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China.
FAU - Wang, Ningning
AU  - Wang N
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China.
FAU - Cai, Defu
AU  - Cai D
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China.
FAU - Li, Xueyan
AU  - Li X
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China.
FAU - Zhang, Hao
AU  - Zhang H
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China.
FAU - Jin, Ming
AU  - Jin M
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China.
FAU - Wu, Nan
AU  - Wu N
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China.
FAU - Qiu, Changchun
AU  - Qiu C
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Institute of Medicine and Drug Research, Qiqihar Medical University, Qiqihar, 
      China. Electronic address: zhangqi@qmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201007
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (SUCNR1 protein, human)
RN  - EC 2.7.11.16 (G-Protein-Coupled Receptor Kinase 4)
RN  - EC 2.7.11.16 (GRK4 protein, human)
RN  - EC 2.7.11.17 (CAMK1D protein, human)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 1)
SB  - IM
MH  - Asian People/genetics
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 1
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Essential Hypertension
MH  - G-Protein-Coupled Receptor Kinase 4
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, G-Protein-Coupled
OTO - NOTNLM
OT  - CAMK1D
OT  - Diabetes mellitus
OT  - GRK4
OT  - Gene polymorphism
OT  - Hypertension
OT  - SUCNR1
EDAT- 2020/11/01 06:00
MHDA- 2021/12/24 06:00
CRDT- 2020/10/31 05:27
PHST- 2020/07/02 00:00 [received]
PHST- 2020/09/22 00:00 [revised]
PHST- 2020/09/25 00:00 [accepted]
PHST- 2020/11/01 06:00 [pubmed]
PHST- 2021/12/24 06:00 [medline]
PHST- 2020/10/31 05:27 [entrez]
AID - S1056-8727(20)30533-X [pii]
AID - 10.1016/j.jdiacomp.2020.107752 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2021 Jan;35(1):107752. doi: 
      10.1016/j.jdiacomp.2020.107752. Epub 2020 Oct 7.