PMID- 33128474
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20211101
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 48
IP  - 4
DP  - 2021 Apr
TI  - MYC gene amplification by fluorescence in situ hybridization and MYC protein 
      expression by immunohistochemistry in the diagnosis of cutaneous angiosarcoma: 
      Systematic review and appropriate use criteria.
PG  - 578-586
LID - 10.1111/cup.13912 [doi]
AB  - BACKGROUND: Secondary angiosarcoma (AS) most commonly follows breast cancer and 
      includes postirradiation AS (PRAS) and lymphedema-associated AS. The frequent 
      amplification of MYC (8q24.21) in secondary AS and the rising incidence of PRAS 
      and atypical vascular lesions (AVLs) have prompted interest in the diagnostic and 
      prognostic utility of MYC in AS. METHODS: Retrospective series with >/=2 cases of 
      cutaneous AS and describing the use of fluorescence in situ hybridization (FISH) 
      for MYC amplification or immunohistochemistry (IHC) for MYC overexpression were 
      included. RESULTS: Sixteen studies met inclusion criteria. Overall, 93% of cases 
      evaluated by FISH and IHC were concordant. The sensitivity of FISH in primary AS 
      was only 6.8%, and protein overexpression occurred without amplification in 
      sun-damaged skin. FISH and IHC were over 78% sensitive in secondary AS but 
      negative in over 98% of AVLs. MYC amplification and FLT4 coamplification were 
      associated with shorter overall survival in secondary AS. CONCLUSION: FISH for 
      MYC amplification and IHC for MYC overexpression are useful in distinguishing 
      PRAS from AVLs and may also have prognostic value in secondary AS. In contrast, 
      these methods have little diagnostic or prognostic value in primary AS and should 
      not be used to distinguish primary AS from benign vascular neoplasms.
CI  - (c) 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Motaparthi, Kiran
AU  - Motaparthi K
AUID- ORCID: 0000-0003-0562-0826
AD  - Department of Dermatology, University of Florida College of Medicine, 
      Gainesville, Florida, USA.
FAU - Lauer, Scott R
AU  - Lauer SR
AD  - Department of Pathology and Microbiology, University of Nebraska Medical Center, 
      Omaha, Nebraska, USA.
FAU - Patel, Rajiv M
AU  - Patel RM
AUID- ORCID: 0000-0002-1521-4947
AD  - Michigan Medicine Department of Pathology, University of Michigan, Ann Arbor, 
      Michigan, USA.
AD  - Michigan Medicine Department of Dermatology, University of Michigan, Ann Arbor, 
      Michigan, USA.
FAU - Vidal, Claudia I
AU  - Vidal CI
AUID- ORCID: 0000-0003-2672-4974
AD  - Dermatology Center of Southern Indiana, Bloomington, Indiana, USA.
FAU - Linos, Konstantinos
AU  - Linos K
AUID- ORCID: 0000-0001-9462-652X
AD  - Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical 
      Center, Lebanon, NH and Geisel School of Medicine, Hanover, New Hampshire, USA.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20201116
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - Radiation induced angiosarcoma of the breast
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/diagnosis/metabolism/pathology/radiotherapy
MH  - Female
MH  - Gene Amplification/*genetics
MH  - Hemangiosarcoma/diagnosis/*genetics/metabolism/mortality/pathology
MH  - Humans
MH  - Immunohistochemistry/*methods
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Lymphedema/complications/metabolism/pathology
MH  - Neoplasms, Radiation-Induced/diagnosis/metabolism/pathology
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Skin Neoplasms/genetics/pathology
OTO - NOTNLM
OT  - MYC
OT  - angiosarcoma
OT  - appropriate use criteria
OT  - atypical vascular lesions
OT  - fluorescence in situ hybridization
OT  - immunohistochemistry
EDAT- 2020/11/01 06:00
MHDA- 2021/11/03 06:00
CRDT- 2020/10/31 12:05
PHST- 2020/10/12 00:00 [revised]
PHST- 2020/08/23 00:00 [received]
PHST- 2020/10/25 00:00 [accepted]
PHST- 2020/11/01 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2020/10/31 12:05 [entrez]
AID - 10.1111/cup.13912 [doi]
PST - ppublish
SO  - J Cutan Pathol. 2021 Apr;48(4):578-586. doi: 10.1111/cup.13912. Epub 2020 Nov 16.