PMID- 33129324
OWN - NLM
STAT- MEDLINE
DCOM- 20210113
LR  - 20240324
IS  - 1465-542X (Electronic)
IS  - 1465-5411 (Print)
IS  - 1465-5411 (Linking)
VI  - 22
IP  - 1
DP  - 2020 Oct 31
TI  - Use of nonsteroidal anti-inflammatory drugs and breast cancer risk in a 
      prospective cohort of postmenopausal women.
PG  - 118
LID - 10.1186/s13058-020-01343-1 [doi]
LID - 118
AB  - BACKGROUND: Although anti-inflammatory agents could theoretically have anticancer 
      properties, results from cohort studies on nonsteroidal anti-inflammatory drugs 
      (NSAIDs) and breast cancer (BC) risk are inconsistent. METHODS: We investigated 
      the association between NSAID use and BC incidence in the French E3N prospective 
      cohort, which includes 98,995 women born between 1925 and 1950 and insured by a 
      health insurance plan that covers mostly teachers. Self-reported information on 
      lifestyle and medical history has been collected biennially by questionnaires and 
      matched with data from a drug reimbursement database covering the period 
      2004-2014. Women who self-reported current NSAID use in the 2000 or 2002 
      questionnaires or with at least two reimbursements in any previous 3-month period 
      were defined as exposed to NSAIDs. Multivariable Cox regression models were used 
      to estimate hazard ratios (HRs) for the association of NSAID use with BC risk. 
      RESULTS: In the current analysis, 62,512 postmenopausal women were followed 
      between 2004 and 2014 (9 years on average, starting at a mean age of 63 years; 
      2864 incident BC). In multivariable models, there was no statistically 
      significant association between NSAID use and BC risk [HR = 1.00 (0.92-1.08), 
      compared with non-exposed women]. The NSAID-BC associations did not differ by 
      NSAID types, BC subtypes, risk factors, and comorbidities, nor by duration and 
      dose of use. However, a statistically significant interaction was observed by 
      proton pump inhibitor (PPI) drug use (P(interaction) = 0.01) whereby a decreased 
      risk of BC with NSAID use was only observed among women who also used PPI before. 
      CONCLUSION: Only women who used NSAIDs after having used PPI had a lower risk of 
      BC. This result is novel and requires replication in other studies.
FAU - Cairat, Manon
AU  - Cairat M
AD  - Nutrition and Metabolism Section, International Agency for Research on Cancer, 
      Lyon, France.
FAU - Al Rahmoun, Marie
AU  - Al Rahmoun M
AD  - Centre de recherche en Epidemiologie et Sante des Populations (CESP), equipe 
      "Exposome, Heredite, Cancer et Sante", Faculte de Medecine Universite 
      Paris-Saclay, UVSQ, Inserm U1018, Villejuif, France.
AD  - Gustave Roussy, Villejuif, France.
FAU - Gunter, Marc J
AU  - Gunter MJ
AD  - Nutrition and Metabolism Section, International Agency for Research on Cancer, 
      Lyon, France.
FAU - Severi, Gianluca
AU  - Severi G
AD  - Centre de recherche en Epidemiologie et Sante des Populations (CESP), equipe 
      "Exposome, Heredite, Cancer et Sante", Faculte de Medecine Universite 
      Paris-Saclay, UVSQ, Inserm U1018, Villejuif, France.
AD  - Gustave Roussy, Villejuif, France.
AD  - Department of Statistics, Computer Science and Applications "G. Parenti" (DISIA), 
      University of Florence, Florence, Italy.
FAU - Dossus, Laure
AU  - Dossus L
AD  - Nutrition and Metabolism Section, International Agency for Research on Cancer, 
      Lyon, France.
FAU - Fournier, Agnes
AU  - Fournier A
AUID- ORCID: 0000-0001-8380-3439
AD  - Centre de recherche en Epidemiologie et Sante des Populations (CESP), equipe 
      "Exposome, Heredite, Cancer et Sante", Faculte de Medecine Universite 
      Paris-Saclay, UVSQ, Inserm U1018, Villejuif, France. 
      Agnes.FOURNIER@gustaveroussy.fr.
AD  - Gustave Roussy, Villejuif, France. Agnes.FOURNIER@gustaveroussy.fr.
LA  - eng
GR  - 001/WHO_/World Health Organization/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201031
PL  - England
TA  - Breast Cancer Res
JT  - Breast cancer research : BCR
JID - 100927353
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Proton Pump Inhibitors)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Aged
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage
MH  - Aspirin/*administration & dosage
MH  - Breast Neoplasms/*drug therapy/epidemiology/pathology
MH  - Cohort Studies
MH  - Comorbidity
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Incidence
MH  - Middle Aged
MH  - *Postmenopause
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Risk Factors
MH  - Surveys and Questionnaires/*statistics & numerical data
PMC - PMC7603705
OTO - NOTNLM
OT  - Breast cancer
OT  - Nonsteroidal anti-inflammatory drugs
OT  - Postmenopausal women
OT  - Proton pump inhibitors
COIS- The authors declare that they have no competing interests.
EDAT- 2020/11/02 06:00
MHDA- 2021/01/14 06:00
PMCR- 2020/10/31
CRDT- 2020/11/01 20:23
PHST- 2020/06/11 00:00 [received]
PHST- 2020/09/16 00:00 [accepted]
PHST- 2020/11/01 20:23 [entrez]
PHST- 2020/11/02 06:00 [pubmed]
PHST- 2021/01/14 06:00 [medline]
PHST- 2020/10/31 00:00 [pmc-release]
AID - 10.1186/s13058-020-01343-1 [pii]
AID - 1343 [pii]
AID - 10.1186/s13058-020-01343-1 [doi]
PST - epublish
SO  - Breast Cancer Res. 2020 Oct 31;22(1):118. doi: 10.1186/s13058-020-01343-1.