PMID- 33129427
OWN - NLM
STAT- MEDLINE
DCOM- 20201123
LR  - 20201123
IS  - 1535-7732 (Electronic)
IS  - 1051-0443 (Linking)
VI  - 31
IP  - 11
DP  - 2020 Nov
TI  - Radiofrequency Ablation for the Palliative Treatment of Bone Metastases: Outcomes 
      from the Multicenter OsteoCool Tumor Ablation Post-Market Study (OPuS One Study) 
      in 100 Patients.
PG  - 1745-1752
LID - S1051-0443(20)30591-1 [pii]
LID - 10.1016/j.jvir.2020.07.014 [doi]
AB  - PURPOSE: To evaluate the effectiveness of radiofrequency (RF) ablation as 
      measured by change in worst pain score from baseline to 3 mo after RF ablation 
      for the palliative treatment of painful bone metastases. MATERIALS AND METHODS: 
      One hundred patients (mean age, 64.6 y) underwent RF ablation for metastatic bone 
      disease and were followed up to 6 mo. Subjects' pain and quality of life were 
      measured before RF ablation and postoperatively by using the Brief Pain Index and 
      European Quality of Life questionnaires. Opioid agent use and device-, 
      procedure-, and/or therapy-related adverse events (AEs) were collected. RESULTS: 
      Eighty-seven patients were treated for tumors involving the thoracolumbar spine 
      and 13 for tumors located in the pelvis and/or sacrum. All ablations were 
      technically successful, and 97% were followed by cementoplasty. Mean worst pain 
      score decreased from 8.2 +/- 1.7 at baseline to 3.5 +/- 3.2 at 6 mo (n = 22; P < 
      0.0001 for all visits). Subjects experienced significant improvement for all 
      visits in average pain (P < .0001), pain interference (P < .0001), and quality of 
      life (P < .003). Four AEs were reported, of which 2 resulted in hospitalization 
      for pneumonia and respiratory failure. All 30 deaths reported during the study 
      were attributed to the underlying malignancy and not related to the study 
      procedure. CONCLUSIONS: Results from this study show rapid (within 3 d) and 
      statistically significant pain improvement with sustained long-term relief 
      through 6 mo in patients treated with RF ablation for metastatic bone disease.
CI  - Copyright (c) 2020 SIR. Published by Elsevier Inc. All rights reserved.
FAU - Levy, Jason
AU  - Levy J
AD  - Department of Interventional Radiology, Northside Hospital, Atlanta, Georgia.
FAU - Hopkins, Thomas
AU  - Hopkins T
AD  - Department of Anesthesiology, Duke University Medical Center, Durham, North 
      Carolina.
FAU - Morris, Jonathan
AU  - Morris J
AD  - Department of Radiology, Mayo Clinic, Rochester, Minnesota.
FAU - Tran, Nam D
AU  - Tran ND
AD  - Department of Neurosurgery, Moffitt Cancer Center, Tampa, Florida.
FAU - David, Elizabeth
AU  - David E
AD  - Department of Interventional Radiology, Sunnybrook Health Sciences Centre, 
      Toronto, Ontario, Canada.
FAU - Massari, Francesco
AU  - Massari F
AD  - Department of Neurointerventional Radiology, University of Massachusetts Memorial 
      Medical Center, Worcester, Massachusetts.
FAU - Farid, Hamed
AU  - Farid H
AD  - Department of Neurointerventional Radiology, St. Jude Medical Center, Fullerton, 
      California.
FAU - Vogel, Alexander
AU  - Vogel A
AD  - Department of Interventional Radiology, Renown Regional Medical Center, Reno, 
      Nevada.
FAU - O'Connell, William G
AU  - O'Connell WG
AD  - Department of Interventional Radiology, Emory University School of Medicine, 
      Atlanta, Georgia.
FAU - Sunenshine, Peter
AU  - Sunenshine P
AD  - Department of Radiology, Banner-University Medical Center, Phoenix, Arizona.
FAU - Dixon, Robert
AU  - Dixon R
AD  - Department of Interventional Radiology, University of North Carolina at Chapel 
      Hill, Chapel Hill, North Carolina.
FAU - Gangi, Afshin
AU  - Gangi A
AD  - Department of Interventional Radiology, Hopitaux Universitaires de 
      Strasbourg-Nouvel Hopital Civil, Strasbourg, France.
FAU - von der Hoh, Nicolas
AU  - von der Hoh N
AD  - Department of Orthopedic, Trauma and Plastic Surgery, Universitatsklinikum 
      Leipzig AoR, Leipzig, Germany.
FAU - Bagla, Sandeep
AU  - Bagla S
AD  - Department of Interventional Radiology, Prostate Centers USA, LLC, Vascular 
      Interventional Partners NOVA, 2755 Hartland Road, Falls Church, VA 22043. 
      Electronic address: Sandeep.bagla@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - J Vasc Interv Radiol
JT  - Journal of vascular and interventional radiology : JVIR
JID - 9203369
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Neoplasms/complications/mortality/secondary/*surgery
MH  - Cementoplasty
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain/diagnosis/etiology/mortality/*prevention & control
MH  - Pain Measurement
MH  - *Palliative Care
MH  - Prospective Studies
MH  - Quality of Life
MH  - *Radiofrequency Ablation/adverse effects/mortality
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2020/11/02 06:00
MHDA- 2020/11/24 06:00
CRDT- 2020/11/01 20:24
PHST- 2020/02/07 00:00 [received]
PHST- 2020/06/16 00:00 [revised]
PHST- 2020/07/14 00:00 [accepted]
PHST- 2020/11/01 20:24 [entrez]
PHST- 2020/11/02 06:00 [pubmed]
PHST- 2020/11/24 06:00 [medline]
AID - S1051-0443(20)30591-1 [pii]
AID - 10.1016/j.jvir.2020.07.014 [doi]
PST - ppublish
SO  - J Vasc Interv Radiol. 2020 Nov;31(11):1745-1752. doi: 10.1016/j.jvir.2020.07.014.