PMID- 33130054
OWN - NLM
STAT- MEDLINE
DCOM- 20210916
LR  - 20210916
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 70
DP  - 2021 Feb
TI  - Overall performance of Bovine Corneal Opacity and Permeability (BCOP) Laser 
      Light-Based Opacitometer (LLBO) test method with regard to solid and liquid 
      chemicals testing.
PG  - 105044
LID - S0887-2333(20)30596-8 [pii]
LID - 10.1016/j.tiv.2020.105044 [doi]
AB  - A prospective study of the Bovine Corneal Opacity and Permeability (BCOP) Laser 
      Light-Based Opacitometer (LLBO) test method was conducted to evaluate its 
      usefulness to identify chemicals as inducing serious eye damage (Cat. 1) or 
      chemicals not requiring classification for eye irritation (No Cat.) applying 
      United Nations Globally Harmonized System of Classification and Labelling of 
      Chemicals (UN GHS). The aim was to demonstrate the reproducibility of the BCOP 
      LLBO protocol for liquids and solids and define its predictive capacity. Briefly, 
      145 chemicals were simultaneously tested with BCOP LLBO and OP-KIT (OECD TG 437), 
      one to two times in one laboratory. When used to identify Cat. 1, the BCOP LLBO 
      has a false negative rate (FNR) of 24.1% (N = 56) compared to 34.8% (N = 56) for 
      the BCOP OP-KIT, with a comparable false positive rate (FPR, N = 89) of 18.5% and 
      20.8%, respectively. When used to identify chemicals not requiring classification 
      (No Cat.) the BCOP LLBO and BCOP OP-KIT had a FNR (N = 104) of 6.2% and 7.2% and 
      a FPR (N = 41) of 45.1% and 42.7%, respectively. The OP-KIT and LLBO devices are 
      interchangeable at no cost to data quality and reliability. The OP-KIT and LLBO 
      devices are interchangeable at no cost to data quality and reliability. The 
      performance of the LLBO is at least as good as the OP-KIT, both methods can be 
      used to identify UN GHS Cat. 1 and UN GHS No Cat. chemicals.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Adriaens, E
AU  - Adriaens E
AD  - Adriaens Consulting, Aalter, Belgium. Electronic address: 
      adriaens.consulting@telenet.be.
FAU - Verstraelen, S
AU  - Verstraelen S
AD  - VITO NV (Flemish Institute for Technological Research), Mol, Belgium.
FAU - Desprez, B
AU  - Desprez B
AD  - Cosmetics Europe - The Personal Care Association, Brussels, Belgium; ANSES 
      (French Agency for Food, Environment and Occupational Health & Safety), Maison 
      Alfort, France.
FAU - Alepee, N
AU  - Alepee N
AD  - L'Oreal Research & Innovation, Aulnay Sous Bois, France.
FAU - Abo, T
AU  - Abo T
AD  - Kao Corporation, Safety Science Research, Kanagawa, Japan.
FAU - Bagley, D
AU  - Bagley D
AD  - Colgate-Palmolive Co., Piscataway, NJ, USA.
FAU - Hibatallah, J
AU  - Hibatallah J
AD  - Chanel Parfums Beaute, Neuilly sur Seine, France.
FAU - Mewes, K R
AU  - Mewes KR
AD  - Henkel AG&Co. KGaA, Dusseldorf, Germany.
FAU - Pfannenbecker, U
AU  - Pfannenbecker U
AD  - Beiersdorf AG, Hamburg, Germany.
FAU - Van Rompay, A R
AU  - Van Rompay AR
AD  - VITO NV (Flemish Institute for Technological Research), Mol, Belgium; Penman 
      Consulting BVBA, Brussels, Belgium.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20201031
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with 
      BIBRA
JID - 8712158
RN  - 0 (Irritants)
SB  - IM
MH  - Animal Testing Alternatives
MH  - Animals
MH  - Cattle
MH  - Corneal Opacity/*chemically induced
MH  - Eye/drug effects/metabolism
MH  - Irritants/*toxicity
MH  - Lasers
MH  - Light
MH  - Permeability/drug effects
MH  - Toxicity Tests/*methods
EDAT- 2020/11/02 06:00
MHDA- 2021/09/18 06:00
CRDT- 2020/11/01 20:30
PHST- 2020/07/28 00:00 [received]
PHST- 2020/10/17 00:00 [revised]
PHST- 2020/10/27 00:00 [accepted]
PHST- 2020/11/02 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2020/11/01 20:30 [entrez]
AID - S0887-2333(20)30596-8 [pii]
AID - 10.1016/j.tiv.2020.105044 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2021 Feb;70:105044. doi: 10.1016/j.tiv.2020.105044. Epub 2020 
      Oct 31.