PMID- 33130208
OWN - NLM
STAT- MEDLINE
DCOM- 20210304
LR  - 20210304
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 102
DP  - 2021 Jan
TI  - High yield from repeated testing for tuberculosis among high-risk citizens in 
      Denmark.
PG  - 352-356
LID - S1201-9712(20)32281-5 [pii]
LID - 10.1016/j.ijid.2020.10.076 [doi]
AB  - BACKGROUND: Screening for TB (tuberculosis) among socially marginalized citizens 
      has been implemented in many urban areas in countries with a low incidence of TB, 
      including Denmark. This study aims to describe the findings of the screening 
      programs for TB and latent tuberculosis (LTBI) used in the western part of 
      Denmark in the period 2014-2019. METHODS: Data was collected retrospectively on 
      test results from interferon-gamma release assays (IGRA), spot sputum tests and 
      chest X-rays performed as part of TB and LTBI screening among 1024 socially 
      marginalized citizens in urban areas of western Denmark in 2014-2019. RESULTS: 
      The overall TB incidence was 2148/100.000 and number needed to screen to find one 
      TB case was 39. The incidence of LTBI in the group screened using IGRA was 
      17.500/100.000. TB incidence when using spot sputum test was 2.5, while TB 
      incidence when using IGRA as the primary screening test was 2.7. In total, 38.9% 
      of TB diagnoses were obtained after the second or third round of screening. 
      CONCLUSION: We demonstrated a high incidence of TB and LTBI among socially 
      marginalized citizens in Denmark. Screening with spot sputum testing and IGRA 
      generated comparable results in diagnosing TB in this setting.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Staerke, Nina Breinholt
AU  - Staerke NB
AD  - Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensens 
      Boulevard 99, 8200 Aarhus N, Denmark; Department of Clinical Medicine, Aarhus 
      University, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark. Electronic 
      address: ninase@rm.dk.
FAU - Smidt-Hansen, Torben
AU  - Smidt-Hansen T
AD  - Department of Pulmonary Medicine, Aarhus University Hospital, Palle Juul-Jensens 
      Boulevard 99, 8200 Aarhus N, Denmark.
FAU - Oldenborg, Leni
AU  - Oldenborg L
AD  - Department of Pulmonary Medicine, Aarhus University Hospital, Palle Juul-Jensens 
      Boulevard 99, 8200 Aarhus N, Denmark.
FAU - Jensen, Torben Tranborg
AU  - Jensen TT
AD  - Department of Pulmonary Medicine, Sydvestjysk Sygehus, Finsensgade 35, 6700 
      Esbjerg, Denmark.
FAU - Weinreich, Ulla Moller
AU  - Weinreich UM
AD  - Department of Pulmonary Medicine, Aalborg University Hospital, Hobrovej 18-22, 
      9000 Aalborg, Denmark.
FAU - Shakar, Shakil
AU  - Shakar S
AD  - Department of Pulmonary Medicine, Aalborg University Hospital, Hobrovej 18-22, 
      9000 Aalborg, Denmark; Department of Internal Medicine, North Denmark Regional 
      Hospital, Bispensgade 37, 9800 Hjoerring, Denmark.
FAU - Wejse, Christian
AU  - Wejse C
AD  - Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensens 
      Boulevard 99, 8200 Aarhus N, Denmark; GloHAU, Center for Global Health, 
      Department of Public Health, Aarhus University, Bartholins Alle 2, 8000 Aarhus C, 
      Denmark.
FAU - Hilberg, Ole
AU  - Hilberg O
AD  - Department of Internal Medicine, Sygehus Lillebaelt, Beriderbakken 4, 7100 Vejle, 
      Denmark; Department of Regional Health Research, University of Southern Denmark, 
      Campusvej 55, 5230 Odense M, Denmark.
FAU - Floe, Andreas
AU  - Floe A
AD  - Department of Pulmonary Medicine, Aarhus University Hospital, Palle Juul-Jensens 
      Boulevard 99, 8200 Aarhus N, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20201031
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Denmark/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Interferon-gamma Release Tests/methods
MH  - Latent Tuberculosis/*diagnosis/diagnostic imaging/epidemiology
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Tuberculin Test
MH  - Tuberculosis/*diagnosis/epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Active case finding
OT  - Homeless
OT  - Latent tuberculosis infection
OT  - Screening
OT  - Socially marginalized
EDAT- 2020/11/02 06:00
MHDA- 2021/03/05 06:00
CRDT- 2020/11/01 20:31
PHST- 2020/09/21 00:00 [received]
PHST- 2020/10/20 00:00 [revised]
PHST- 2020/10/23 00:00 [accepted]
PHST- 2020/11/02 06:00 [pubmed]
PHST- 2021/03/05 06:00 [medline]
PHST- 2020/11/01 20:31 [entrez]
AID - S1201-9712(20)32281-5 [pii]
AID - 10.1016/j.ijid.2020.10.076 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2021 Jan;102:352-356. doi: 10.1016/j.ijid.2020.10.076. Epub 
      2020 Oct 31.