PMID- 33130513 OWN - NLM STAT- MEDLINE DCOM- 20210331 LR - 20210331 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 294 DP - 2020 Dec TI - Negative symptom configuration within and outside schizophrenia spectrum disorders: results from the "Parma Early Psychosis" program. PG - 113519 LID - S0165-1781(20)33180-2 [pii] LID - 10.1016/j.psychres.2020.113519 [doi] AB - The identification of discrete dimensions underlining negative symptoms in First Episode Psychosis (FEP) may be useful in the treatment strategy for such severe symptomatology. Aim of this research was to investigate the negative symptom configuration in FEP patients and to compare the emerging factor solutions between individuals with and without Schizophrenia Spectrum Disorders (non-SSD vs SSD). Two-hundred-seventy-four participants (144 non-SSD and 130 SSD), aged 13-35 years, completed the Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning (GAF). Confirmatory and exploratory factor analyses were then performed to examine PANSS negative symptom configuration in both SSD and non-SSD samples. In SSD, a 3-factor model solution (i.e. "Experiential Deficits", "Volition/Empathy Deficits" and "Motor/Affective Expression Deficits" domains) was identified. A different 2-factor configuration (with "Social/Communicative Withdrawal" and "Motor/Affective/Motivational Deficits" dimensions) was more appropriate in non-SSD. In conclusion, our results show differences in negative symptom factor models between non-SSD and SSD. Thus, a different specificity and significance of negative symptom solutions in FEP populations with diagnoses other than schizophrenia (compared to those with SSD) must be realistically considered. CI - Copyright (c) 2020. Published by Elsevier B.V. FAU - Pelizza, Lorenzo AU - Pelizza L AD - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Largo Palli n. 1/A, 43100 Parma, Italy; Department of Mental Health and Pathological Addiction, Azienda USL-IRCCS di Reggio Emilia, Via Amendola n.2, 43100 Reggio Emilia, Italy. Electronic address: lorpelizza@ausl.pr.it. FAU - Maestri, Davide AU - Maestri D AD - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Largo Palli n. 1/A, 43100 Parma, Italy; Department of Mental Health and Pathological Addiction, Azienda USL-IRCCS di Reggio Emilia, Via Amendola n.2, 43100 Reggio Emilia, Italy. FAU - Leuci, Emanuela AU - Leuci E AD - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Largo Palli n. 1/A, 43100 Parma, Italy; Department of Mental Health and Pathological Addiction, Azienda USL-IRCCS di Reggio Emilia, Via Amendola n.2, 43100 Reggio Emilia, Italy. FAU - Quattrone, Emanuela AU - Quattrone E AD - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Largo Palli n. 1/A, 43100 Parma, Italy; Department of Mental Health and Pathological Addiction, Azienda USL-IRCCS di Reggio Emilia, Via Amendola n.2, 43100 Reggio Emilia, Italy. FAU - Azzali, Silvia AU - Azzali S AD - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Largo Palli n. 1/A, 43100 Parma, Italy; Department of Mental Health and Pathological Addiction, Azienda USL-IRCCS di Reggio Emilia, Via Amendola n.2, 43100 Reggio Emilia, Italy. FAU - Paulillo, Giuseppina AU - Paulillo G AD - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Largo Palli n. 1/A, 43100 Parma, Italy; Department of Mental Health and Pathological Addiction, Azienda USL-IRCCS di Reggio Emilia, Via Amendola n.2, 43100 Reggio Emilia, Italy. FAU - Pellegrini, Pietro AU - Pellegrini P AD - Department of Mental Health and Pathological Addiction, Azienda USL di Parma, Largo Palli n. 1/A, 43100 Parma, Italy; Department of Mental Health and Pathological Addiction, Azienda USL-IRCCS di Reggio Emilia, Via Amendola n.2, 43100 Reggio Emilia, Italy. LA - eng PT - Journal Article DEP - 20201026 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM MH - Adolescent MH - Adult MH - Child MH - Factor Analysis, Statistical MH - Female MH - Humans MH - Male MH - *Psychiatric Status Rating Scales MH - Psychotic Disorders/*diagnosis/epidemiology/*psychology MH - Schizophrenia/*diagnosis/epidemiology MH - *Schizophrenic Psychology MH - Young Adult OTO - NOTNLM OT - Early Psychosis OT - Factor Analysis OT - First Episode Psychosis OT - First Episode Schizophrenia OT - Negative Symptoms EDAT- 2020/11/02 06:00 MHDA- 2021/04/01 06:00 CRDT- 2020/11/01 20:39 PHST- 2020/06/20 00:00 [received] PHST- 2020/10/19 00:00 [accepted] PHST- 2020/11/02 06:00 [pubmed] PHST- 2021/04/01 06:00 [medline] PHST- 2020/11/01 20:39 [entrez] AID - S0165-1781(20)33180-2 [pii] AID - 10.1016/j.psychres.2020.113519 [doi] PST - ppublish SO - Psychiatry Res. 2020 Dec;294:113519. doi: 10.1016/j.psychres.2020.113519. Epub 2020 Oct 26.