PMID- 33131163
OWN - NLM
STAT- MEDLINE
DCOM- 20220317
LR  - 20220317
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 52
IP  - 1
DP  - 2022 Jan
TI  - Effect of donor age on adult unrelated donor haemopoietic cell transplant 
      outcome: the Australian experience.
PG  - 57-62
LID - 10.1111/imj.15128 [doi]
AB  - BACKGROUND: Results have been varied regarding the effect of donor age on the 
      outcome of unrelated donor haemopoietic cell transplantation (HCT). AIMS: To 
      determine the influence of donor age on adult unrelated donor HCT outcome in 
      Australia. METHODS: Patients were included in the study if they were aged 16 
      years or above and underwent first allogeneic unrelated donor HCT in Australia 
      for the indications of acute lymphoblastic leukaemia (ALL), acute myelogenous 
      leukaemia (AML), chronic myelogenous leukaemia (CML) or myelodysplastic syndromes 
      (MDS) between the years of 2001 and 2014 inclusive. The main outcome measure was 
      overall survival (OS), which was tested against independent variables using 
      univariate Kaplan-Meier methods and multivariate Cox regression. RESULTS: A total 
      of 1158 unrelated donor HCT were represented in the data. Cumulative incidences 
      of engraftment, transplant related mortality (TRM), acute graft-versus-host 
      disease (GvHD), chronic GvHD and relapse were not significantly affected by donor 
      age. OS probability at 5 years post-transplant was 48.3%. In multivariate 
      analysis of OS, year of transplant 2001-2007, recipient age 40 years or greater, 
      poor risk disease, human leukocyte antigen (HLA) match less than 6/6 and poor 
      performance status at transplant (Karnofsky scale) were independently significant 
      adverse OS risk factors. Donor age was not a significant risk factor for OS in 
      univariate or multivariate analysis. CONCLUSIONS: The conclusion from this study 
      was that donor age (up to 59 years) did not influence post-transplant outcome 
      among adult unrelated donor HCT performed in Australia for haematologic 
      malignancies.
CI  - (c) 2020 Royal Australasian College of Physicians.
FAU - Nivison-Smith, Ian
AU  - Nivison-Smith I
AUID- ORCID: 0000-0002-1160-8439
AD  - Australasian Bone Marrow Transplant Recipient Registry (ABMTRR), Sydney, New 
      South Wales, Australia.
FAU - Bajel, Ashish
AU  - Bajel A
AD  - Integrated Haematology Service, Royal Melbourne Hospital, Melbourne, Victoria, 
      Australia.
FAU - Dodds, Anthony J
AU  - Dodds AJ
AD  - Consultant Haematologist and Medical Director, SydPath, St Vincent's Hospital, 
      Sydney, New South Wales, Australia.
FAU - Gottlieb, David
AU  - Gottlieb D
AD  - Department of Cell Therapies, Westmead Hospital, Sydney, New South Wales, 
      Australia.
FAU - Hamad, Nada
AU  - Hamad N
AUID- ORCID: 0000-0001-7929-1450
AD  - Department of Haematology and SCT, St Vincent's Hospital, Sydney, New South 
      Wales, Australia.
FAU - Kennedy, Glen
AU  - Kennedy G
AD  - Director BMT Unit, Division of Cancer Care Services, Royal Brisbane and Women's 
      Hospital, Brisbane, Queensland, Australia.
FAU - Kerridge, Ian
AU  - Kerridge I
AD  - Haematology Department, Royal North Shore Hospital, Sydney, New South Wales, 
      Australia.
FAU - Ma, David D F
AU  - Ma DDF
AD  - Department of Haematology and SCT, St Vincent's Hospital, Sydney, New South 
      Wales, Australia.
FAU - Milliken, Samuel
AU  - Milliken S
AD  - Department of Haematology and SCT, St Vincent's Hospital, Sydney, New South 
      Wales, Australia.
FAU - Moore, John
AU  - Moore J
AD  - Department of Haematology and SCT, St Vincent's Hospital, Sydney, New South 
      Wales, Australia.
FAU - Purtill, Duncan
AU  - Purtill D
AD  - Transplant Physician, Department of Haematology, Fiona Stanley Hospital, Perth, 
      Western Australia, Australia.
FAU - Szer, Jeff
AU  - Szer J
AUID- ORCID: 0000-0001-6783-2301
AD  - Integrated Haematology Service, Royal Melbourne Hospital, Melbourne, Victoria, 
      Australia.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Australia/epidemiology
MH  - *Hematopoietic Stem Cell Transplantation/methods
MH  - Humans
MH  - Neoplasm Recurrence, Local
MH  - Treatment Outcome
MH  - *Unrelated Donors
OTO - NOTNLM
OT  - Australia
OT  - New Zealand
OT  - cell
OT  - haemopoietic
OT  - transplantation
OT  - unrelated donor age
EDAT- 2020/11/02 06:00
MHDA- 2022/03/18 06:00
CRDT- 2020/11/01 20:44
PHST- 2020/08/11 00:00 [revised]
PHST- 2020/03/22 00:00 [received]
PHST- 2020/10/19 00:00 [accepted]
PHST- 2020/11/02 06:00 [pubmed]
PHST- 2022/03/18 06:00 [medline]
PHST- 2020/11/01 20:44 [entrez]
AID - 10.1111/imj.15128 [doi]
PST - ppublish
SO  - Intern Med J. 2022 Jan;52(1):57-62. doi: 10.1111/imj.15128.