PMID- 33132836 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230322 IS - 1662-4548 (Print) IS - 1662-453X (Electronic) IS - 1662-453X (Linking) VI - 14 DP - 2020 TI - Optical Coherence Tomography Angiography Reveals Distinct Retinal Structural and Microvascular Abnormalities in Cerebrovascular Disease. PG - 588515 LID - 10.3389/fnins.2020.588515 [doi] LID - 588515 AB - Cerebrovascular disease (CeVD) is one of the leading global causes of death and severe disability. To date, retinal microangiopathy has become a reflection of cerebral microangiopathy, mirroring the vascular pathological modifications in vivo. To evaluate the retinal structure and microvasculature in patients with CeVD, we conducted a cross-sectional study in Zhongshan Ophthalmic Center and Department of Neurology of Third Affiliated Hospital, Sun Yat-sen University using optical coherence tomography angiography (OCTA). CeVD patients (n = 121; 238 eyes) and healthy controls (n = 44; 57 eyes) were included in the analysis. The CeVD group showed significant thinning of the peripapillary retinal nerve fiber layer (pRNFL) thickness in the temporal and nasal quadrants, and thinning of the macular ganglion cell-inner plexiform layer (GC-IPL) in the inferior quadrant, while macular microvasculature reduction was prominent in all nine quadrants. There were significant correlations between OCTA parameters, visual acuity, and transcranial doppler parameters in the CeVD group. The specific structural parameters combining microvasculature indices showed the best diagnostic accuracies (AUC = 0.918) to discriminate CeVD group from healthy controls. To conclude, we proved that OCTA reveals specific patterns of retinal structural changes and extensive macular microvascular changes in CeVD. Additionally, these retinal abnormalities could prove useful disease biomarkers in the management of individuals at high risk of debilitating complications from a cerebrovascular event. CI - Copyright (c) 2020 Zhang, Xiao, Liu, Liu, Zhao, Wang, Wang, Wang, Zhu, Chen, Wu, Lin, Qiu, Yu-Wai-Man, Lu and Lin. FAU - Zhang, Xiayin AU - Zhang X AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. FAU - Xiao, Hui AU - Xiao H AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. FAU - Liu, Chunxin AU - Liu C AD - Department of Neurology, Psychological and Neurological Diseases Research Centre, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Liu, Sanxin AU - Liu S AD - Department of Neurology, Psychological and Neurological Diseases Research Centre, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Zhao, Lanqin AU - Zhao L AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. FAU - Wang, Ruixin AU - Wang R AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. FAU - Wang, Jinghui AU - Wang J AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. FAU - Wang, Ting AU - Wang T AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. FAU - Zhu, Yi AU - Zhu Y AD - Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, United States. FAU - Chen, Chuan AU - Chen C AD - Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States. FAU - Wu, Xiaohang AU - Wu X AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. FAU - Lin, Duoru AU - Lin D AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. FAU - Qiu, Wei AU - Qiu W AD - Department of Neurology, Psychological and Neurological Diseases Research Centre, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Yu-Wai-Man, Patrick AU - Yu-Wai-Man P AD - Cambridge Centre for Brain Repair and MRC Mitochondrial Biology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom. AD - Cambridge Eye Unit, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, United Kingdom. AD - Moorfields Eye Hospital, London, United Kingdom. AD - UCL Institute of Ophthalmology, University College London, London, United Kingdom. FAU - Lu, Zhengqi AU - Lu Z AD - Department of Neurology, Psychological and Neurological Diseases Research Centre, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Lin, Haotian AU - Lin H AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. AD - Center of Precision Medicine, Sun Yat-sen University, Guangzhou, China. LA - eng GR - G0701386/MRC_/Medical Research Council/United Kingdom GR - G1002570/MRC_/Medical Research Council/United Kingdom PT - Journal Article DEP - 20201002 PL - Switzerland TA - Front Neurosci JT - Frontiers in neuroscience JID - 101478481 PMC - PMC7561709 OTO - NOTNLM OT - cerebrovascular disease OT - optical coherence tomography angiography OT - retinal microvasculature OT - retinal structure OT - retinal vascular density EDAT- 2020/11/03 06:00 MHDA- 2020/11/03 06:01 PMCR- 2020/01/01 CRDT- 2020/11/02 06:14 PHST- 2020/07/29 00:00 [received] PHST- 2020/09/11 00:00 [accepted] PHST- 2020/11/02 06:14 [entrez] PHST- 2020/11/03 06:00 [pubmed] PHST- 2020/11/03 06:01 [medline] PHST- 2020/01/01 00:00 [pmc-release] AID - 10.3389/fnins.2020.588515 [doi] PST - epublish SO - Front Neurosci. 2020 Oct 2;14:588515. doi: 10.3389/fnins.2020.588515. eCollection 2020.