PMID- 33132879
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201103
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 14
DP  - 2020
TI  - Neural Correlates of Stepping in Healthy Elderly: Parietal and Prefrontal Cortex 
      Activation Reflects Cognitive-Motor Interference Effects.
PG  - 566735
LID - 10.3389/fnhum.2020.566735 [doi]
LID - 566735
AB  - Gait analysis involving cognitive-motor dual task (DT) is a diagnostic tool in 
      geriatrics. Cognitive-motor interference effects during DT, such as decreased 
      walking speed and increased step-to-step variability, have a high predictive 
      value for fall risk and cognitive decline. Previously we showed the feasibility 
      of DT during functional magnetic resonance imaging (fMRI) using an MRI-compatible 
      stepping device. Here, we improved the DT-fMRI protocol with respect to task 
      difficulty and signal robustness, making it more suitable for individualized 
      analysis to better understand the neuronal substrates of cognitive-motor 
      interference effects. Thirty healthy elderly subjects performed cognitive and 
      motor single tasks (ST; stepping or finger tapping), as well as combined 
      cognitive-motor DT during fMRI. After whole brain group level analysis, a 
      region-of-interest (ROI) analysis and the computation of dual task costs (DTC = 
      activation difference ratio ST/DT) at individual level were performed. 
      Activations in the primary (M1) and secondary motor as well as in parietal and 
      prefrontal cortex were measured at the group level during DT. Motor areas showed 
      decreased activation whereas parietal and prefrontal areas showed increased 
      activation in DT vs. ST. Stepping yielded more distinctive activations in DT vs. 
      ST than finger tapping. At the individual level, the most robust activations 
      (based on occurrence probability and signal strength) were measured in the 
      stepping condition, in M1, supplementary motor area (SMA) and superior parietal 
      lobule/intraparietal sulcus (SPL/IPS). The distribution of individual DTC in 
      SPL/IPS during stepping suggested a separation of subjects in groups with high 
      vs. low DTC. This study proposes an improved cognitive-motor DT-fMRI protocol and 
      a standardized analysis routine of functional neuronal markers for 
      cognitive-motor interference at the individual level.
CI  - Copyright (c) 2020 Reinhardt, Rus-Oswald, Burki, Bridenbaugh, Krumm, Michels, 
      Stippich, Kressig and Blatow.
FAU - Reinhardt, Julia
AU  - Reinhardt J
AD  - Department of Neuroradiology, Clinical Neuroscience Center, University Hospital 
      Zurich, University of Zurich, Zurich, Switzerland.
AD  - Department of Radiology, Division of Diagnostic and Interventional 
      Neuroradiology, University Hospital of Basel, University of Basel, Basel, 
      Switzerland.
FAU - Rus-Oswald, Oana G
AU  - Rus-Oswald OG
AD  - Department of Neuroradiology, Clinical Neuroscience Center, University Hospital 
      Zurich, University of Zurich, Zurich, Switzerland.
AD  - University Department of Geriatric Medicine Felix Platter, Basel, Switzerland.
FAU - Burki, Celine N
AU  - Burki CN
AD  - Department of Radiology, Division of Diagnostic and Interventional 
      Neuroradiology, University Hospital of Basel, University of Basel, Basel, 
      Switzerland.
AD  - University Department of Geriatric Medicine Felix Platter, Basel, Switzerland.
FAU - Bridenbaugh, Stephanie A
AU  - Bridenbaugh SA
AD  - University Department of Geriatric Medicine Felix Platter, Basel, Switzerland.
FAU - Krumm, Sabine
AU  - Krumm S
AD  - University Department of Geriatric Medicine Felix Platter, Basel, Switzerland.
FAU - Michels, Lars
AU  - Michels L
AD  - Department of Neuroradiology, Clinical Neuroscience Center, University Hospital 
      Zurich, University of Zurich, Zurich, Switzerland.
FAU - Stippich, Christoph
AU  - Stippich C
AD  - Department of Neuroradiology, Clinical Neuroscience Center, University Hospital 
      Zurich, University of Zurich, Zurich, Switzerland.
FAU - Kressig, Reto W
AU  - Kressig RW
AD  - University Department of Geriatric Medicine Felix Platter, Basel, Switzerland.
FAU - Blatow, Maria
AU  - Blatow M
AD  - Department of Neuroradiology, Clinical Neuroscience Center, University Hospital 
      Zurich, University of Zurich, Zurich, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20200929
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC7550687
OTO - NOTNLM
OT  - cognitive-motor
OT  - dual task
OT  - elderly
OT  - gait
OT  - interference
EDAT- 2020/11/03 06:00
MHDA- 2020/11/03 06:01
PMCR- 2020/01/01
CRDT- 2020/11/02 06:14
PHST- 2020/06/02 00:00 [received]
PHST- 2020/08/19 00:00 [accepted]
PHST- 2020/11/02 06:14 [entrez]
PHST- 2020/11/03 06:00 [pubmed]
PHST- 2020/11/03 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2020.566735 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2020 Sep 29;14:566735. doi: 10.3389/fnhum.2020.566735. 
      eCollection 2020.