PMID- 33132899
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220418
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 12
DP  - 2020
TI  - Patterns of CSF Inflammatory Markers in Non-demented Older People: A Cluster 
      Analysis.
PG  - 577685
LID - 10.3389/fnagi.2020.577685 [doi]
LID - 577685
AB  - OBJECTIVE: In this study, we aimed to examine if patterns of CSF inflammatory 
      markers are correlated with global cognition, episodic memory, hippocampal 
      volume, and CSF AD-related pathologies among non-demented older people. METHODS: 
      We included 217 non-demented older individuals, including 87 subjects with normal 
      cognition (NC) and 130 subjects with mild cognitive impairment (MCI) from the 
      Alzheimer's Disease Neuroimaging Initiative (ADNI) study. Hierarchical cluster 
      analysis including nine inflammatory markers in CSF [Tumor necrosis 
      factor-alpha(TNF-alpha), TNF-R1, TNF-R2, transforming growth factor-beta1 (TGF-beta1), TGF-beta2, 
      TGF-beta3, Interleukin-21 (IL-21), IL-6, and IL-7] was conducted. RESULTS: We 
      identified two clusters among non-demented older people based on nine 
      inflammatory markers in CSF. Compared to the first cluster, the second cluster 
      showed significantly higher levels of CSF inflammatory markers (TNF-R1, TNF-R2, 
      TGF-beta1, TGF-beta3, and IL-6). Further, the second cluster was also associated with 
      higher levels of t-tau and p-tau levels in CSF. CONCLUSION: We observed a 
      subgroup of non-demented older people characterized by increased levels of 
      inflammatory markers in CSF. Further, this subgroup showed higher levels of t-tau 
      and p-tau levels in CSF.
CI  - Copyright (c) 2020 Peng, Chen, Chi, Zhou, Shi and The Alzheimer's Disease 
      Neuroimaging Initiative.
FAU - Peng, Yangdi
AU  - Peng Y
AD  - Department of Respiratory Medicine, Yongjia County Traditional Chinese Medicine 
      Hospital, Wenzhou, China.
FAU - Chen, Bin
AU  - Chen B
AD  - Department of Respiratory Medicine, Yongjia County Traditional Chinese Medicine 
      Hospital, Wenzhou, China.
FAU - Chi, Lifen
AU  - Chi L
AD  - Department of Neurology, Ruian People's Hospital, The Third Affiliated Hospital 
      of Wenzhou Medical University, Wenzhou, China.
FAU - Zhou, Qiang
AU  - Zhou Q
AD  - Department of Neurology, Ruian People's Hospital, The Third Affiliated Hospital 
      of Wenzhou Medical University, Wenzhou, China.
FAU - Shi, Zhenjing
AU  - Shi Z
AD  - Department of Intervention, Ruian People's Hospital, The Third Affiliated 
      Hospital of Wenzhou Medical University, Wenzhou, China.
CN  - Alzheimer's Disease Neuroimaging Initiative
LA  - eng
GR  - U01 AG024904/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20201006
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC7573280
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cluster analysis
OT  - cytokines
OT  - inflammation
OT  - tau
EDAT- 2020/11/03 06:00
MHDA- 2020/11/03 06:01
PMCR- 2020/01/01
CRDT- 2020/11/02 06:14
PHST- 2020/06/29 00:00 [received]
PHST- 2020/09/15 00:00 [accepted]
PHST- 2020/11/02 06:14 [entrez]
PHST- 2020/11/03 06:00 [pubmed]
PHST- 2020/11/03 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2020.577685 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2020 Oct 6;12:577685. doi: 10.3389/fnagi.2020.577685. 
      eCollection 2020.