PMID- 33133572
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2048-7177 (Print)
IS  - 2048-7177 (Electronic)
IS  - 2048-7177 (Linking)
VI  - 8
IP  - 10
DP  - 2020 Oct
TI  - Alleviative effect of Ruellia tuberosa L. on NAFLD and hepatic lipid accumulation 
      via modulating hepatic de novo lipogenesis in high-fat diet plus 
      streptozotocin-induced diabetic rats.
PG  - 5710-5716
LID - 10.1002/fsn3.1868 [doi]
AB  - Ruellia tuberosa L. (RTL) exhibits phytochemical activities and has been used as 
      a folk medicine for curing diabetes mellitus in East Asia for decades. This study 
      investigated the effect of RTL aqueous and ethanolic extracts on nonalcoholic 
      fatty liver disease (NAFLD) and hepatic lipid accumulation in high-fat diet (HFD) 
      and streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) rats. 
      Administration of RTL aqueous extract (RTLW) or ethanolic extract (RTLE) at 
      dosage of 100 or 400 mg/kg body weight for 4 weeks was carried out in 
      HFD/STZ-induced T2DM rats. Liver weight, adipose (epididymal and perirenal 
      adipose tissues) weight, hepatic triglyceride level, and de novo lipogenesis 
      (DNL)-associated protein expression were monitored after scarification. The 
      results revealed that RTLW and RTLE reduced relative liver weight and relative 
      fat weights in HFD/STZ-induced T2DM rats. RTLW and RTLE also ameliorated NAFLD 
      and hepatic triglyceride (TG) accumulation in diabetic rats. Moreover, hepatic 
      DNL-regulated enzymes such as sterol regulatory element-binding protein-1 
      (SREBP1) and fatty acid synthase (FAS) expression were significantly suppressed 
      by RTLE (100 and 400 mg/kg body weight) in diabetic rats. The evidences of this 
      study suggest that RTL possesses potential on alleviating NAFLD and lipid 
      accumulation via regulating DNL in the liver of HFD/STZ-induced T2DM rats.
CI  - (c) 2020 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
FAU - Huang, Da-Wei
AU  - Huang DW
AD  - Department of Biotechnology and Food Technology Southern Taiwan University of 
      Science and Technology Tainan City Taiwan.
FAU - Lo, Yangming Martin
AU  - Lo YM
AD  - Institute for Advanced Study Shenzhen University Shenzhen China.
FAU - Chang, Wen-Chang
AU  - Chang WC
AD  - Department of Food Science National Chiayi University Chiayi City Taiwan.
FAU - Lin, Chia-Yu
AU  - Lin CY
AD  - Graduate Program of Nutrition Science National Taiwan Normal University Taipei 
      Taiwan.
FAU - Chen, Jou-An
AU  - Chen JA
AD  - Graduate Program of Nutrition Science National Taiwan Normal University Taipei 
      Taiwan.
FAU - Wu, James Swi-Bea
AU  - Wu JS
AD  - Graduate Institute of Food Science and Technology National Taiwan University 
      Taipei Taiwan.
FAU - Huang, Wen-Chung
AU  - Huang WC
AD  - Graduate Institute of Health Industry Technology Chang Gung University of Science 
      and Technology Taoyuan Taiwan.
FAU - Shen, Szu-Chuan
AU  - Shen SC
AUID- ORCID: 0000-0001-9005-0455
AD  - Graduate Program of Nutrition Science National Taiwan Normal University Taipei 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20200909
PL  - United States
TA  - Food Sci Nutr
JT  - Food science & nutrition
JID - 101605473
PMC - PMC7590278
OTO - NOTNLM
OT  - Ruelliatuberosa L.
OT  - de novo lipogenesis
OT  - hepatic lipid accumulation
OT  - type 2 diabetes mellitus
COIS- The authors declare that they do not have any conflict of interest.
EDAT- 2020/11/03 06:00
MHDA- 2020/11/03 06:01
PMCR- 2020/09/09
CRDT- 2020/11/02 06:17
PHST- 2020/07/13 00:00 [received]
PHST- 2020/08/12 00:00 [revised]
PHST- 2020/08/15 00:00 [accepted]
PHST- 2020/11/02 06:17 [entrez]
PHST- 2020/11/03 06:00 [pubmed]
PHST- 2020/11/03 06:01 [medline]
PHST- 2020/09/09 00:00 [pmc-release]
AID - FSN31868 [pii]
AID - 10.1002/fsn3.1868 [doi]
PST - epublish
SO  - Food Sci Nutr. 2020 Sep 9;8(10):5710-5716. doi: 10.1002/fsn3.1868. eCollection 
      2020 Oct.