PMID- 33133689
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2090-1232 (Print)
IS  - 2090-1224 (Electronic)
IS  - 2090-1224 (Linking)
VI  - 26
DP  - 2020 Nov
TI  - Polymeric-based microneedle arrays as potential platforms in the development of 
      drugs delivery systems.
PG  - 137-147
LID - 10.1016/j.jare.2020.07.017 [doi]
AB  - BACKGROUND: Microscopic patches as quite promising platforms in transdermal drug 
      delivery suffer from conventional injections. In other hand, a wide range of 
      pharmacokinetics, ranging from fast oral administration to sustained drug 
      delivery, can be implemented with the help of microneedle arrays (MNAs). AIM OF 
      REVIEW: Hence, in this paper, we overviewed different kinds of MNAs such as 
      solid/coated, hollow, porous, hydrogel/swellable, and merged-tip geometry 
      followed by introducing different types of material (silicon, glass, ceramics, 
      dissolving and biodegradable polymers, and hydrogel) used for fabrication of 
      MNAs. Afterwards, some conventional and brand-new simple and customizable MN mold 
      fabrication techniques were surveyed. Polymeric MNAs have received a great deal 
      of attention due to their potential biocompatibility and biodegradability in 
      comparison to other materials. Therefore, we also covered different kinds of 
      polymers such as hydrogel/swellable, dissolving and biodegradable analogues used 
      for the development of MNAs as potential candidates in drug delivery systems 
      (DDSs). Finally, we discussed different challenges and future perspectives in the 
      aspect of MNAs-based drug delivery platforms. KEY SCIENTIFIC CONCEPTS OF REVIEW: 
      This review may provide guidelines for the rational design of polymeric 
      MNAs-based DDSs for promising programmable drug release and enhanced therapeutic 
      effect.
CI  - (c) 2020 The Authors. Published by Elsevier B.V. on behalf of Cairo University.
FAU - Meng, Fansu
AU  - Meng F
AD  - Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou 
      University of TCM, Zhongshan, Guangdong 528400, China.
FAU - Hasan, Anwarul
AU  - Hasan A
AD  - Biomedical Research Center, Qatar University, Doha 2713, Qatar.
AD  - Department of Mechanical and Industrial Engineering, College of Engineering, 
      Qatar University, Doha 2713, Qatar.
FAU - Mahdi Nejadi Babadaei, Mohammad
AU  - Mahdi Nejadi Babadaei M
AD  - Department of Molecular Genetics, Faculty of Biological Science, North Tehran 
      Branch, Islamic Azad University, Tehran, Iran.
FAU - Hashemi Kani, Pegah
AU  - Hashemi Kani P
AD  - Department of Biotechnology, Faculty of Basic Science, East Tehran Branch, 
      Islamic Azad University, Tehran, Iran.
FAU - Jouya Talaei, Amir
AU  - Jouya Talaei A
AD  - Department of Biotechnology, Faculty of Basic Science, East Tehran Branch, 
      Islamic Azad University, Tehran, Iran.
FAU - Sharifi, Majid
AU  - Sharifi M
AD  - Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran 
      Medical Sciences, Islamic Azad University, Tehran, Iran.
FAU - Cai, Tiange
AU  - Cai T
AD  - College of Life Sciences, Liaoning University, Shenyang, Liaoning 110036, China.
FAU - Falahati, Mojtaba
AU  - Falahati M
AD  - Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran 
      Medical Sciences, Islamic Azad University, Tehran, Iran.
FAU - Cai, Yu
AU  - Cai Y
AD  - College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
AD  - Cancer Institute of Jinan University, Guangzhou, Guangdong 510632, China.
AD  - International Cooperative Laboratory of Traditional Chinese Medicine 
      Modernization and Innovative Drug Development of Chinese Ministry of Education 
      (MOE), School of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200801
PL  - Egypt
TA  - J Adv Res
JT  - Journal of advanced research
JID - 101546952
PMC - PMC7584683
OTO - NOTNLM
OT  - Biodegradable polymers
OT  - Dissolving polymers
OT  - Drug delivery
OT  - Fabrication method
OT  - Hydrogel polymers
OT  - Microneedle array
EDAT- 2020/11/03 06:00
MHDA- 2020/11/03 06:01
PMCR- 2020/08/01
CRDT- 2020/11/02 06:18
PHST- 2020/04/17 00:00 [received]
PHST- 2020/07/23 00:00 [revised]
PHST- 2020/07/29 00:00 [accepted]
PHST- 2020/11/02 06:18 [entrez]
PHST- 2020/11/03 06:00 [pubmed]
PHST- 2020/11/03 06:01 [medline]
PHST- 2020/08/01 00:00 [pmc-release]
AID - S2090-1232(20)30176-4 [pii]
AID - 10.1016/j.jare.2020.07.017 [doi]
PST - epublish
SO  - J Adv Res. 2020 Aug 1;26:137-147. doi: 10.1016/j.jare.2020.07.017. eCollection 
      2020 Nov.